THC and CBD improve wound healing, may be valuable as skin rejuvenators, study

https://www.mdpi.com/2073-4409/11/23/3939

by hericium • 4 years ago

86 44 4 years ago

h2odragon• 4 years ago

Harvesting cannabis flower involves cutting the individual buds off the stems, cutting off leaves, etc. Close handling. Of generally annoyingly sticky stuff, with sharp scissors.

There are often many minor cuts and nicks and scrapes on the fingers in the process. They rarely tend to be serious, but now I think about it they're not as annoying as papercuts.

Suspect the mechanical "wound glue" action of the resins is more important immediately; and the fact that they pretty much only wash off with alcohol means the wounds are disinfected then too.

latchkey2• 4 years ago

I spent years cleaning hundreds of pounds of weed (1 lb == ~8-10 hours of cleaning, if you're doing it well). Never once cut myself with scissors.

I also used canola or coconut oil to clean the resin off as that worked really well and was an inexpensive way to do it (and seems better than pouring alcohol all over your skin... which would cause it to absorb even more of the resin). Just don't get your hands wet before you put the oil on.

Even though the resin is oil based, you definitely absorb it into your skin. Hours of trimming turns into a spin.

realce• 4 years ago

I also used canola or coconut oil to clean

Ooo that's a great tip, thanks.

encryptluks2• 4 years ago

Your hands don't get saturated in resin unless you're doing something wrong, like squeezing the buds trying to drain oil by hand. It would take a extremely bad trimmer to be continually cutting themselves while trimming. There are a lot of components to THC and CBD that could have beneficial properties, not just the fact that they are naturally sticky.

latchkey2• 4 years ago

My hands would absolutely get covered, but then again the stuff I was trimming was really great quality. ;-) Looking at it under a magnifying glass, all the nodules were wet glimmering, it was impossible to not get it everywhere.

danbruc• 4 years ago

Somewhat related, cannabis might not actually help to relieve pain. [1]

[1] https://www.health.harvard.edu/blog/does-cannabis-actually-r...

bitxbitxbitcoin2• 4 years ago

Acute pain - not chronic pain.

zaps• 4 years ago

What about adorable pain

MagicMoonlight2• 4 years ago

So that would suggest chronic pain isn't real and they just want drugs

scythe• 4 years ago

If you look at the actual paper there:

https://pubmed.ncbi.nlm.nih.gov/36441553/

you will notice that "studies were excluded if they treated patients with [...] severe skin disorders". Which seems relevant in integrating those findings with these.

ltbarcly3• 4 years ago

I heard snake oil is really good for your skin. I wonder if there are any unreplicated studies funded by snake oil manufacturers that we should vote onto the front-page like morons?

(You can check easily that this was funded by manufacturers of cannabis beauty products via MITACS)

chitowneats• 4 years ago

Maybe I missed it, but where in this study does it state that the authors are involved in the manufacturing or processing of cannabis?

Edit: Thanks. I wasn't familiar with MITACS. It does look like they exist to assist industry funding of studies like this.

SuoDuanDao• 4 years ago

I wish people had this kind of skepticism around research by larger pharmaceutical companies.

onnnon2• 4 years ago

I've personally used hash oil (aka Rick Simpson oil) on wounds, and it works wonders.

https://en.wikipedia.org/wiki/Hash_oil

jjtheblunt• 4 years ago

Have you compared it to Aloe, or some control?

I wonder because there used to be a "wormwood oil" from some other plant that I used as a kid and, like you said, it really was great at healing skin abrasions (cuts, scrapes, kids stuff).

onnnon2• 4 years ago

No, but the linked study looked into wound healing and found it to be effective. This aligns with my personal experience.

mandmandam2• 4 years ago

You know, that seems like a rather easy study to do.

Topically apply two compounds to either side of a minor wound and see which side heals faster and better.

Seems like with a large enough sample the truth would become clear pretty fast.

smm11• 4 years ago

Bran cereal was once found to lower cholesterol. What was actually happening was those who ate bran cereal ate less cholesterol-raising foods at the same time.

MagicMoonlight2• 4 years ago

If you're holding a joint, everything looks like it needs one

bitxbitxbitcoin2• 4 years ago

Especially if the cannabis cultivar in the joint is 9 lb hammer by Jinxproof Genetics.

BrotherBisquick• 4 years ago

Sounds like another scientific study that reddit will celebrate while ignoring other scientific studies that make them uncomfortable.

trap_goes_hot• 4 years ago

Its a mistake to think think scientific studies are about establishing facts. Science produces explanations that can be tested. If you never test them, science stops working.

