itchyouch

I think you hit on a point with git and sql I made in a different context.

Removing friction from the context and flow. For what git and sql do, they arguably have the most efficient and effective work flows for their purposes.

Managing complexity becomes unavoidable for certain problems, so for challenges of the tool, sometimes, it's simple the challenge of the problem.

I would say his point is not articulated well. Tools should be less toilsome and provide faster feedback loops.

I think of "invisibility" as a way of removing unnecessary friction and the author doesn't quite drive home that point effectively.

Good invisibility is like well designed roads. Smooth, clear markings, adequately wide or narrow for the desired speed, easy and obvious signs. Unbothersome and pleasant. Drivers simply drive, rather than get bothered by, "gotta avoid the pothole. Here's comes the bumpy part. That blindspot, I gotta slow down for way too much. Unseen pedestrians pop out here."

This is where invisibility in interstate highway regulations are obvious.

When I see TUI vs GUI comparisons, it distills to friction for a given context/workflow.

I worked in a restaurant with a micros system. It was a very easy to use GUI that was touch screen button driven. A 1 person order could easily be entered in 6-7 button pushes in 2-3 seconds to a seasoned operator: drink > coke > dish > steak > medium > a1 > submit

The beauty with micros was that it reduced the typical navigate > select > add > back-to-navigate workflow into 1-2 button presses with a receipt-like tally providing immediate state feedback.

In this scenario, telling a user to get into a terminal console and type "cd Foo; ./add ketchup" would violate the invisibility principle. It has nothing to do with TUI or GUI.

To me, good tools get out of the way, in the given context. Micros did that.

CLI users are in a CLI flow, thus introducing a mouse to a keyboard workflow violates the invisibility workflow. But for a GUI user to hit up the terminal violates their flow.

Ultimately, all workflows are in search of a faster/less-toilsome feedback loop to the desired goal and tools are in service to the loop. Well designed tools with rabid followings understand through usage where to add friction, and where to cut toil and I'd argue this is where CLIs shine with decades of refinement of the same tool chain.

GUIs are a, it depends on how composable or self contained the given problem for a GUI interface is.

But yes, tools should be invisible. How they become invisible depends.

What’s interesting to me is that the conversational nature of the LLM tends to lead folks down an unproductive convo path.

“Don’t do X” is just as useful as telling an infant not to cry.

When an infant cries, we implicitly understand there is a form of discomfort to address (food, diaper, etc).

To me, when a LLM fails, it signals to me that the architecture and structure of the code is problematic and that needs to be addressed.

Any seasoned dev can usually see non-DRY, non-KISS patterns, then will structure an encapsulation around said pattern to address issues.

I’ve found that this same type of refactoring is needed in LLM code to improve its outcomes, of which then it’s capable of overcoming the bugs.

Simply telling the LLM to refactor for cleanliness in between code generation runs will do so much for maintainability.

I had a very similar reaction.

I went the same way with simply bumping up my bash skills.

Part of me feels like I'd prefer pry loaded with a library that provides shell like methods for doing ruby-esque things.

The trick with the vo2 max measurement on the apple watch though is that the person can not waste any time during their outdoor walk and needs to maintain a brisk pace.

Then there's confounders like altitude, elevation gain that can sully the numbers.

It can be pretty great, but it needs a bit of control in order to get a proper reading.

When considering NAC's mechanisms, it seems that it's efficacy is likely dependent on an individuals's glutathione status.

I doubt that folks with a solid diet, high in sulfur would find much benefit from NAC.

However, as someone who's gotten to use it first hand and have dealt with lifelong, mild inflammation (puffy fingers, clogged nose here and there), it's definitely been a huge quality of life enhancer.

While I can't speak to whether there are enzymes for the proper copy/paste I do have a set of random cancer related bits I've picked up over the years.

There are some basic, well-known nutritional interventions that are generally important/critical for DNA repair processes. The 2 main ones are Vitamin D and Magnesium. Ensuring adequate amount of these tend to be helpful (most folks aren't getting enough sun and greens).

