HN user

phreeza

9,345 karma

my email is thomas.mccolgan at g[oogle]mail dot com

i intermittently blog at phonons.wordpress.com

Working on making better proteins with machine learning at cradle.bio

[ my public key: https://keybase.io/tmco; my proof: https://keybase.io/tmco/sigs/P9gtvzmXYJ6NlWm18exm-PIA-JC6RWYr0qUDqxgitSs ]

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www.flickr.com 6d ago

Locals and Tourists

phreeza
5pts0
www.youtube.com 8mo ago

Solar Powered Drone

phreeza
2pts1
proteinbase.com 9mo ago

Nipah Binder Protein design competition

phreeza
1pts0
github.com 10mo ago

Braincraft challenge – 1000 neurons, 100 seconds, 10 runs, 2 choices, no reward

phreeza
83pts3
research.google 1y ago

Measuring heart rate with consumer ultra-wideband radar

phreeza
1pts0
newstag.app 1y ago

Newstag: News Website backed by prediction markets

phreeza
1pts0
www.futurehouse.org 1y ago

Demonstrating end-to-end scientific discovery with Robin: a multi-agent system

phreeza
3pts0
www.theguardian.com 1y ago

UK Scientists to begin geoengineering experiments

phreeza
4pts0
wyss.harvard.edu 1y ago

Cyanobacteria could help sequester carbon from oceans and factories

phreeza
1pts0
www.euronews.com 1y ago

Thousands go to fake AI-invented Dublin Halloween parade

phreeza
1pts1
www.petercollingridge.co.uk 1y ago

The Mathematics of Dobble (2018)

phreeza
20pts2
climate.benjames.io 1y ago

Solar will get too cheap to connect to the power grid

phreeza
105pts149
judithcurry.com 2y ago

Hunga Tonga Volcano: cause for recent increase in temperatures?

phreeza
2pts0
atelfo.github.io 2y ago

Pharmaceutical blockbusters: the past, present, and future(?)

phreeza
1pts0
www.reuters.com 2y ago

Microsoft, OpenAI plan $100B data-center project

phreeza
3pts0
www.biorxiv.org 2y ago

Whole-body simulation of realistic fruit fly locomotion with deep RL

phreeza
2pts0
lembransation.blogspot.com 2y ago

Ten years of remembering every day that passes (2022)

phreeza
247pts105
old.reddit.com 2y ago

I put a complex codebase into a single 120K-token prompt, and asked 7 questions

phreeza
1pts0
nephewjonathan.substack.com 2y ago

DIY Geoengineering: The Whitepaper

phreeza
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www.msn.com 2y ago

China on track for ultra-high speed trains with hyperloop test 'setting record'

phreeza
1pts0
mastodon.social 2y ago

"We pulled off an SEO heist with AI and stole 3.6M impressions."

phreeza
59pts38
www.carbonbrief.org 2y ago

Low-sulphur shipping rules are affecting global warming

phreeza
3pts1
www.teoalida.com 3y ago

Study: car evolution trends (2015)

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41pts32
sites.psu.edu 3y ago

9-Dimensional Haystack

phreeza
38pts2
www.nytimes.com 4y ago

In New York City Sewage, a Mysterious Coronavirus Signal

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twitter.com 4y ago

“Attention is all you need” has 2x as many citations as original DNA paper

phreeza
2pts2
defector.com 4y ago

Startup Develops Worst Imaginable Way to Get a Cup of Coffee

phreeza
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blog.twitter.com 4y ago

Examining algorithmic amplification of political content on Twitter

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www.pnas.org 4y ago

Slowed canonical progress in large fields of science

phreeza
178pts72
www.nytimes.com 4y ago

Has Delta Peaked? Covids mysterious 2-month cycle

phreeza
3pts0

I think this is a complete misunderstanding of what people mean by taste in software engineering. Taste is more like the System 1 response one builds to code over time, which (ideally) captures the quality of the software beyond surface level, so things like maintainability, composability, readability, likelihood of hidden bugs. This is completely different from the question if the code fulfills the immediate task at hand, but also not the same as pure aesthetics.

Was just going to ask if anyone remembered the name of this one. It was amazing! 15 year old me felt very important/futuristic syncing the news before school in the morning and reading during school break!

Edit: after looking it up with plucker as a starting point I think the one I actually used was AvantGo, same idea though I think.

Is it really that different with the current iteration of AI compared to what was possible 10 years ago? There may be some new awareness at the executive level of what is possible, but I feel like a "slacker detector" or whatever would have been possible with xgboost or lstms.

The most amazing thing to me about Cider-V was that Cider (without the V) actually went away after a relatively short amount of time, when virtually every other internal service that is officially EOL-ed lives on essentially forever.

That seems possible for generating completely new proteins.

Do you think it's also the case for lead optimization where you typically have some degree of measurements around your starting point, and you are expecting to stay in that local neighborhood for the generated candidates, too?

(Disclaimer: former Cradle employee here)

Would you be open to sharing a version of your pitch deck? The main question in my mind is what kind of exit the VCs have in mind when they give you this money.

Doesn't continuous time basically mean "this is what we expect for sufficiently small time steps"? Very similar to how one would for example take the first order Taylor dynamics and use them for "sufficiently small" perturbations from equilibrium. Is there any other magic to continuous time systems that one would not expect to be solved by sufficiently small time steps?

Was leetcode-style interviewing not a thing before that? Cracking the coding interview was published in 2008 so I would assume it was already quite established by then.