jrpt

Instead of going open source, consider selling licenses with Supported Source (https://supso.org/). I made this for the maintainer problem: it's easy to burnout when companies are constantly asking for new features or fixes, while not paying you anything. Why should you work for free so these companies can make more profits? When they start paying you, you're a lot happier about it.

Seems similar to open source bounties, which have been tried in the past and never succeeded.

We've seen something like 20+ years of different attempts of voluntary donations to fund open source, and it never worked. Companies barely fund anything voluntarily.

I'm taking the opposite approach with Supported Source (https://supso.org/) which is this: actually force companies to pay to use the project. Sell commercial licenses. Make it mandatory to using your software commercially. This approach works much, much better than voluntary donations.

Open source funding is broken. That's why I'm making Supported Source (https://supso.org/).

There’s a lot of umbrella diagnoses that would benefit from more specific diagnostics first. What we call Alzheimer’s is probably actually caused by number of different causes depending on the person. This is true of a lot of things in medicine that get grouped together. That’s why testing a drug in mouse models with all the same characteristics sometimes works but fails to translate into humans who have more variety amongst each other.

The same is true of many diagnoses like pneumonia, cancer, alopecia, essential tremor: there’s multiple different groups that would benefit from different things, and if we had better ways to identify the groups, we’d give them what works for them instead of wasting their time with the wrong treatment. As an example, antibiotics won’t work for viral pneumonia and in addition to wasting the patient’s time, actually harm your microbiome. If you had a perfect way to know which is which, you’d always get the right treatment.

Precision medicine takes this even further.

hs-CRP is well known as a useful biomarker and it is cheap to test too. If you look at page 13 of the GrimAge 2 paper, you'll see CRP is one of the factors most negatively correlated with their aging clock, in fact basically as strong of a negative impact as smoking. https://escholarship.org/content/qt6k46n006/qt6k46n006.pdf

This new news is about research published in the Journal of the American College of Cardiology.

It's definitely not some marketing fad.

I would like to know how regular sunlight compares to the combination of vitamin D supplementation and red light therapy. If you do both of those, is that equivalent or better since it doesn't have any damaging effects of the sun?

What do you think about the Nobel prize in physics going for neural networks last year? What combinations of AI + physics do you think will be most impactful and could potentially get a Nobel prize?

"Mayo’s LLM split the summaries it generated into individual facts, then matched those back to source documents. A second LLM then scored how well the facts aligned with those sources, specifically if there was a causal relationship between the two."

It doesn't sound novel from the article. I built something similar over a year ago. Here's a related example from Langchain "How to get a RAG application to add citations" https://python.langchain.com/docs/how_to/qa_citations/

That would not have solved the problem in this fire since wind speed was so high. The videos showed embers traveling far and fast. Having a 10 foot fire break would not have prevented the spread. One thing to look into is how the fire started and if the electrical equipment can be made safer, like being underground in some places.

I made something like this to let people explore the lore of my game. It has an AI act like a dungeon master as you play through a story. You can try it for free at: https://orbsccg.com/adventures

The main game is a strategic collectible card game, but the “adventure mode” is just for fun AI-powered stories.

Even Waymo has external investors. It’s not all funded by Alphabet.

I don’t know why this is downvoted. The lack of profit motive is a big reason that nutrition and supplements aren’t as well studied through rigorous trials as drug therapies. The ones that are run are funded by grants. Rather than just “more funding” I think there needs to be more systemic ways at reducing the cost of clinical trials or using alternate methods of getting high quality scientific data for answering these questions.

For example, there is a good trial running now on ketogenic diet in glioblastoma patients, NCT05708352, I think with a NIH grant and maybe the NCI as well. Here is a video about it: https://www.youtube.com/watch?v=W31kR0MzyRA

Food and nutrition is a big business though.

IEEE Spectrum used to be good. I don't know whether it still is. Does anyone know?

That feature is getting built into the IDE, for example: https://www.jetbrains.com/ai/

Peleton is not a monopoly. Anyone can make an exercise bike. Anyone can offer an online class. I own an exercise bike made by a different company.

