evandijk70

The current situation is that the person that doesn't know programming will do it anyway. They will likely make more mistakes than an LLM will.

Not an expert, but I think the algorithm works for any base, not just 10. The python implementation uses base 2^30 for their multiplication. Base 10 is just a convenient illustration

The lookup table would not work for that case

I had access to several health datasets for my research in the past. Date of birth was rarely given, especially for the bigger projects where there were more resources to allocate to privacy protection. Neither was date of death, location, or visits to a health facility with a treatment. Typically the relevant variables are age (in years), treatment type and possibly number of cycles. Probably insufficient to identify someone without access to hospital records. But if you have that, you have all these data anyways.

Most researchers likely would want to summarize these data in a similar way anyway, so this works out nicely.

It doesn't.

The Netherlands has a system with both not-for-profit and for-profit insurers, that works reasonably well.

- Transparent, identical rules for minimum coverage and strict rules on minimum and maximum deductible for all insurers and insurees. - Mandatory coverage for everyone (just like liability insurance is mandatory for cars in the US) - Insurers do not have the right to refuse any applicants based on pre-existing conditions - Insurers directly negotiate with hospitals on rates. Emergency care has to be covered regardless of whether hospitals are in network or not.

During a 50 km hike you are not anywhere close to your VO2 max, so it makes sense that the VO2 max is not predictive for that distance.

I would say that gambling with skill component is still gambling. For example, in blackjack you can limit your losses by following a basic strategy, which is a 2x2 matrix with rows containing the value of your hand and columns containing the open dealer card.

If you can obtain an edge through a skill component (card counting in blackjack), some people wouldn't call this gambling anymore, but I would still call it gambling myself. Someone doing this for a living is a professional gambler.

What for me would be a sensible definition is that a bet/gamble has no other goals. Putting money in the bank/investing in a stock reallocates capital, which can be invested by someone. The fact that it is a risk-taking endeavor is merely a side effect. I would say the same goes for selling/buying insurance for your car.

So for me, the difference between betting and putting money in the bank/investing is that the primary goal is something different than the risk-taking activity.

Because there is little solar in the 3 winter months, so you would need a lot more storage for solar then for nuclear.

Most net worths over $2 mil are created by growth in share value, not by income/salary.

I think this would work for the summer months. Overnight storage is manageble/cost-effective by load shifting/battery storage/etc. This is now estimated at about $100/MWh ($0.10/Kwh).

Seasonal storage is a completely different story. For my own panels, production in Nov/Dec/Jan is about 20% of that in Apr/May/Jun, and this is typical. That means that you either need 15x solar capacity of what you need on a sunny day, or enough storage to bridge those 3 months, two orders of magnitude storage more than we would need to store electricity overnight.

They are indeed fair. The strongest poker bots are not AI in the way it is commonly defined. From my understanding they calculate the nash-equilibrium for a simplified game and extrapolate that to the full game.

In the Netherlands, there is street charging everywhere. It is indeed a bit more expensive if you do not have a dedicated parking place, but not more complicated. By law, public charging has to be available in 'reasonable walking distance' from any EV owner. 'Reasonable walking distance' is defined by muncipalities, and tends to be higher in rural areas. Therefore it varies between a maximum of 150-500 meters depending on municipality.

Normally a long payback time is fine, but I would expect that in ~5 years, faster charging will be prevalent and the current chargers will already be obsolete, or at least less popular.

This article is from 2023

Replace author 2 by reviewer 2 and this is probably what happened.

This is, at least for now, a relatively small market. Illumina acquired the company manufacturing these chips for $100M. Analysis of a genome in the cloud generally costs below $10 on general purpose hardware.

It is of course possible that these chips enable analyses that are currently not possible/prohibited by cost, but at least for now, this will not be the limiting factor for genomics, but cost of sequencing (which is currently $400-500 per genome)

Not just safety, but also effectiveness. FDA checks whether the trial(s) to prove the drugs effectiveness were run correctly (eg. the randomization, the control group, etc.), if the statistical analysis was done right, if the endpoints are appropriate (response to treatment is not always objective) etc. etc.

The FDA (and EMA in Europe) are the only thing that protects desperate patients from fraudsters, charlatans and pharma-companies just looking for a return on their investment.

This already happens, it's called 'compassionate use'

https://www.ema.europa.eu/en/human-regulatory-overview/resea...

Why is that a better fix? Transit also has externalities (pollution, congestion, noise), just fewer than cars.

Do you have any references to these claims?

They already do for a lot of publications. Check the 'reporting summary' in this random article https://www.nature.com/articles/s41586-024-07171-z#rightslin...

Purely speculating here, but perhaps omitting the reason was a condition of the hypervaccinated individual to cooperate with the study?

AFAIK there is currently know way to reliably tell from DNA sequencing data whether a prostate cancer will become dangerous. That may change, but I suspect there may be some inherent stochasticity in the transition of a cancer from benign to dangerous that will make a perfect classification possible. I would guess some form of monitoring may be required for all the currently non-dangerous cancers.

Not a biologist, but won't the tropical amphibians migrate away from the equator? It seems to me that polar bears and penguins have bigger problems

What effect size is big enough for you to worry about? A quick google search shows that smoking reduces life expectancy by 5-13 years depending on the study. Let's say that for smoking, the 'true' reduction of life expectancy from smoking is somewhere in the middle, 9 years. Then, the study I found with the 5-year estimate, is wrong by 4 years.

So, for some lifestyle change to reliably be reproduced by observational studies, it would have to be a 'true effect' of 4 years. I would say that 3 years, or even 1 year, is something to worry about.

Actually, if you would park illegally with a rental car, Hertz would get a ticket. They would just hold you accountable for it.

No. In the event of a bankruptcy, the inventory should be sold to the highest bidder and used to reimburse the creditors of the company (probably the IRS/investors/suppliers).

Bringing scooters to your house would still be theft.

This post shows a good and economical path towards short term storage, on the order of hours to days. The cost of storage based on a daily charge/discharge cycle is about $100/MWh ($0.10 per kWh), which is fine if power is essentially during day time.

However, seasonal storage is a completely different beast. In the winter there are months without a lot of solar. For my solar panels, total energy generated in December is are about 15% of that in June.

Seasonal storage is a lot more expensive than daily storage, because you can use your battery for only 30 cycles (30 years) rather than 1000-5000, depending on the technology used. That means that storing power generated in June and using it in December costs somewhere around 1$\kWh, simply to expensive. Do you have any ideas on how to solve that problem?

Bevacizumab (brand name avastin) for metastatic colorectal cancer (standard of care in the Netherlands, approved by the FDA and EMA and recommended by the consensus guidelines of ESMO https://www.esmo.org/guidelines/guidelines-by-topic/esmo-cli...) and is a well known example. See the response of parliament to a petition to change it now that the patent has expired. NHS will still not fund it and cites cost as an important factor https://petition.parliament.uk/petitions/616742?reveal_respo... . I would note that since funds are limited, any system needs some kind of cost-benefit analysis for drugs to ensure affordability of care. Making this cost-benefit analysis central, transparant, and explicit is probably the best way to do it.

Not GP, but The Netherlands do not move their holidays when they're on a weekend.

If you drive 30k miles a year, yes. I drive 4k miles a year with a car that I bought second-hand 10 years ago for $8,000. EVs are not cheaper for that use case yet.