Covid-19 Intranasal Vaccine

https://news.griffith.edu.au/2024/08/27/game-changing-needle-free-covid-19-intranasal-vaccine/

by stubish • 2 years ago

196 123 2 years ago

news.griffith.edu.au

Very cool! Are there other vaccines that have been formulated for mucosal ingestion? What makes that delivery method so effective?

ZoomerCretin• 2 years ago

There's a nasal flu vaccine as well. Theoretically, it's supposed to induce immunity in mucous membranes and prevent infections in the first place, rather than merely reducing symptom severity. As for how effective it actually is at those goals, we'll have to see.

pixiemaster• 2 years ago

nasal flu is heavily used in scotlands schools, wheee flu vaccination is mandatory.

roenxi• 2 years ago

What makes that delivery method so effective?

This seems like an easy one to guess - your immune system has been developed over a very long time, is highly complex and has layers of defences everywhere that are all a little different. Training it to look for coronavirus in your muscles is less effective against coronaviruses than training it to look for infections in nasal mucus where said virus is actually trying to enter and exit the body.

bbzealot• 2 years ago

There were other similar (ie. nasal) vaccine candidates for COVID, like the Cuban MAMBISA [0], though it seems it never got final approval

duskwuff• 2 years ago

Some canine vaccines against respiratory infections are given as a nasal spray, e.g.

https://www.merck-animal-health-usa.com/nobivac/nobivac-intr...

Amezarak• 2 years ago

Your immune system has different "compartments." The mucosal immune compartment produces its own antibodies and its own immune response. The "jab" did not immunize the mucosal immune compartment, so people could and did catch and spread Covid - but they were protected from developing a serious infection because the virus was unable to spread in their body further. As it invades through your respiratory system, vaccinating the mucosal immune compartment means its stopped at the point of entry and does not spread to others or develop into even a mild case.

matznerd• 2 years ago

Pretty impressive, if true that it can stop infection, and potentially then transmission. Nasal vaccines have the ability to do this because of the potental for neutralizing activity along the nasal muscosa.

They make the claim so we'll have to see. I currently use a nitric oxide nasal spray as the nose is the major area to protect (and also use probiotic lozenges of the k12 strain for the throat).

--- “The vaccine offers potent protection against transmission, prevents reinfection and the spread of the virus, while also reducing the generation of new variants,” Dr Liu said.

“Unlike the mRNA vaccine which targets only the spike protein, CDO-7N-1 induces immunity to all major SARS-CoV-2 proteins and is highly effective against all major variants to date.

“Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.” ---

aaron695• 2 years ago

neutralizing activity along the nasal muscosa.

Low humidity drying the nose out seems to be why planes and winter are when SARS-CoV-2 and flus are so contagious.

I've been using a generic nasal inhaler when flying, but it's not clear if that would work in practice.

nitric oxide nasal spray as the nose is the major area to protect

Reading your comment you would believe a nitric oxide nasal spray would be a good preventative when flying?

fffernan• 2 years ago

Even better is to wear a mask (not to prevent virus from coming in that's silly air gets around it) but to keep your nasal passages moist during a high altitude flight. Japanese have known this for years and why they wear masks so much.

SideburnsOfDoom• 2 years ago

winter is when SARS-CoV-2 and flus are so contagious

Influenza may be a seasonal virus, but SARS-CoV-2 is not. There can be and in fact are "summer waves" driven by new variants, not weather.

Source e.g.

https://www.bbc.com/future/article/20240719-why-covid-19-is-...

"Covid-19 doesn't follow normal seasonal patterns, like other respiratory viruses – waves of infection can happen at any time of year."

Angostura• 2 years ago

Is there evidence for this? The typical theory is that during winter, you get more people indoors, in close proximity with poor ventilation- similarly planes is just about a large number of people sitting in close proximity for an extended period.

locusofself• 2 years ago

It sure would have been nice if there was a quality intranasal vaccine that the government could have shipped to each household instead of the insane goose chase that was trying to get vaccine appointments.

shiroiushi• 2 years ago

That's almost exactly what happened with the MEV-1 pandemic of 2011.

Scoundreller3• 2 years ago

I suspect the excessive emphasis on fomite transmission of covid-19 was caused by too many decision-makers (re-)watching Contagion as their “Idiot’s Guide To Handling a Pandemic”.

empath753• 2 years ago

You wanted them to wait until they manufactured enough to send to everyone at once?

Scoundreller3• 2 years ago

There’s some theory that this would have been the best approach so everyone has a lot of immunity all at once and the virus dies out (barring some other non-human reservoirs).

It’s possible an entire population with varying immunity allowed there to always be some reservoir out there.

But good luck immunizing everyone, especially at the same time.

fulafel• 2 years ago

IIRC there were several nasal vaccines at this same stage in development before. Apparently the bottleneck is getting acquired to get enough funding to do the big expensive trials for regulatory approval.

johnisgood6• 2 years ago

Twitter formerly known as X

Given that X is the new name, should it not be "X formerly known as Twitter"?

dools• 2 years ago

Or just Twitter because X is the dumbest rebrand in history.

johnisgood6• 2 years ago

I know, I was just wondering because my first language is not English. I agree that X is an awful name.

modeless• 2 years ago

up to a year or more

So, literally any amount of time?

sethammons5• 2 years ago

“Unlike the mRNA vaccine which targets only the spike protein, CDO-7N-1 induces immunity to all major SARS-CoV-2 proteins and is highly effective against all major variants to date.
“Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.”

This being a more traditional vaccine, I wonder if any vaccine hold outs will be more receptive

4ninesfine• 2 years ago

As a hold out - basically I'm just not going to take it (the vaccine)

jbjbjbjb• 2 years ago

Do you take any vaccines?

jeffhuys10• 2 years ago

More receptive, yes, but not enough in my case.