Other than that, a steady and adequate source of the substrates seems to be important: ie protein (nitrogen), and phosphates.

One of the interesting bits about some cancer cells is that while they simply haven't gone through apoptosis, physical sheer stress incurred from physical activity (exercise) can cause cancer cells that travel beyond the tumor point (before it becomes metastatic) to finally self destruct.

It seems important to me that the best strategy for cancer is the compounding of many different strategies that optimize the body's innate defenses to run optimally.

It does seem that ketogenic diets may have adjuvant properties, but there is yet to be a clinical trial that demonstrates it, so it's basically stuck in paper and R&D stages as to whether being in a ketogenic state can be one of the last areas that may help cancer patients extend lifetime from say 1 year to 2 years.

I generally agree. It's all interconnected, and we could point to a singular cause, but to treat them all as one and of the same class of disease seems reductive and not useful.

Though, to be play devil's advocate for a second, it does seem that diabetes is typically where the symptoms start, and we do understand that diabetes is fundamentally metabolic and/or functional dysfunction in 1 or more of 7-ish different areas.

I think it's the level of perspective zoom + timing we take that makes the article's assertion either useful or not.

If we zoom out, while catching disease early on, and we address the metabolic conditions via lifestyle and/or certain drugs like GLP1, then we prevent the need to intervene on the kidney and cardiac front.

But if we zoom in to a specific issue, after disease has progressed a profound amount, a GLP1 intervention may be too little, too late.

Hopefully though, this may help the messaging to folks that if they are contending with metabolic disease that presents as diabetes, introducing lifestyle and pharma interventions early may be helpful on the larger epidemiological front.

While the area under the curve for glp1 administration may be the same, good chance that the story is informing us of a mechanism such as the absorption rate between two different sites.

Slower absorption in the thigh may blunt the immediate peak dosing and the acute hunger effects.

As always, the small details matter. I'd guess that pharmacology also has their own thundering herd problem with the dosing of certain drugs.

One of the interesting bits about pharmacology seems to not be the active molecule as much as the innovations in delivery mechanism.

There were no recommendations.

Usually this type of anecdata becomes the basis of legitimate, controlled studies and over time can inform and/or adjust.

It would be premature to simply write off all influencers or limiting to only accept the medical profession as the immutable truth.

The reality tends to exist somewhere in the middle, outside of a formal proof.

I've listened to many health influencers and among the legitimate and balanced tend to be Rhonda Patrick and Peter Attia.

Attia provides guidelines for how to think about items, but usually it's the fan base that tends to sully the messaging as the base tends to be far more polarized and dogmatic over bits.

It is interesting to see that there is another poster confirming a slightly different effect though. Regardless of things being "systemic", just understanding that fluids dynamics are complex, I imagine diffusion of a systemic molecule like GLp1 could possibly be variable? Or perhaps there is a localized tissue fatigue?

Many potential options do exist to propose as hypothesis.

An interesting FYI is a comment made by Peter Attia on his podcast.

He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss.

They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects.

It seems like GLP1, even in skinny patients (implied by Attia in this particular case), has metabolic benefits.

The longevity community seems to be hinting that there may be geroprotective aspects of GLp1 as well, so we may be looking at the benefits beyond weight loss for metabolism.

I've noticed similar satiation with psyllium as well.

I do a 32hr fast once a week and will consume a scoop of psyllium when I get hungry and it's quite filling for 2-3 hours before the hunger kicks back in.

As an East Asian, not really trying to argue that China hasn’t accomplished great things.

While I can’t speak directly to this, but from watching The China Show on YouTube, the tradeoff to the amazing amenities is that the personal-injury risk from failing infrastructure has been fatal, but covered up by their propaganda. Anyone on the receiving end of it, will deal with devastating consequences, if not fatal.

Infrastructure and manufacturing corners are cut in ways that look great, but literally kill their population and tourists.