I mean it is pretty common to set c=1 though.

There are many cases where you're getting blood drawn already and if adding another test onto that is inexpensive, that's a pretty convenient add-on. That's useful for many reasons.

I was also wondering how it performed compared to a stool test, so I looked it up, and found "While the blood test caught 83% of the cancers found by colonoscopy, it missed 17%. That’s on par with stool-based tests."

It's called a multi-cancer early detection test and they already exist.

There's still value in specific tests, though.

In my experience as a Stanford alum, this is not true. The professors interact with undergrad students all the time.

If you’re seriously considering lying to the CTO you should instead just get a different job at a different company. That’s a really bad working environment if you think lying is acceptable or something to be proud of.

It was probably mentioned in the textbook and you just forgot. I just checked my textbook and it’s one of the first things they say when introducing mitochondria and chloroplasts.

The CEO said on Twitter: "In fact, we built Confidential Cloud in such a way that only you can decrypt your data. Your employer, we as software providers, and the government cannot decrypt your data without your permission, even with a subpoena to do so."

So I think a monthly subscription is the business model, not ads.

The circulation subscriptions were a substantial part of their revenue, however you're right that ads were even larger. I don't think it's fair to say few people ever paid for it though. Subscriptions were important too.

I think a lot of people are willing to pay for journalism, but it has to be journalism above and beyond the basic info that you can get for free online. The basic news is commoditized and freely available online, and that's what a lot of traditional newspapers are competing with. However, paid industry journalism like The Information is something people are willing to pay for - or get their companies to pay for at least.

Also, I think traditional newspapers should position themselves so they're not competing with the lowest common denominator of basic info, however due to cutbacks, most newspapers are in essence not doing very much in depth journalism anymore, which means they are unfortunately positioning themselves as competing with any other source of news.

The recommendation to not do widespread PSA testing is extremely controversial. Also, as an individual, you should make decisions for yourself, not based on some population-wide study.

I think you should always do regular PSA testing, but don't automatically follow it up with a biopsy if it's not that high (just slightly elevated). Instead, do a second-line test like a 4Kscore test, and/or look at your PSA velocity, or look at PHI (Prostate Health Index) scores. Basically, the assumption that "anything over a certain cutoff should be biopsied" is dumb and they should actually just do second-line tests before biopsies, for borderline scores.

Coroners will list immediate, intermediate, and underlying (proximate) cause of death. In that case the immediate cause of death would be say sepsis after surgery, but the proximate cause of death is the cancer. If you are looking at cause-specific mortality I think you do include proximate causes even if it isn't the immediate cause. But like the other commenter said, I think this is factor is so small as to not be impactful.

Come on, it isn’t anything to do with being a “marketing stunt.” Often products like this are expected to lose money at first, but they hope with enough R&D and scale that they can make it successful eventually.

For example, you are pointing out that annotating is costly, but that’s an expense that scales independently of the number of stores. So with enough scale it wouldn’t be as big a deal. Or if they figured out some R&D that could improve it too.

If you're going to go look for devices to help, you should consider something like the Cala kIQ: https://calahealth.com/

It is covered by some insurance and there are also clinical trials that you could get in which would provide it for free.

In that case, you have early onset essential tremor, not age-related essential tremor. I believe only age-related essential tremor has increased risk of dementia. For example:

In an adjusted model, ET cases with tremor onset after age 65 years were twice as likely to develop incident dementia than were controls (RR = 1.98, 95% CI = 1.14–3.45, P = 0.01), whereas ET cases with tremor onset < age 65 years and controls were equally to develop incident dementia (RR = 0.74, 95% CI = 0.19–3.20, P = 0.79).

https://movementdisorders.onlinelibrary.wiley.com/doi/10.100...

However, I think essential tremor needs more research in general.

First off, there's two different kinds: in young people and in old people (known as age-related or late-onset essential tremor). It's the same disorder but evidently different etiologies.

Personally I believe it will be cured with gene editing someday.

Also, it was already known that age-related essential tremor increases your risk of dementia.