Probiotic that produces lactase enzymes directly in gut

by mataug • 5 years ago

38 26 5 years ago

mataug• 5 years ago

There's some research to suggest that certain probiotic supplements could help with lactose intolerance, but this still seems like there's a need for more research. Curious to hear thoughts / experiences with bactose ?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284493/

Bactories8• 5 years ago

Hi Mataug,

Thanks for posting, we are super small so we notice these things, haha. LA does produce lactase naturally, ours produces about 60% more than other LA strains, and also adheres to the intestinal lining really well, which is why it can last so long.

We have a moneyback guarantee, so if you want to order it on subscription and use the discount code on the site, you can get it pretty cheap, then also if do not like it send us an email to get a refund.

Let me know any other questions or requests.

Kaibeezy3• 5 years ago

$40 a month, and you still have to take 3 a day for a week. Nah. I’ve been dealing with carrying pills around for decades, it’s not that onerous. The price of lactase has come down too, used to be like $0.50 per pill, but I still don’t think I ever took 80 of them a month.

Plus it makes me more mindful of what I’m eating generally, and also encourages me to try and even make new stuff, especially drinks - kombucha, kvass, kefir water, oat milk, homemade syrups for soda, etc.

ihumanable2• 5 years ago

Yea, you can get 180 pills from CostCo for $18 ($0.10 / pill). These seem wildly over priced considering that it defines "long-lasting" as 1 month, meh.

For a year this is $40 * 12 = $480.

Or I could get 180 pills from CostCo (and you could probably source these cheaper) for $18, even if I ate dairy at every meal 365 * 3 = 1095, I would only need 1095 / 180 = 6.08 (round up to 7) boxes of Fast-Acting Lactase which is only 7 * $18 = $126.

This is 4 times the price and for 1 week each month I need to remember to take 3 pills a day. The value prop just doesn't add up, it's not hard to source or have lactase pills on hand.

https://www.costco.com/kirkland-signature-fast-acting-lactas...

Bactories8• 5 years ago

Check out my comment above, but I just wanted to say I am a costco whore, everything from the snacks in my pantry and freezer, to my tv to furniture is costco derived. If you are in Austin, we should go hit up a costco together, I am serius.

Kaibeezy3• 5 years ago

defines “long-lasting” as 1 month

Where’s this? You take a pill with each serving of dairy. I usually carry a strip of 3 or 6 individually packaged pills if I’m out for the day. Each pouch has an expiration date on it, and that’s at least a couple of years, so I leave stashes in the car, camera bag, friends’ houses, wherever.

Even taking 3 or 4 on some days, you’re still right, the cost isn’t much of an issue.

Bactories8• 5 years ago

Our product is about convenience, if you are happy with your current situation then keep doing that. For us it is about taking it for a week and not having to worry about what might have lactose, as well being able to enjoy dairy products in general, without a care.

Also the subscription price is $30 a month, so $1 a day. Convenience holds different value to different people.

Kaibeezy3• 5 years ago

Different value

OK, I can’t disagree with that ;) I’d say your target is people who are new to figuring out they are lactose intolerant and who are most eager to get a grip on it. I was an early adopter of portable lactase, so I’m set in my ways, but there were plenty of days where I’d forget the pills and it got really frustrating: ordering food that looked great but had to be handed to someone else; unexpected whipped cream frosting on birthday cakes; water and cookies. I still run out sometimes and it’s a drag.

I will make a note to ping you when I’m in Austin. Thanks for that. Would be a fascinating conversation.

modeless• 5 years ago

The lorem ipsum on the "journal" page does not inspire confidence. But I definitely believe that the idea is feasible. There's that guy who genetically engineered himself to produce lactose[1] and it worked, and this seems like a less risky way to do it. I'd love for a real product along these lines to come out. Would it even be legal to sell it though?

[1] https://www.youtube.com/watch?v=J3FcbFqSoQY

Bactories8• 5 years ago

We will be releasing our GMO version in 2022. I anticipate its efficacy to be incredible. We will be performing quite a few safety studies ahead of this release.

