Vitamin C Boosts Epidermal Growth via DNA Demethylation

https://www.jidonline.org/article/S0022-202X(25)00416-6/fulltext

by gnabgib • 1 year ago

137 82 1 year ago

deadbabe2• 1 year ago

This is why you need to include a good vitamin C serum in your daily skincare routine.

m463• 1 year ago

"I always use an after-shave lotion with little or no alcohol because alcohol dries your face out and makes you look older. Then moisturizer, then an anti-aging eye balm, followed by a final moisturizing "protective" lotion..."

Bateman stares into the mirror. The masque has dried, giving his face a strange distorted look as if it has been wrapped in plastic. He begins slowly peeling the gel masque off his face.

ipnon• 1 year ago

“Looking good doesn’t affect your success” is one of those pernicious anti-advices like “elite university degrees don’t matter” and “family connections are worthless in our meritocratic society.”

oneshtein• 1 year ago

Which daily skincare you recommend to use?

deadbabe2• 1 year ago

Vanicream Vitamin C serum is 5% THD, oil soluble and gentle on skin!

mmmpetrichor• 1 year ago

I get all my skincare advice from hackernews.

JumpCrisscross• 1 year ago

A, B, C, D, E and water.

A is a light retinol. B is niacinamide. C is C. D you should be making from sunlight (or getting from supplements). E is E. Water is moisturiser.

Pretty much all evidence-based skincare comes down to providing these vitamins (plus water) to your skin.

WhereIsTheTruth• 1 year ago

or invest in a steam cooker and stop eating junk food?

woleium• 1 year ago

So possible treatment for age related thinning of the skin.

kanbankaren2• 1 year ago

Well, there are already multiple skin creams with Vitamin C. They have been available for a long time, but they are expensive for what it provides.

Just taking a 500mg x 2 Vitamin C supplements should provide enough for skin repair.

inkyoto8• 1 year ago

Let's not engage in quakery and resort to knowledge instead.

Oral and transdermal (topical) application of Vitamin C (and other molecules in general) follow completely different routes with different absorption rates and accompanying nuances.

Oral intake. Absorption rate is dosage dependent:

  – At moderate doses (≤ 250 mg/day): 70–90 per cent of ascorbate is absorbed into the bloodstream. Bloodstream means just that – Vitamin C will be distributed throughout the entire body, which includes tissues, internal organs and skin. Active absorption takes place in the small intestine predominantly by SVCT1 and SVCT2 sodium-ascorbate co-transporters.

  – At high doses (≥ 1g a day): passive diffusion takes over and also takes place in the small intestine although now via GLUT transporters that become saturated and absorption efficiency drops to 50 per cent or lower.

The half-life of Vitamin C taken orally is approximately four hours anyway, after which any excess of it still circulating will be rapidly excreted via the renal route (kidneys). Studies report that significantly less than 0.1 per cent makes into the epidermal (skin) layer.

Transdermal (topical) application. Depends on the concentration and several factors, but a 20% concentration serum (not a cream) can achieve a > 80% absorption rate through the skin into receptor fluid after 24 hours. Half-life of Vitamin C applied topically is approximately 4 days.

Recap: less than < 0.1 % / 4 hours half-life for the oral route vs more than 80 % / 4 days half-life for the transdermal route.

MangoToupe3• 1 year ago

Therapy is another option

ch4s3• 1 year ago

Red light, or something more chemical?

anon373839• 1 year ago

I know this was a joke, but I can't really understand the worldview that says people should accept physical decline in a passive way. The fact is, we actually have a lot of control over how quickly and how well we age. Just using sunscreen can prevent a lot of the age-related loss of skin structure. And interventions like topical retinoids or collagen induction (e.g. microneedling) can even restore some thickness and elasticity that have already been lost. This also goes for fitness, joint health, and a lot of other things. Caring for your body is actually well aligned with the goals of psychotherapy.

burnt-resistor2• 1 year ago

Oh lord, not another "wellness hack". And here comes the people giving themselves kidney stones and spinal cord problems to be featured on Chubbyemu.

https://youtu.be/oeyt2zVqCG8

cultofmetatron• 1 year ago

honestly that video was surprising on how safe zinc is. I mean he went so beyond anything close to a reasonable dose. bro was eating tubes of dental paste.

asveikau2• 1 year ago

This is a weird video to see after one of my son's doctors told me I should supplement him with zinc. Of course I'm following dosage recommendations.

ggm• 1 year ago

In cell cultures. So nothing about topical, or digestive pathways. Just, expose cells to vitamin c rich medium.

How would topical application work, and what kind of homeostasis effect, from ingestion.

If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.

ethan_smith• 1 year ago

Topical vitamin C (L-ascorbic acid) at concentrations of 10-20% with pH <3.5 can penetrate the stratum corneum, though stability and formulation significantly impact bioavailability.

jijijijij4• 1 year ago

You can just freshly mix cheap vitamin C powder and water to the desired concentration, adjust pH to be less irritating. The solution can last for a few days, if cooled and protected from light. For it to be effective (according to studies), it needs to be applied daily/frequently. However, DIY is so cheap, you can use it all over your body. Wash/wipe off excess (see below).

The problem is commercialization. Vitamin C is very, very reactive, so formulating it for shelf storage and production is challenging. I think you either have to add expensive/exotic antioxidant systems, or rely on ascorbate derivatives which may be less/not effective.