Sammi• 2 years ago

Why?

ifyoubuildit3• 2 years ago

Is nasal delivery a traditional thing?

Assuming they actually mean that it would stop you from getting and transmitting covid with high probability, and that they're correct, thats a pretty attractive selling point.

But like with any other pharma innovation, I'm not gonna be a part of the first commercial wave, or even the second or third unless I'm incredibly worried about the alternative, which I'm not at the moment (although let's see how hard this thing is "marketed" - am I going to be able to live life without it?).

lbourdages• 2 years ago

It's definitely not new technology, having been in use since the 1980s, mostly for flu.

cbeach4• 2 years ago

I didn't want the mRNA jab (and didn't get it), but I WOULD definitely take this intranasal vaccine as its a classic (live attenuated) vaccine. That class of vaccine technology is not flawless, but it has decades of successful deployment and study.

sethammons5• 2 years ago

To downvoters, really, why?

I asked for opinions and got one and there is nothing non-factual in the response.

My only guess is people have lost their ability (or likely never had it) to separate "it is too new" from "it causes autism"

francisofascii• 2 years ago

I think there is a large percentage of people who got the original mRNA vaccine but don't plan on getting it again, due to being sick for several days or from other "long covid" or vaccine injury fears. So I wonder if that group would be more receptive.

paywallasinbeer• 2 years ago

Absolutely not. I have lost almost all trust (faith?) with medicine. FYI - I'm not doing/using anything wacky like homeopathy. I'm just simply not interested in anything related to medicine anymore. Hopefully another perspective is interesting.

jeffhuys10• 2 years ago

I’m on anti-epileptic medication that allows me to drive again, and to basically be a human again (Carbamazepine). Medicine in and of itself, nothing wrong with it, and we should absolutely NOT disregard it.

However I did lose trust in this one, and I’ll be keeping my eyes open much wider than before. See my other comments on this page if you want to know why.

consteval5• 2 years ago

I'm just simply not interested in anything related to medicine anymore

My mother is this way now and I'm dreading the day it finally kills her. You can't smoke for 40 years then suddenly be anti-doctor. But she doesn't listen to me. Guess she trusts me as much as medicine.

You can't manage your health yourself. You just can't. You don't run your own blood tests. You don't know anything about diseases or disorders. Have some humility. Being anti-medicine is suicide.

nerdjon2• 2 years ago

Unfortunately I highly doubt it.

There might be a small number but when the major problem is misinformation I just don't have much faith in it really moving the needle as much as is necessary.

Given that we are seeing serious problems with people even getting traditional vaccines right now.

For the record: I would love very much to be wrong in everything I said above. But the last few years just don't have me holding out any hope.

bad_username2• 2 years ago

From my observations, the relentless and heavy-handed censorship of "misinformation" created more skeptics than "misinformation" itself, especially in cases where the squashed sources were credentialed medical practitioners and researchers.

AndrewDucker• 2 years ago

"in mice, hamsters, and macaques"

yosito• 2 years ago

This is great! When can I get it?

nottorp2• 2 years ago

“Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.”

That's it's best feature, not the nasal administration IMO.

Scoundreller3• 2 years ago

Is it? I think keeping something frozen is easier than cold but not frozen.

Can keep a vessel absolutely loaded with dry ice in a set and forget fashion for X days.

While keeping something close-to-but-not-frozen requires more active temperature control.

nottorp2• 2 years ago

for X days

It’s about months…

azangru• 2 years ago

Don't live-attenuated vaccine viruses evolve, with a potential to restore their original virulence? Example: Sabin's polio vaccine.

big_elephant• 2 years ago

does anyone know what stage this is in and what the path forward\timeline would be?

johnisgood6• 2 years ago

Is COVID-19 still an issue considering that there has been only 1151 new cases in the US, and 68 in India, and 73 in Germany yesterday? "Only" 7 people died out of these 1151 people in the US, and we do not know the details, I am assuming old age, compromised immune system, comorbidity, etc.

Terretta• 2 years ago

“Is COVID-19 still an issue…?”

Should we devote any time or effort on what to do about the 400 million people affected by long COVID worldwide, with an economic impact of $1 trillion annually?

Is death the only symptom of concern? If the risk of developing long COVID rises with each new infection, is it clear that we can socially and economically afford to ignore it as new variants continue to spread?

How might we reconcile the push to move on, with the reality of millions experiencing debilitating symptoms, some lasting years or even a lifetime? If long COVID can hit anyone, even the young or those with mild initial infections, should we be carrying on under the otherwise useful presumption it's not an ongoing threat?

Whose interests does it serve for governments to be acting as if this problem has gone away, or the opposite?

Article here:

https://fortune.com/well/article/long-covid-cost-1-trillion-...

johnisgood6• 2 years ago

My Government sure loves milking the EU for money to "fight" long COVID.

inglor_cz• 2 years ago

There was talk about intranasal vaccines against Covid in 2020 already. But there was a catch: they need to be tested really, really well.

Anything that gets snorted into your nose has a pretty short path to the brain, with potentially "interesting" results (cocaine, Naegleria fowleri etc.). So you have to be extra sure that your intranasal medication is harmless.

As the article mentions, this particular vaccine has been developed for four years. That seems to be long enough to be sure. But I wouldn't be taking it back in 2021 or 2022.

MostlyStable• 2 years ago

So given that this is an attenuated live virus vaccine, and the way that one gets covid and other viruses is often through the nose/mucous membranes in the nose, what would be the fear above and beyond getting a virus?

I'm not advocating for not testing it obviously, I just don't quite see why we should have an especially high vigilance in this case.

Covid-19 Intranasal Vaccine

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