Ask HN: Wrist Pain

I've been a heavy computer user for more than a decade and I think all those hours are finally taking a toll on my wrists. About a year ago the discomfort was so intense that I switched hands so that now I use my left hand both at work and at home. The problem is that my day job has me at a computer for 35-40 hours/week and then I come home and program for another 20-25.

Currently there's kind of a dull, persistent numbness 24/7. Also, when I bend my wrists too far forward or backwards, I feel a sharp pain on the back of my hands. I also occasionally wake up at night and notice that they're numb, which I've read is a symptom of carpal tunnel.

I've tried a few ergonomic changes including a new chair, adjusting the monitor position, and a wrist pad for my keyboard and mouse, and even a wrist brace a portion of the time, but the discomfort persists. I asked my doctor about it a few months ago and he gave me a 20 page packet with the usual diagrams showing where my head should be positioned in relation to my monitor and things like that, but not much of it was practical "do this" advice.

I'd like to work on a startup in a few years and this is a major concern.

I figure a lot of you have had similar problems. What worked for you?