Scientists say they've reversed brain aging in mice with a nasal spray

https://www.sciencedaily.com/releases/2026/05/260526022018.htm

by bookmtn • 2 months ago

68 28 2 months ago

Was looking for the “in mice” in this article and found none… anybody got a link to the paper please

kurthr2• 2 months ago

2.2 Animals and Study Design The study comprised two cohorts of C57BL/6 mice: young adult (3 months old) and late middle-aged (18 months old). We chose 18 months old mice, as this mouse age is approximately equivalent to a 60-year-old human (Dutta and Sengupta 2016).

I posted paper above, DOI was linked at the end.

ddeck• 2 months ago

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

kurthr2• 2 months ago

The source paper:

https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

8bitsrule• 2 months ago

Addition of a source-paper link to complex science studies like this should be encouraged (if not mandatory) at the top of posts like this.

Real-world reports can be valuable to some readers who are non-plussed by journalistic interpretations.I don't see deception going on in this one; it's clear about its limits.

trodney• 2 months ago

Excellent news if you're a mouse.

instagib• 2 months ago

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.”

(In mice)

Topgamer7• 2 months ago

Pinky and the brain can now sleep soundly as they age like wine

ianburrell• 2 months ago

We are going to end up with immortal mice.

cookiengineer• 2 months ago

Always pack your towel for space travel!

Enginerrrd• 2 months ago

Actually the fact that we don’t have immortal mice is what makes me feel like this current optimism with respect to life extension is pretty unrealistic.

CoastalCoder• 2 months ago

Algernon for Flowers.

delichon• 2 months ago

I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon?

We have several drugs that emulate dementia in various ways and call them recreational.

MattDamonSpace• 2 months ago

Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation

jmward01• 2 months ago

I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the system that evolves from it is actively worse than nearly any other system with a good loss function like 'health' or even just 'fame and notoriety for the scientists involved'

gpjt2• 2 months ago

Hmmm. "Comforting haze" seems dubious. My grandmother had Alzheimer's and at least from the outside it seemed like a bad LSD trip that never ended. She didn't understand what was happening and was scared.

Sample size of one and anecdotal of course, but...

qnleigh• 2 months ago

Behavioral testing showed that treated models performed significantly better on memory and recognition tasks.

"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:

Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.

Cool! But please be honest in your press releases.

ryankrage77• 2 months ago

ctrl+f'd for 'mice', no results. I can think of no other word than deceit.

cameldrv• 2 months ago

It’s very probably not deceit, it’s just biomedical research jargon from the original paper that was written for a scientist audience that didn’t get translated to a lay audience language for a sciencedaily/press release format.

dang• 2 months ago

Ok, I've inmiced the title above. Thanks for catching this.

gpjt2• 2 months ago

Love the verbification!

Morromist• 2 months ago

Imagine the political implications of this if it actually worked.

dolphinscorpion• 2 months ago

These billionaire mice are funding this research; humans should do the same

hunterpayne• 2 months ago

So you are telling me that the mice from Hitchhikers guide are real?

“These creatures you call mice you see are not quite as they appear, they are merely the protrusions into our dimension of vast, hyper-intelligent pan-dimensional beings.”

—Slartibartfast

molticrystal• 2 months ago

edit: admin dang has fixed the title

I always interpret the rule [0] "Otherwise please use the original title, unless it is misleading or linkbait; don't editorialize." as applying to stories like this one.

Adding the words [in mice] would not only be the acceptable exception the rule is referring to, but probably necessary. This would align the title properly with the article contents and avoid giving people false expectations about human results.

[0] https://news.ycombinator.com/newsguidelines.html

Zealotux• 2 months ago

This headline is keeping me young because I keep reading it every five years or so.

Scientists say they've reversed brain aging in mice with a nasal spray

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