Building foundations are not thick enough, buildings aren’t built to proper fire safety standards, underground pipes leak, leading to roads constantly failing, high rises burn down, sewage pipes literally blow up due to methane build up like someone detonated a bomb.

Drainage grates are fake and flooding cities, drowning people in vehicles, while the QA of car battery manufacturing is causing electric fleets of cars in parking lots to burn.

And the aforementioned occurrences are happening in tier1 cities.

I sound hyperbolic, but China is great at quickly cleaning up and quickly rebuilding, so it doesn’t seem nearly as bad as it does.

Once I learned about the infrastructure, I realized my cousin’s business trip accident in China was not a randomly rare accident.

He broke his back in China when his rental car’s front wheel popped off the car.

Chances are most folks are fine if they go. But I would be very weary, because the probability of a disaster is not nearly as high as it ought to be.

It’s likely not a willpower issue as much as the fact that we tend to make choices according to the path of least resistance.

Seems to help to create systems that let us fall to the level of compliance we desire.

Pretty sure it’s the Israeli’s massacring Palestinians. Just in case you didn’t know. ;)

This rhetoric of “terrorists” is getting quite tiresome.

The world has been watching for over 2 years the atrocities occurring in Gaza and Israel and its people have has lost its credibility to its victimhood on the world stage.

This article is simply 1 extra reporting on a million of Israel’s offenses in the name of terrorism.

I think this should be a moment of reflection that the world is waking up to the atrocities of Israel, and not a time to complain about censorship.

I don't really see much debate. The top comments and votes are pretty clearly pro-human.

My recent thoughts on why the US is complicit is that Israel is America's "bad cop" of the world. The trade is that the US will allow Israel to act with impunity in the region as long as Israel gets to be the bad guys to the world.

The reasoning for this is action about nuclear weapons programs. Israel gets to have nukes, developed by sending US expertise to Israel, while Israel has not been subject to nuclear investigation programs.

If things ever got bad, the US doesn't want to nuke the world, then face retribution, they want Israel to shoulder that burden.

The "nuanced" rhetoric to add doubt that things may not seem like what they are, is tiresome at this point. neepi's comments seem reasonable, innocent until proven guilty, but it's simply a strategy to exhaust onlookers with bureaucratic formalities of investigation and prosecution under the masquerade of reasonable justice.

It's a cop out and putting one's head in the sand to the real atrocities of zionistic ambitions of usurping Palestinian land.

In America, if someone trespasses into one's home and the home owner kills the trespasser, the vast majority of the time, the owner is justified and there are numerous court cases we can point to. Recently, it has become clear to me that Palestinians are simply trying to defend their own property/land/humanity.

Israel's trespasses are finally seeing the light in the latest set of conflicts and folks reading this comment that are unsure should spend 30 minutes looking up the videos of the conflict.

Israel blocking aid, murdering medical personnel with impunity, the before/after of Gaza, the list of crimes perpetuated by the government is undeniable at this point.

This article isn't really about whether there's some situation where there were some wrong doings, but it's yet another piece adding to the overall body of Israel's offenses against humanity.

As a random bystander with no real skin in this conflict, other than being American, what I can say is that for a while, it did seem that Israel the country had to unfairly deal with hate and war and it seemed quite unfortunate.

Most of the horrifying stories that would occasionally rise up seemed unbelievable, if not overblown.

Though in recent weeks, social media & news has provided another perspective.

1. Numerous Israeli citizens mocking Palestinians and having the gall to upload it to social media.

2. Numerous classrooms and children being taught that non-Israeli's do no deserve the same human rights as Israelis, and the children from a young age reveling in their superiority.

3. Videos showing citizens in normal cars being a nuisance to Palestinian medical vehicles.

4. Videos showing the absolute decimation of Gaza.

5. Israeli news articles reporting 70% and more of the population supporting certain war actions.

6. Ex-IDF soldiers whistleblowing the atrocious acts they needed to commit.

7. Citizens barbequing and hanging out right along the Gaza's border as Palestinian folks on the other side starve.

8. The video of Palestinian medics getting murdered on the side of the highway.

9. Pictures of the logos on IDF uniforms showing "our promised land" with a map showing borders that claim the land of Egypt, Syria, Palestine, Iraq, Lebanon.

