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carbocation

14,942 karma

Cardiology & human genetics.

Previously founded MyChances.net (acquired by Parchment in 2011).

Email: james@{my HN username}.com

https://carbocation.com

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Posts153
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www.interconnects.ai 1mo ago

Claude Fable 5 and new AI safety fables

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cw3e.ucsd.edu 2mo ago

New AQPI C-Band Radar Delivers Impressive Results

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arxiv.org 9mo ago

A nearly pristine star from the Large Magellanic Cloud

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www.cnbc.com 1y ago

Waymo says it reached 10M robotaxi trips, doubling in five months

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www.nejm.org 1y ago

Patient-Specific in Vivo Gene Editing to Treat a Rare Genetic Disease

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www.nytimes.com 1y ago

Are You Smarter Than A.I.? (NYT article on Chollet's logic puzzles)

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www.science.org 1y ago

NIH hit with freezes on meetings, travel, communications, and hiring

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www.bmj.com 1y ago

Age against the machine: susceptibility of LLMs to cognitive impairment

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www.ox.ac.uk 2y ago

First proof that "plunging regions" exist around black holes in space

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speechresearch.github.io 2y ago

NaturalSpeech 3: Zero-Shot Speech Synthesis with Factorized Codec and Diffusion

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www.science.org 2y ago

A principal odor map unifies diverse tasks in olfactory perception

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github.com 2y ago

Stable-Diffusion.cpp

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workspaceupdates.googleblog.com 3y ago

Simplify and strengthen sign-in by enabling passkeys for your users

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www.nytimes.com 3y ago

Advanced Data Protection: Why You Should Enable Apple’s New Security Feature

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pals.ttic.edu 3y ago

Lifting Pretrained 2D Diffusion Models for 3D Generation

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www.theregister.com 3y ago

Google challenges US ISPs with 100Gbps fiber broadband

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www.canarymedia.com 4y ago

Doe backs US battery materials production with $107M loan

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www.nature.com 4y ago

Self-heating plasmas offer hope for energy from fusion

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arxiv.org 4y ago

A ConvNet for the 2020s

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ataylor.io 4y ago

Building a Neural Network in Go

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www.cnbc.com 4y ago

Google’s pivot away from bank accounts

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cloud.google.com 4y ago

Apricot: a new subsea cable connecting Singapore to Japan

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www.cnbc.com 5y ago

Producer prices climb 6.6% in May, largest 12-month increase on record

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www.nih.gov 5y ago

AstraZeneca may have included outdated information from trial

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arxiv.org 5y ago

High-Performance Large-Scale Image Recognition Without Normalization

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www.nature.com 6y ago

Continuous prediction of future acute kidney injury

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www.nature.com 7y ago

Prototype of clinical trials in an untrustworthy environment using blockchain

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www.nature.com 7y ago

Prototype of clinical trials in an untrustworthy environment using blockchain

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jamanetwork.com 7y ago

E-Cigarette Use Associates with Subsequent Initiation of Tobacco Cigarettes

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www.usatoday.com 7y ago

Hackers send thousands of DNA test kits to random strangers

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Was the choice of such a small model driven by a desire for high tok/sec? I ask because an m4 pro 48gb machine can run larger models (if model intelligence is the thing that would make it more useful).

Claude Opus 4.7 3 months ago

Is there a page where I could read more? What's unintuitive at a glance is that Opus 4.7 has a lower success rate than Sonnet 4.6 (90% vs 100%) while having a higher Avg Percentile (87.2% vs 70.9%).

The $20 Plus plan still exists, and does not give access to the pro model.

The $200 Pro plan still exists, and does give access to the pro model.

What is new is a $100 Pro plan that does give access to the pro model, with lower usage limits than the $200 Pro plan.

The article kind of downplays the most interesting elements. Not an expert, but to my limited understanding:

* I think this is the longest-range use of a ballistic missile in anger, possibly ever?

* This seems to reveal previously-unknown range of Iranian ballistic missiles and, if true, could touch basically all of Europe?

Waymo Safety Impact 4 months ago

I think the average is ballpark 1 per 100 million miles, so my guess is that someday they might show this, but they probably want to wait til they have more miles driven.

Gemini 3.1 Pro 5 months ago

I agree with this; it feels like the most likely tool to drop its high-level comments in code comments.

This model was able to transcribe Bad Bunny lyrics over the sound of the background music, played casually from my speakers. Impressive, to me.

To add more information, the intervention was guidance about caffeine intake. From the Methods:

If allocated to caffeinated coffee consumption, patients were encouraged to drink at least 1 cup of caffeinated coffee (or at least 1 espresso shot) and other caffeine-containing products every day as per their usual lifestyle. It was recommended that patients in the coffee consumption group not intentionally increase or decrease consumption of coffee or other caffeine-containing products.

If allocated to the abstinence group, patients were encouraged to completely abstain from coffee, including decaffeinated coffee, and other caffeine containing products.

The claim on an individual level is not objectionable to me. The question is that if we extrapolate it out to the population and actually take this action for everyone, do we make people better off? This is what clinical trials (or at least large observational studies) try to achieve. Right now, it is not clear.

    Key Takeaway: Get a CT or CTA scan, and if you can afford it go for the CTA with Cleerly.
There is a reason that we don't recommend getting imaging for everyone, and that reason is uncertainty about the benefit vs the risks (cost, incidentalomas, radiation, etc, all generally minor). Most guidance recommends calcium scoring for people with intermediate risk who prefer to avoid taking statins. This is not a normative statement that is meant to last the test of time: it may well be the case that these tests are valuable for a broader population, but the data haven't really caught up to this viewpoint yet.

One thing that wasn't mentioned is the max sustained screen brightness for SDR, which is higher on the M4 Pro (1000 nits) compared to the M4 Air or M1 Pro (500 nits).