HN user
Mh, balance that ball on your finger while keeping it in spin or dribble it between your legs while spinning your body around and see how many conscious decisions you make while not stepping into canine feces.
Just a comment:
Sounds like a non-issue that can and will be solved or upcycled by people who just think out of that little game theory box.
You are interpreting. And what you are describing is most likely not a function or the result of consciousness.
Pain and fear exist entirely as the return of the CNS. Your consciousness taps into this function to give those interpretations of sensations with external and internal origins properties that support your cognitive processing so that you can make sense (without necessarily creating order) of them in your past, current and future contextS and get to the roots of pains and anxieties to adequately handle them in order to refocus on thriving.
It's like that pain in my leg that dissolves when I stretch and massage it with a Lacrosse ball or something. Or that other pain in my neck and shoulders that disappears when I train through the pain and then massage and stretch those muscles. Some of the things I do to get rid of my pain go against conventional knowledge but I do them because I learned to listen to my intuition which in turn learns from those external and internal sensations and my minds cognitive processing of these sensations.
People with low (levels) of awareness or low consciousness - in most cases entirely the result of stress and or low stimulation - just drop a pill and never get to the roots of the issue causing the pain. That's true even for people with higher education. And many of them have painfully bad medical professionals in their area or "class" and or are treated badly because 'fascism' ...
So getting and or remaining in a state of bliss is quite possible. And you don't have to meditate into it. All you need to do is to learn to understand what your mind and body tell you via senses and consciousness and then find ways to act on this information by getting to the roots of your issues. ( Dreams don't have anything to to do with any of this, btw, not necessarily, because you are sleeping and your senses are mostly off and your consciousness is in an entirely different state )
No spirituality involved at all. If you do take some pills, use the resulting peace of mind to do the workout, the stretch, the processing of painful memories or thoughts. If you take the pill, don't add distractions.
But that's really just another interpretation ;], one that can probably make a few bucks wherever. Feel free to throw me a coin if you do use any of this commercially ;]
I stopped using LLMs entirely. Proper googling, which isn't broken, btw, doesn't cost that much more time, I realised and it let's me have more secondary and ternary related factual info that I didn't ask for, because how would I even know yet?
So spending just a little more time on the (re)search via standard methods provides me with more extensive, fact-checked, reviewed and discussed information than any of the LLMs that I used did.
wtf. this does not sound like complexity, not even nonsense, actually. [ https://en.wikipedia.org/wiki/Not_even_wrong ]
I understand why this wouldn't be anyone's thing.
Do you know of any countries where government employees handled 'the whole thing' adequately?
you can make it work. just think of the many approaches and you'll see that there are actually quite many viable ways to work around pseudo-infinite context.
if-then-high-chance logic is for sex education & prototypes, not for airplanes carrying insured passengers
This general inquiry is strange. This entire rock is asteroids crashing into each other for millions of years and counting.
like the few people we have in the fields are enough to ask all the questions and do all the handywork.
THE underlying function
So this is about where it clicked for me: A function, to us normies, is something consisting of at least one part that doesn't do anything and another part that does something but has no tangible form, 'the operation'. So, to me, irreducible can only mean that there is some level where the function is the thing and vice versa, so that this irreducible function, from our (current) space-time-perspective, has no constituents except 'self'.
Which is nonsense, because self is worthless without stuff it can react with or to. Except, is it really?
A femtosecond can't be experienced because subpixel-sized movements/fractions of reactions happen during this short measurement. But that's irrelevant for the interface between this function and nature and evolution from their current space-time-POV and their, and thus our, space-time-blind-spots. It's like thought and action when there is not enough time to stop a movement or when stopping that exact movement would terminate the intended result.
But I actually don't think that irreducibility is the right term. It should be liminality or something, focusing on the fact that nothing temporary is measurable before the emergence of THE underlying function, which is what I used to think The Planck length is for (more or less) constant space.
you'd want what exactly? 10 times more small satellites in the {or}bits (i never noticed ...)?
for science. but i think he's gonna time it perfectly with his natural death sometime far off into the future
here's how i shifted that paradigm:
have 1 item per list and no more, with only 3 priority levels: on deadline, life, wonderland.
make sure to stack whats finished.
'reorganize' lists you didn't get around to yet, regularly; just to know what's on them in case you ever stumble upon something that might extend one of the puzzles around those wondrous subject and objects on your many lists.
Same in Europe. The obesity itself is just part of the problem. Negative effects on cognition, willpower, stress hormone levels, "fatigue" and so on.