LarryMullins3• 4 years ago

As much as I enjoy cannabis (in moderation of course) I just don't trust any of the medical research surrounding it. The motivation to find medical benefits, to redress the social injustice of people being imprisoned for cannabis, is too strong to ignore. It makes all such research suspect by default as far as I'm concerned.

Anecdotally, I have never found cannabis to be effective at pain relief. I tried it, but it only enhanced my perception of the pain (just as it enhances my perception of taste, music, etc...) When I broke my foot I refused any prescriptions and tried a high-CBD strain of cannabis instead, but it made the pain worse. OTC paracetamol/acetaminophen proved far more effective.

yellow_lead• 4 years ago

I experienced something similar, the pain still persists but it's a bit different, maybe more "tingly" in some way. Wasn't better or worse for me though

the_only_law• 4 years ago

I just don't trust any of the medical research surrounding it.

Same, I tried to do some research about the effects of weed on a certain chemical in the body, and every paper I found had some completely different conclusions.

I will say the one thing cannabis does for me that’s absolutely amazing is as an anti-emetic/anti nausea remedy. Nothing else I’ve ever tried has come close to relieving those sort of symptoms. It does also seem to work for me as a sleep aid, but in the same way as say, antihistamines do (i.e. I’ll sleep, but I’ll have an intense brain fog the next morning)

LarryMullins3• 4 years ago

absolutely amazing is as an anti-emetic/anti nausea remedy

Agreed, cannabis seems to work great as an anti-nausea remedy. I've also found ginger to be effective for this (wikipedia claims evidence for that is inconclusive, but it definitely works for me.)

QuercusMax• 4 years ago

This is 100% true. If my guts are feeling weird and preventing me from sleeping / focusing, THC is an almost instant cure.

feoren• 4 years ago

The motivation to find medical benefits, to redress the social injustice of people being imprisoned for cannabis

(A) There's huge motivation to find medical benefits to anything. Indeed you should be skeptical of any "substance X improves Y!" claims, as they're usually in rats and not reproducible anyway. (If there's an actual backing study at all!) The idea that cannabis is particularly singled-out by researchers with some woke agenda seems rather silly to me.

(B) Nobody needs to prove cannabis is helpful to show that it's an extreme social injustice to imprison people for its use. It would be an injustice to imprison people for drinking soda, and soda is awful for you.

LarryMullins3• 4 years ago

(B) Nobody needs to prove cannabis is helpful to show that it's an extreme social injustice to imprison people for its use.

The specific nature of American federal drug laws concerning cannabis makes dodgy medical research an effective method for breaking those laws down. And the severity of the American penal system makes it easy for activist researchers to decide that the ends justify the means.

RandomTisk• 4 years ago

I've developed a pretty severe allergy to anything cannabis or CBD oil related. It started at the end of 2020 and came out of the blue after taking CBD oil one day. Before that, AFAIK I had no allergy to anything cannabis related. It causes bad respiratory issues for about 48 hours if I consume any and skin hives that take at least a month to fully clear up.

I wish I knew what caused my allergy to appear, whether age, COVID, or something in the oil that wasn't supposed to be there perhaps.

Vrondi• 4 years ago

You may be allergic to something on/in it, such as a pesticide or fertilizer perhaps? Especially if it all came from one processor. Did it come from a dispensary?

smrtinsert• 4 years ago

Didn't they just find that using THC significantly drew out the recovery time after surgery? Caveat emptor.

mandmandam2• 4 years ago

Haven't seen that. Link?

Bet you they were smoking it, as compared to vaping or eating.

Side-bet that they were using isolated THC instead of actual plant.

And even if recovery time was extended - what was the subjective experience of the patient?

Finally, and perhaps most importantly - every time that cannabis gets legalized, opioid overdoses drop significantly. How many people get hooked on opiates post-surgery every year?

eurasiantiger• 4 years ago

If it’s illegal, people are less likely to move from their apartment, leading to less exercise and longer recovery times.

6stringmerc• 4 years ago

Uh, the reason I'm not dead because of the Sackler Family's profiteering is because I studied cannabis and know my strains and my doses. 250,000+ Americans dead, 5x that in family suffering, the single first drop in life expectancy for white males in the country in reasonable working age. And go look at the testimony I found from the floor of the House when they passed the original Prohibition if you like naked racism toward Blacks and Latinos. I found it in a library, they still exist.

It does work for blood pressure, anxiety, pain management, arthritis management, and just being able to relax and let your body heal.