The site is brand new, please give it time, my cofounder has remade the site 3 times in the past 7 months, he promises this is the last time though (for now haha).

philipkimmey• 5 years ago

I would suggest a deeper scan of the site for copy editing - there’s at least one mention of “diary” when “dairy” is clearly intended.

(I’d probably wait for more usage and supporting evidence before trying something like this, but the prospect of no-regrets dairy consumption is very appealing.)

otterley2• 5 years ago

You can find Lactobacillus Acidophilus probiotics at any health food store, or on Amazon. This is hardly novel - and this one appears to be over 23x the price per pill as the existing alternatives! ($1.90/ea vs $0.08/ea)

tyingq• 5 years ago

Yep. They scale the "active ingredient" image down, but here's the larger version: https://cdn.shopify.com/s/files/1/0590/6667/9502/products/bo...

pazimzadeh2• 5 years ago

They claim to have a specific strain which produces lots of lactase, which is possible. I agree with you on principle though.

otterley2• 5 years ago

The supplements market is full of shysters and charlatans. If they had the actual data to prove it, they would have published it.

beowulfey2• 5 years ago

If I had to guess, this is probably E. coli — BL21 is a well known strain used for expressing recombinant protein.

Bactories8• 5 years ago

It definitely is not E. coli

Bactories8• 5 years ago

Hi my name is Mike, I am one of the cofounders of Bactories, the creators of Bactose.

Our COGS are $10.09/pack shipped first class mail (add $1.80 if we get the custom shipping box). Then we have to spend on marketing, and spend money on making mistakes, we also have robust R&D activity that needs to be funded. This all adds up, we sell each pack $30 or $40 delivered (as low as $15/pack if use coupons on your first order).

I think our marketing sucks, neither me nor the other founder are good at. If you or if you know someone who can help us with the marketing, to drive down our customer aquisition costs, and increase sales so our COGs decline with increased volumes, I will gladly lower the price. I would rather sell 1 million packs and make $1 on each then sell 1 pack for $1million dollars, if you get what I am saying.

pazimzadeh2• 5 years ago

Since the active ingredient here is 5 billion colony forming units of Lactobacillus acidophilus, I wonder how this differs from getting from another source i.e. yoghurt

Through our research, we discovered a novel strain of lactobacillus acidophilus bacteria that will colonize the mammalian intestine and actively produce an excess volume of lactase enzymes

It would be nice if there was a paper demonstrating the claims about this specific strain of L. acidophilus

Bactories8• 5 years ago

Hi my name is Mike, I am one of the cofounders of Bactories, the creators of Bactose.

There are only two things truly unique about our strain. 1) It produces about 60% more lactase enzymes than other lactobacillus strains we tested 2) the really key thing, it is evolved to adhere to the mammalian intestinal lining, this is the crucial point of 1 week of taking pills being able to provide 1 or more months of continued efficacy. If you took other LA strains their effects would wear off quickly, why you not get continued lactase tolerance with them.

Let me know any other questions.

text70• 5 years ago

Have the strains been engineered with a BAC or through CRISPR-type editing or something with Cre-recombinase to get over-expression of lactase?

Any out-patient nutritional studies showing GI intestinal biome data with positive growth conclusions?

prirun• 5 years ago

I had diarrhea problems for a few years that no doctor diagnosed. I found on my own that taking a probiotic twice a day completely fixed it, within a few days. The probiotic (Amazon's most popular) was around $13 for 30 pills, so it was going to be $25/mo.

That worked, but instead of spending $25/mo, I started making yogurt and using a couple of opened probiotic capsules as the starter. I'm also recently lactose intolerant, so I let the yogurt ferment 24 hours to ensure all the milk sugar is consumed by the bacteria. I strain it to make Greek yogurt, which to me isn't as tart and tastes more like sour cream. 2 probiotic capsules and a half gallon of milk costs less than $4 for 2 quarts of yogurt. I only have to eat a spoonful in the morning before breakfast. Works great!

If these lactase-producing probiotics actually do work and are safe, making yogurt with them might be an easy and cheap way to get the same benefits.

Edit: corrected the price to $25/mo

mcc1ane• 5 years ago

https://arstechnica.com/science/2018/09/probiotics-if-you-do...

Probiotic that produces lactase enzymes directly in gut

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