I don't think there is something "broken" in aid delivery. It appears that there is a systemic and concerted effort by the bulk of the government and citizens (100% of who have to serve in the IDF) to colonize and usurp Palestinian land and beyond.

And it seems that the latest set of conflicts have pulled back the curtain on the attitudes held by both the Israeli citizens and government.

For the cost and simplicity, NextDNS is way easier IMO. Nice quality of life apps that install on your phone and computer to toggle it on/off while on-the-go, while also being able to be setup on the router.

Makes it nice and easy for the non-technical members of the fam.

Their view of the attendant as a cog in the machine appears to be a justification for their "learned helplessness" to situations. They've internalized that certain policies they come into contact with in the world are non-negotiable and to attempt to negotiate is shouting into the void, thus a waste of energy.

To them, it's irrelevant whether the helplessness is real or not. So they don't bother to take a moment to poke at the attendant's capacity for resolving the situation to their advantage.

I wouldn't say that its an unusual view, but it may indicate a deep desire for efficiency (don't argue, simply pay and be on ones way), financial privilege (an extra $20 charge is no big deal), or could be symptoms of deeper issues relating to self-worth (I am not worthy to ask for a break).

Interestingly, it was a culture shock when I saw that in other countries (that tend to have a more homogenous ethnic population) informally require photos. Not having a photo on a resume almost guaranteed the resume would go into the trash.

Even more of a culture shock was how much more open people are about their biases in those cases. "We can't have someone short doing job X, or they don't have a friendly face for Y, etc."

Each one was supplanted by the next gen for "coolness".

The next thing after TikTok is going to be whatever gen A/B/C decide are the "cool" platforms. It could be a new 4th or they might recycle an old platform, the way that Adidas and Reekbok and Fila came back for sneakers for a bit.

For corporate social networking, the inertia of "cool" doesn't necessarily have an uncool factor that needs to be overcome in a similar way.

Will be interesting to see how the space plays out though.

I noticed the promise of LED bulbs lasting forever were engineered to fail. I replaced all the bulbs in my house with and about 1-2 years in, many have failed.

Though interestingly LEDs in various components or even LED strip lighting seem to last for many many years.

Le sigh.

Exactly this.

I mostly just buy multiple brands from multiple vendors. And size the partitions for mdadm a bit smaller.

But even the same model where it's 2 each from bestbuy, Amazon, newegg, microcenter, seems to get me a nice assortment of variety.

That's great to know.

It's unfortunate that there's an insanely high number of folks in the population that are taking FQs and running into toxicity without any hope of figuring out what is going on with their bodies.

It seems that it would behoove folks to be able to take the test and know whether they are safe candidates to take FQ antibiotics.

What's actually interesting is that there exists a model for solving obesity. Mostly it's a matter of having the will and prioritization to solve such a problem.

Japan has an obesity rate of 4%. By law they require every school to employ a professional nutritionist, which requires 3 years of additional training on top of their education degrees. In a particular example of 1000 kids, not a single child is overweight. Every nutritionist is required to design the school's food curriculum such that all meals are made from fresh foods and to be balanced according to all the food groups, and they forbid even the use of processed pastes. All meals are made from fresh foods on-site.

Then the kids are then taught how to eat well and to fully cover their nutritional needs from 6-18. This would be the non-ozempic way to influence a nation to eat well.

I'm a big fan of Attia and familiar with his work. That's fair that excess calories is among the major contributors to Healthcare and addressing that would probably be among the largest impact items we ought to tackle.

I wonder though if with the advent of GLP1 drugs, if obesity may already be a solved problem, but merely a matter of time?

I imagine, as with anything, perfect doesn't need to be the enemy of good enough. A huge multifaceted issue like obesity could be addressed from many angles.