mcbain

You might enjoy the matrix of regional sizes and names on Wikipedia: https://en.wikipedia.org/wiki/Beer_in_Australia#Beer_glasses

No, us locals don't know them all either!

https://www.avherald.com/h?article=536bb98e

Captain and first officer are reported to have died in the accident, two fire fighters on board of the truck received serious injuries, 13 passengers received injuries.

The former. It doesn't quite roll off the tongue, but with my (Australian) accent the difference is minor.

Yes, with MRI brain too. I was on 4/year, but that number is reducing as time goes on without recurrence.

I have multiple scans a year. "Scanxiety" is real.

Spot on. And dealing with false positives sucks.

One caveat is that regular PET isn't so good in the brain - there is so much metabolic activity that everything glows. So I get an MRI Brain to go with my regular full body PET/CT (cancer 5 years ago with recurrence 18 months later, currently NED).

Previously: https://news.ycombinator.com/item?id=45514378

Linde was definitely around as a distinct brand in Australia before they bought BOC in 2006, but since then as you said, they now just trade as BOC.

When have they ever claimed that?

As others pointed out, these are stage I trials and these are patients that have had other treatments already. In particular the melanoma patients had already had other immunotherapy - which is known to work for 50+% of cases - so this could help plugging the gap for the rest.

The testing here is not just that it is safe on skin, but the SPF test itself is done by slathering it on humans and exposing them to light to determine a rating.

Also the club scenes, with a bunch of regulars from Hellfire/Black Market, on Regent St. (Now a cafe supply store.)

Sadly Richard has now had recurrence. There is still hope for this treatment for others, and it likely extended his life, but it isn't happily ever after this time.

https://www.nature.com/articles/s41591-025-03512-1

Ipi/nivo/relatlimab and then a peptide vaccine that they haven't written up yet.

No chemo. The entire idea of this regime is to hit the tumour with immuno to get the reaction. They want lots of tumour cells and for it to be "treatment naive" - Richard hadn't even had corticosteroids, which dampens immune.

Once they primed his system they excised as much as possible and kept the immuno going while doing a course of radiation.

Profs Long and Scolyer work with melanoma where chemo is rarely used these days.

https://youtu.be/Y5K9HBiJpuk

I think Petter's (Mentour Pilot) delve into it is quite good - there's a lot of detail I hadn't known.

It's easy for (say) AWS to terminate your EC2 instances. Do they also delete your DB backups? Delete your S3 buckets?

All of these incur costs. How hard a cap do you want?

One big trial still going: https://clinicaltrials.gov/study/NCT03739931

There's a bunch of different immuno types for melanoma (and other cancers). That one is a combo of nivolumab (aka Opdivo) and relatlimab.

Nivo is used a lot for melanoma, also commonly in combo with ipi (ipilimumab, yervoy). Pembro (keytruda) is the other common one.

Anyway, any of these can have adverse effects so patients are closely monitored.

For me, my thyroid didn't like nivo much but recovered. But we stopped after a couple of cycles of ipi+nivo because I was starting to develop colitis. And more importantly it wasn't slowing development of my melanomas.

It does launch an instance and take a snapshot but what's happening is the sysprep and OOBE stuff that can take 10 mins or so (you can find it in the console and startup logs). That's a lot more overheard than just hydrating an EBS volume.

https://docs.aws.amazon.com/AWSEC2/latest/WindowsGuide/win-a...

This is seeing great results but unless I'm mistaken, this started stage III in July 2023: https://classic.clinicaltrials.gov/ct2/show/NCT05933577

They are https://en.m.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors

The hint is the -mab naming.

I get an MRI Brain every three months. I usually opt out of the piped music - mostly because it's either a bad choice by the radiology techs or tuned to a generically awful radio station - but the headphones lock into the head cradle so I use them with earplugs underneath. I close my eyes and tune out and try to not sleep (and twitch so they have to restart the capture).

Some of the pulse sequences are rhythmic and I find the entire thing somewhat meditative, but there are many other places I'd rather be.

The title here currently drops "Western" from the linked article and the start of the airport name - importantly this is the yet to be completed WSI not the existing SYD.

That wasn't my experience

Then stop talking like you understand cancer treatment or clinical trials, because it is exactly how it works for thousands of people every year.

Too bad

Pardon me? "Too bad" that I had recurrence of cancer and that immunotherapy was starting to cause colitis? Immunotherapy which turned out was never going to work because of the genetics of my cancer, the sequencing of which was completed thanks to one of the multiple clinical trials I'm on.

I'm sorry about your mother, but spreading your ignorance does not help other people.

No, immuno isn't always a second line treatment.

No you don't need to have failed other treatments before being added to a clinical trial. Quite the opposite in many cases - they have entry criteria so that they can be sure any effects (good or bad) can be linked to the trial and not from something else.

No if you got colitis from immuno, chemo won't "reset" it, but strong doses of steroids might. (We discontinued my immuno before I got to that point.)

There is no "most effective" treatment because cancer isn't one thing.

Chemo is effective for a few cancers but not for others. Immuno might be the most effective for those. Or chemo followed by immuno. Maybe it is CRT (chemoradio).

Or maybe there is no systemic treatment and all we can use is surgery and then maybe RT.

If it doesn't come out beforehand it'll likely be presented at ASCO: https://x.com/profglongmia/status/1753650640847597930

I'm not sure if they've said publicly what immunotherapy they used. I have seen it referred to as a combo, so I would guess ipi/nivo - that is Nivolumab (Opdivo) + Ipilimumab (Yervoy). They've been trialling those as neoadjuvant for melanoma: https://melanoma.org.au/paper/neo-adjuvant-immunotherapy-eme...

Nivo is generally well tolerated, ipi less so. I only got to my 2nd cycle of ipi/nivo before we discontinued it. (I'd already had more cycles of nivo on a trial.) It can have neurological effects and encephalitis in rare cases, so maybe that's what they are referring to. I wouldn't say "poison" though.

As it happens, Prof Long is my medonc. We don't sit around chatting about Richard though, she's a bit busy on clinic days!

I don't always love the video format but Mentour talked about Spirit, Boeing, and the 737 MAX a few months ago: https://youtu.be/SmJgweFmoxs

The discussion about snowman hole issues and other problems is really alarming.