Overwhelming Evidence for a Major Role for HSV1 in Alzheimer’s Disease (Ad)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234998/

by adammunich • 4 years ago

24 8 4 years ago

ncbi.nlm.nih.gov

adammunich• 4 years ago

This review describes investigations of specific topics that lie within the general subject of HSV1’s role in AD/dementia, published in the last couple of years. They include studies on the following: relationship of HSV1 to AD using neural stem cells; the apparent protective effects of treatment of HSV1 infection or of VZV infection with antivirals prior to the onset of dementia; the putative involvement of VZV in AD/dementia; the possible role of human herpes virus 6 (HHV6) in AD; the seemingly reduced risk of dementia after vaccination with diverse types of vaccine, and the association shown in some vaccine studies with reduced frequency of HSV1 reactivation; anti-HSV serum antibodies supporting the linkage of HSV1 in brain with AD in APOE-ε4 carriers, and the association between APOE and cognition, and association of APOE and infection with AD/dementia. The conclusions are that there is now overwhelming evidence for HSV1’s role—probably causal—in AD, when it is present in brain of APOE-ε4 carriers, and that further investigations should be made on possible prevention of the disease by vaccination, or by prolonged antiviral treatment of HSV1 infection in APOE-ε4 carriers, before disease onset.

ThePowerOfFuet2• 4 years ago

ELI5?

Gravey• 4 years ago

The author of the publication suggests that herpes (HSV1, but also others) is a likely cause of dementia and Alzheimer’s. Especially in carriers of the APOE-4 gene.

leashless• 4 years ago

Cold sores give you Alzheimer's.

Maybe.

dieselgate• 4 years ago

Maybe “Ad” in the title should be edited to “A.D.” it seems like there’s going to be an advertisement

Overwhelming Evidence for a Major Role for HSV1 in Alzheimer’s Disease (Ad)

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