Oh that's right, we have sick-care and a broken fucking system in the US where even maintenance medication (about to be discontinued) was billed at $35,000 a month if you include shipping. I used to get 90 day supplies. Now it's every month. I can only imagine what something newer than 20 years old costs here.

Hence I'm happy to have met some Nepalese and will likely travel to the capitol with guidance from a North Texas immigrant peer who shares the love of Guns N Roses and thinks I'd really like it there. Free health care. They speak English. They like music and don't throw people in jail for that plant that grows naturally in their environment. They might not have pets, but pets are a luxury. I'd rather go to a place that can enjoy an evening of food and music more than trying to get together for some cultish sports thing creating regional rivalries that mean abso-fuckin-lutely nothing.

TurkishPoptart• 4 years ago

what meds cost $35,000 a month? agree with you on your points.

mmerlin• 4 years ago

Maybe those times when a PharmaBro with zero moral compass connived an exclusive supply chain of a previously inexpensive drug nobody else was bothering to make any more, and jacked up the price x10000 for as long as possible to squeeeeeeeze the health system for outlandish profits

hayleyest• 4 years ago

Having read the study, methodologies, and conclusions: This looks like a wonderful bit of science. I appreciate the stepped approach they took to determining a potential best path forward. I find it exciting how it consistently improved outcomes on the wounds. It's particularly fascinating to me that it works in combination with the hydrogen peroxide, and that helps the process, not hinders it (it hinders it without cbd or thc). Assuming the paper isn't a gigantic fabrication to be retracted or disputed, then this is a rather exciting time. I know many who suffer from skin lesions, and even reducing their healing time by 10% would be miraculous. Steroid creams work wonders too, but the toll it takes on the body is severe after the years pile up.

constantcrying2• 4 years ago

Could you explain to me how they arrived at the p values in figure 1? Thank you.

constantcrying2• 4 years ago

I absolutely love how the title suggests a million things more than the study itself. Nothing in the study even could demonstrate any actual therapeutic effects.

Even if the study were one hundred percent well done[0][1] and described a real link between wound healing and Cannabis, it's relevance to the question of any actual benefits in actual human is almost zero. At best it is an extremely weak signal. Of course nobody would care about the study if it was somewhat truthfully reported about.

Please look at Figure 1 and tell me what they are doing. Are they doing what I think they are doing, are they actually doing the statistical test on the whole sample? Without any controls? Doing NOTHING obviously increases \beta-Gal activity, so of course even a treatment which does NOTHING has a positive effect. Are they actually ignoring that? Are they literally just running random data through a statistics program and get excited because they get out p < 0.0001, because their Null hypothesis isn't "no difference", but "nothing changed", which is obviously ridiculous. Please tell me I am totally wrong.[1]

[0] "All anti-aging drugs were dissolved in DMSO and then dissolved in the media before being applied (n = 3 for each condition) for 2 h daily for 5 days." - from section 2.3 in the paper in question. Yes n = 3[2].

[1] I highly recommend reading: https://library.mpib-berlin.mpg.de/ft/gg/GG_Mindless_2004.pd...

[2] Granted, this isn't as bad as it sound, since they try to measure differences of groups of samples.

LinuxBender• 4 years ago

One word of caution with CBD's. If you are on any medications that are metabolized by the liver, CBD's can slow the metabolic process in the liver of your RX drugs and in effect amplify them. Quite a large number of people have ended up in the ER due to overdosing on their prescription drugs without actually changing the dose as a result of combining with CBD's. Making this worse is that some doctors do not know this which can prolong the time to stabilize the patient.

Here is one of the many discussions on this topic. [1]

[1] https://www.youtube.com/watch?v=QYCkVjdgDqQ [video] [58 minutes]

1MachineElf• 4 years ago

In my case it helped as a topical treatment for itching/pain caused by severe sunburn/sun poisoning.

bluenose69• 4 years ago

I don't know anything about this particular MDPI journal, but my experience with other journals published by this group is a bit worrisome.

They often (a) ask me to review papers that have nothing to do with my research activity and (b) ask me to be an editor of special issues that, again, are in fields unrelated to my work. I can think of no well-respected journal that does such things. The other side of the coin is that I know of no serious researchers who submit to, or read, MDPI journals, despite the fact that they have some journals that would, based on title alone, be relevant.

There is a bit of discussion of whether to consider MDPI a "predatory" publisher at https://en.wikipedia.org/wiki/MDPI.

None of this need reflect on the paper in question, of course. Perhaps this particular journal is of high quality. And, even if not, perhaps the paper is of high quality.

THC and CBD improve wound healing, may be valuable as skin rejuvenators, study

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