Fair warning: Vitamin C degrades to dehydroascorbic acid: After some delay, vitamin C solution may stain skin and everything in contact yellow. DHA may also further break down into erythrulose, a self-tanning agent browning the skin semi-permanently (likely not very healthy). Vitamin C may also react with other things (eg. skin care products) in unpredictable ways and can actually form radicals under some conditions. Eg. It can react with benzoic acid to form benzene. On the modern skin, with UV exposure, a primordial soup of "actives", complex hydrocarbons and all natural metal catalysts, vitamin C may facilitate genesis…

The science is promising, but the chemistry of vitamin C is hard to control, or even reason about.

majkinetor13• 1 year ago

Everybody is low on C in diet. It's thermolabile, and there is glucose competition for GLUT transporters.

IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.

nabla94• 1 year ago

This is not true. 2g is the max recommended dose.

Most people can get enough vitamin C each day from food or drink. 3/4 cup of orange juice daily is enough. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...

Taking vitamin C orally decreases muscle mitochondrial biogenesis and harms the health benefits of training, like increased insulin resistance. (well established from multiple studies, easy to google).

There was huge antioxidant craze in late 90's and 00's when taking antioxidant supplements like C was considered the right thing to do. Now we know that just taking more antioxidants does not directly help with oxidization tress, because it messes up metabolism and can even increase it.

jb19917• 1 year ago

Please do not spread misinformation here. It can be misleading at best, dangerous at worst.

jb19917• 1 year ago

IMO, everybody should take at least 2g daily in a couple of doses

I strongly caution against this kind of blanket recommendation. For most people, taking such a high dose without medical guidance is unwise. Unless a healthcare professional has specifically advised it, this level of supplementation goes well beyond established guidelines.

There is substantial research highlighting potential risks, including kidney damage, associated with high-dose vitamin C intake (as referenced elsewhere in this thread).

Anyone considering this should thoroughly research the risks and consult a qualified medical professional before proceeding.

cookiengineer• 1 year ago

Maybe plasters with ascorbin acid in it? That would be the first thing that comes to mind. Or maybe plaster spray where it's mixed with the typical protein foam?

SlowTao• 1 year ago

As a vaguely related aside, my skin is typically better when I have a decent vitamin c intake. Essentially all I do is have a orange or two every night. Nothing too extreme.

This is VERY anecdotal!

jandrewrogers• 1 year ago

Oranges are not particularly high in ascorbic acid as such things go, so I would expect any effect to be pretty marginal. Other fruits and vegetables contain considerably more.

amelius• 1 year ago

The effects can be significant, even if not due to vit C but something else in the oranges.

jijijijij4• 1 year ago

They are, but you have to eat the peel, too. I actually love it, but it’s not to everyone’s taste. Of course the oranges need to be free of pesticides, peel declared suitable for consumption.

radu_floricica• 1 year ago

This just found a potential mechanism, right? Because we did know that, AFAIK. A doctor recommended me vitamin C for faster healing of minor lesions about a decade ago.

apt-apt-apt-apt• 1 year ago

So true. I have been vitamin-C deficient the past 20 years and my skin has definitely degraded.

BugsJustFindMe• 1 year ago

the past 20 years

That's called aging.

sydbarrett74• 1 year ago

With conflicting evidence that vitamin C may promote tumour growth, how much study has been done as to whether this might exacerbate skin cancer?

inkyoto8• 1 year ago

… coffee is good for you, coffee is bad for you. Table salt is bad for you, table salt is good for you. Red wine is good for you, red wine is bad for you. We have gone a full circle on each of those so many times.

Linus Pauling used IV injections of vitamin C in 1970's to treat terminal cancer tumours, subsequent studies in 1990's failed to reproduce the effect so it was abandoned (and discredited), and over the past decade the interest has rekindled the research and phase 3 trial is underway for high dose IV injections of vitamin C as adjuvant therapy for pancreatic and solid cancer tumours[0].

[0] https://link.springer.com/article/10.1007/s12094-024-03553-x

epcoa• 1 year ago

Pauling spins furiously in his grave in approval.

brador• 1 year ago

Could be why so many suggested home skin remedy moisturisers contain lemon juice.

farseer• 1 year ago

Vitamin C supplements and cancer risk is an active area of research. Unless there is a genuine deficiency, I would stay away from supplements just to look pretty until there is more clarity.

richarlidad• 1 year ago

Vitamin C’s relationship with cancer risk appears complex and context-dependent. While maintaining adequate blood levels (≥60.19 μmol/L) is associated with reduced cancer mortality, supplementation may increase postmenopausal breast cancer risk by 32% in women with already high dietary intake. This suggests a U-shaped relationship where both deficiency and excess may be detrimental, emphasizing the importance of personalized approaches to vitamin C intake.

See: https://inspectsupplement.com/vitamin-c/#Cancer

metalman• 1 year ago

Vitamin C/ascorbic acid/swimming pool cleener is interesting stuff, but it is not generaly benificient as a suppliment for healthy people. I will(very) occasionaly chew up a gram, or throw a spoon full into a summer drink concoction, but I also know someone who got a tounge blister from copying me chewing up a vitC pill, someone I knew well, who had such different respinses to things that we started to experiment lightly,they also had a variant form of collegen in all of there conective tissue, which made them vastly more flexible than most people......which(oddly)relates to the titles subject matter

Vitamin C Boosts Epidermal Growth via DNA Demethylation

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