It gets people into moods, the blood sugar levels and the stress hormone levels. Makes it easier to sell your product and your story. More stress at work, at school and then at home. Less peace equals striving for compensation and submitting yourself to something that gives you that compensation. It's a brutal story.
A tiny deviation from baseline levels is enough and that's exactly what the dietary guidelines resulted in. It was an "unintended" side effect for some time. Then there were patterns.
They killed the very people who would have made it work a few decades earlier. However motivated ...
Singapore
thank you for your memories.
Reminds me of those kids who forget their lunch in their backpacks when the summer holiday starts and find it again 6 weeks later.
or the ones currently present, hyped, in trend? wait, I suggest: amplified/augmented attachment via exposure.
the classic tale of the "make it proprietary" trolls. uuh! someone should make it a paper chase all the way to insurance companies!
on a subscription basis?
depends. DIY or that mid priced stuff from the supermarket?
Great to read someone wants to scale this!
It would be amazing if the tech to test samples of anything edible could become a target of the DIY & Maker community. This has to be a citizen science effort.
Production results vary. Just recently an acquaintance who owns a small coffee shop in a small town got a visit form the local public health administration telling him that they got a notice from a company that he purchased a product that is being called back due to xyz.
We were all surprised that this system works so incredibly well.
But in terms of health, there are just too many factors that impact individual bodies and brains while being barely relevant in samples of the general population. We need to build a database of human profiles whose health was impacted by something in their food. Of course, there's allergies, and nutritional coaches, and so on but those processes are incredibly long and people get lost and give up or often enough, nothing is found and the person is left to his or her own devices.
I have a friend who reacts bad to some dairy products, whipped cream for example, but the intensity varies with the producer! And he tried some of the most expensive products and some are 'ok' while others produce pain. There must be traces of something that is simply not looked at when tested by food safety labs. And labs like that of the dude from the article are rare and cost a lot.
A couple of weeks ago someone mentioned fertility rates and why some generations had worse ones than others. Not birth rates, fertility rates. Apparently there are periods in time where causes for worse fertility can't be deducted from research and economic data of the time. Microplastics and such didn't play that big of a role back then and the water, soil weren't even remotely as bad back then. Pre WW1 to post WW2. So I proposed it must be something that was in the food that nobody looked at. Might even be sabotage, who knows.
So yeah, I really hope the Maker community can up the game a little and pave the way for more citizen science in food safety and in the research of how different compounds &/or combinations impact energy metabolisms.
missed opportunity. the kids rigs on the first picture could have been running DOOM
Yes, 100%. But apparently, there are cases where fluoroquinolones cause long-lasting oxidative damage or mitochondrial dysfunction. The recovery of mTOR signaling then may be slower.
Even after the cessation of fluoroquinolones, prolonged oxidative stress can lead to chronic inflammation and collagen synthesis may remain impaired.
Ongoing mitochondrial damage can reduce the cell's capacity to respond to anabolic signals, potentially leading to prolonged weakness in connective tissue and a higher risk of tendon damage. The slow recovery of mitochondrial function may lead to extended mTOR inhibition in tissues like tendons and ligaments.
This bit is especially interesting:
Fluoroquinolones also impact dopaminergic and adrenergic systems, which regulate the body's stress response (via dopamine and norepinephrine). This disruption can affect how the body handles both acute and chronic stress, with potential long-term changes in the hypothalamic-pituitary-adrenal (HPA) axis. Dysregulation in the HPA axis could affect cortisol production, impacting inflammation, immune function, and tissue repair over an extended period.
Long-term impacts and the systemic nature of chronic inflammation, mitochondrial damage, and persistent oxidative stress can lead to structural or functional deficits in tissues that were secondarily affected during the acute phase of stress and disruption, which can manifest as persistent dysfunction, pain, or delayed healing.
Agree. Quercetin did help with recovery, but so did eating the equivalent amount of foods that contain it: Red Onions, Red Grapes, Berries, dark green veggies. Rather a lot of those of course, about 1 to 1.5 kg combined. I remember the clinically effective dose to fight colds and so on to be 500mg, but my body dumped quite a lot of that into the toilet, so I halved the dose on another occasion and the effect was the same and I recovered quicker that when not taking it. But again, those foods in adequately high amounts did enough, probably because they also give energy, vitamins, minerals as well.
Agree on the collagen as well, especially for recovery after injuries and after surgery.
One equivalent of motivated reasoning would be confirmation marketing or motivated consumer reasoning, where messages/information align with the pre-existing beliefs, desires, or emotions of the target audience, leading them to favor a particular brand or product, presidential candidate or CEO.
My only problem with all this is how some conspiracies are simply oligarchical coordination and consensus, use/abuse of structural power, institutional capture, soft power manipulation, systemic social engineering and the like and while there not being enough energy behind educating people on these topics is entirely a fault of people like me and journalists, I feel like engineers owe it to themselves to build tools and platforms that target & track these "entanglements", entirely for the fun of the game & to strengthen the upper ranks.
I don't accept the upper ranks to be 'Elite'. An Elite doesn't break with systems, bankruptcy or crashes in the stock markets. So if the people can make the game harder for them, maybe our neo-evolution will select the fittest in the game, rather than the most corrupt, depraved, oppressive, exploitative, malignant ...
damn it! guess I was too serious for a bit ...
But yes, on another occasion I went with "we should totally send them all to space if they want it so bad", too.
Although, for the fun of it, I feel like he was cooler in his pre-Torso times [0], so maybe it did something to him and somebody should remodel it to something less tanky and protective so that he becomes more responsive to the signals of burning, bleeding, coughing, boiling from toxicity nature... maybe growing his hair would help. I heard Native Americans did it to receive the Universe' Radio better.
[0] https://knowyourmeme.com/photos/2407264-elon-musk-shirtless-...
Have you tried a 3 to 6 month long retreat at an organic farm with no supps and only the meds that you really need? You can bring your gear and build games there, too.
I wanted to dive into the production of all the different supps for a while but intuition tells me it'll end up in some reverse confirmation bias aka "job security and esoterically enhanced anti-pla-no-cebo thinking" ... and that kills my mood.
1. What causes ciprofloxacin (or its class fluoroquinolones) to harm connective tissues?
mTOR Signaling
Fluoroquinolones are known to affect the mTOR (mammalian target of rapamycin) pathway, which is critical for protein synthesis, cell growth, and tissue repair. mTOR integrates signals from nutrients, growth factors, and energy status to regulate cellular anabolic processes like collagen synthesis and fibroblast activity. However, fluoroquinolones can induce oxidative stress and mitochondrial dysfunction, which may disrupt normal mTOR signaling. This interference can impair the normal anabolic functions of mTOR, potentially leading to diminished protein synthesis and weakened connective tissue repair.
Mitochondrial Dysfunction
Fluoroquinolones can damage mitochondrial DNA, which may reduce ATP production and impair cellular energy homeostasis. Since mTOR activity is energy-dependent, reduced ATP availability could downregulate mTOR signaling, inhibiting processes like fibroblast proliferation and collagen synthesis. This could explain the tendinopathy and cartilage damage sometimes associated with fluoroquinolone use.
Collagen Synthesis and Matrix Remodeling
The anabolic processes that support collagen production and extracellular matrix (ECM) remodeling are crucial for connective tissue integrity. Fluoroquinolones have been observed to impair collagen synthesis by disrupting the fibroblast function, and this may be due to their impact on the energy-intensive processes governed by mTOR.
Fluoroquinolones have also been reported to cause central nervous system (CNS) effects, including anxiety, tremors, and other neurological symptoms, suggesting an impact on adrenergic pathways. This dysregulation could interfere with normal stress adaptation mechanisms, including the modulation of inflammatory and regenerative processes in connective tissues.
Connective tissue healing depends on the body’s capacity to manage energy demands and stress responses during recovery. Fluoroquinolones can impair mitochondrial function and create an energy deficit at the cellular level, reducing the ability of fibroblasts to engage in critical processes like collagen synthesis and ECM remodeling. The systemic impact on both dopaminergic and adrenergic systems can further weaken the body’s ability to manage stress and energy during recovery, exacerbating the negative effects on tissue repair.
Fibroblasts and Collagen Production
Fibroblasts are the key cells responsible for producing collagen in connective tissues. Under conditions of oxidative stress and energy depletion, fibroblasts may enter a senescent state, reducing their capacity for collagen synthesis and matrix repair. This can lead to weakened connective tissue and increased susceptibility to injuries like tendon ruptures, which have been reported with fluoroquinolone use.
Collagen and Tendon Health
Fluoroquinolone-induced dysregulation of cell signaling, energy metabolism, and oxidative stress management all converge on a critical issue: the weakening of collagen structure and connective tissue integrity. This has been particularly evident in the association between fluoroquinolones and tendinopathy or tendon rupture, likely linked to the disruption of collagen synthesis, the downregulation of mTOR, and the stress on connective tissue cells such as fibroblasts.
Some Sources:
[ ] https://academic.oup.com/bmb/article/130/1/39/5366272
[ ] https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra1...
[ ] https://www.frontiersin.org/journals/physiology/articles/10....