verulito

Been a while since I did fmeca work but it used to mean different tolerances for the parts.

antibiotics are toxic in general, likely affecting way more than bowels. many are ototoxic for example.

Also in Austin. We should have a HN meetup or something.

That's awesome. So happy for her and all the others like her who now have hope.

Anyone who understands the treatment, do you know if the reverse is possible too? I have hyperacusis and could benefit from deafening, esp if it's easily reversible.

The best we have now is disrupting the ossicular chain. Other than surgical risks, it's not fully reversible.

Having (Jewish) Israeli, pre-Israeli, and pre-pre-Israli heritage, I don't personally find "From the River to the Sea" offensive but I do find it non-constructive and insensitive. Globalize the intifada otoh is awful.

I follow this topic daily, on twitter, in telegram (both Israeli and Arab groups), and among the thousands of Jews I know across the world on FB (from anti-Zionist Jews to Orthodox). This is the first time I've ever seen the phrase "Greater Israel" mentioned. I'll go research it now but it strikes me as a manufactured obscurity, while "From the River to the Sea" is prevasive.

My aunt lives in Tel Aviv from 1933 to 1952. She told me they actually started shelling the city that night, not the next day.

As well, there was fighting in the streets. They had to turn off the lights at night and hide in the basement to avoid raids. There was a sniper who was shooting at their apt from a nearby mosque and they would find shells on their balcony. They lived on Ben Yahuda St.

Just thought readers might appreciate a first hand account of what it was like to be a Jewish Israeli at the time.

Can confirm. A crypto bro / lawyer invited me to learn to shoot. I hate guns but figured it was a way to spend time with him. The result is I now have noxacusis, a repetitive stress injury of the ear.

At times I've been unable to tolerate everyday noises like talking or faucets. An unstudied condition that's hugely disabling. The other person in my city with this condition lives in a closet 24/7 with earmuffs.

What's his excuse? "I'm a libertarian and I don't like when gun ranges bother me. I just want to get out there and shoot". Dumbfounding.

So he never planned on gaining if the company was successful? What a dumb argument

I have a rare disorder called hyperacusis from a noise trauma, which causes pain from everyday sounds. While I'm thankfully not sensitive to these kinds of sounds, most are and it's quite dangerous to us.

This disease is repetitive stress injury, in that every time you experience pain it lasts for weeks or years even and your sound tolerance goes down. So it is imperative that we never have accidents like those that cars like these can produce.

It can get so bad that you can't tolerate even simple things like the sound of sheets. The other patient in my city is confined to a closet 24/7 with earplugs and earmuffs because his tolerance is so low. He continues to worsen because sounds like these penetrate buildings well.

It is nearly unstudied so there's little hope of getting out of this hole. The least society can do for us is protect us from these assholes so we can hide in closets in peace.

I have a medical condition that makes me sensitive to everyday noises. It started when a friend invited me to learn to shoot but was complacent about my hearing safety.

Lots of conditions have pain from sound but this is no ordinary condition. It is highly unstable and degenerative. Something is broken, the more broken it gets, the more easily it gets broken, and the longer it takes to heal, if at all. Many of these patients are stuck indoors 24/7, with earmuffs and earplugs, afraid of even the slightest sounds. Even then, they still get a myriad of symptoms, different kinds of pain, autophany, visual snow, distortions. Most have tinnitus, myself included, and it can be very, very loud. One poor guy has 50 tones. Another woman hears it in her sleep.

All these people want to live but this condition is living torture and you end up living like a caged animal. We have no idea what causes it and there's little hope of improvement, given that it gets virtually no research money. No drugs exist which can mask the pain. Many of these patients end up going because they truly have no options, no hope, and living has become unendurable.

Thankfully my hole isn't so deep yet but I have decades of dental appointments and MRIs to endure. As long as I mostly stay home and avoid nearly all social interaction, I can probably hold out a long time before I get that bad. However, I also have mystery tendonitis and other pains that are getting worse so idk. My mast cell labs are all very abnormal so I'm thinking it's auto-inflammatory.

Mayo clinic is a waste of time I hear for stuff like this. I'm going to try the Metrodora institute, see if they can come up with something. Nervous that I may worsen from the flight and end up stuck there.

I have chronic tendonitis in my elbows and hands. They say it's non-rheumatologic but don't know what it is. How frustrating medicine can be.

There is no specialty in medicine for treating undiagnosed diseases. You just bounce around between doctors until you give up.

That'd be true if it weren't for cheap leverage that you get with real estate. 3%/yr with 5x leverage is 15%/yr

I think PrEP is great and I don't think we do a great job of getting it to people for whom it makes sense. That being said, the CDC has an excellent position on who should be getting it and that's not a lot of people.

PrEP is well tolerated given it's known side effects but conservative medicine dictates that we don't prescribe medications unless we have a measurable benefit and that's not a large group of people. A homosexual male who has lots of unprotected sex with strangers should probably be on it. A hetereosexual mostly monogamous person probably shouldn't be.

A big factor here is that the prevalence of HIV in the US is low, at .34%. Globally it's a bit higher at .48%. It is also often not that contagious. That being said, under the right circumstances it could be so it's real important to be aware of the risk factors.

I agree with other comments. He was careful with his wording to reflect how he feels, without blaming others.

I feel bad for OP here. It sucks and you deserve the same love and affection that everyone else does. Your needs and desires don't change just because you have this disease. I would like to point out that while PrEP might not do it, a vaccine might. And a vaccine seems very plausible in the near future given how close we've come with drugs.

this!

Because one is not better than the other. They perform complementary functions. Hence, I would suggest either finding time for both (I don't) or alternating.

That is, one day you sleep more and don't exercise and the next day you sleep less and exercise.

Well, there's that crazy guy who's trying to make it available to the public for at home experimentation. He already tested it on himself, trying to get himself bigger muscles as I recall. One of the comments I saw from a microbiologist included the words "the most cancery cancer that ever cancered".

Those kinds of business plans were typical of that era and venture capitalists were accustomed to investing in lofty dreams. Naturally, it didn't pan out most of the time and they've gotten smarter. Theranos managed to outlive most of their peers, it seems by turning to deception instead. From my reading, it seems that the failures are old but the crimes are recent.

Mine were removed when I was 2 because they were huge! Like all surgery, it comes with risks and tradeoffs. It's great that we have a better idea of what the risks are now but that's not a reason not to do the surgery. Let's not forget that it's still a well tolerated procedure that confers some benefit to the right patients. We're not removing them for fun.

What benefit is that? Large tonsils occlude the airway, causing sleep breathing disruptions. The impact of those disruptions isn't visible but we know it is very harmful, particularly to children since they're still developing. We can avoid those developmental problems by removing the tonsils. I don't want to go into it here in too much detail but "developmental problems" is not a small thing, we're talking about structural changes to the skull, learning difficulties, behavior problems, etc.

An open question is how bad does the occlusion need to be before it justifies removing the tonsils. I don't know the answer to that question. I'd say bad. And that happens increasingly often because large tonsils have a strong correlation with allergies to begin with. Chronic infections are more a complication of the original problem, not the cause of it. And that's not even touching the damage these infections can do to the sinus cavities.

Just checked the rankings. My first high school made #172 on the list ("International School of the Americas").

My second high school is unranked ("Texas Academy of Math and Science"). I don't think it qualifies as a high school. Seems we haven't done a great job of identifying the accomplishments of our alumni, based on the Wikipedia page. No doubt it would rank near the top though. My year alone Caltech accepted about 30 of us, more than any other high school in the country. Makes me wonder what my peers have been up to.

Anyway, I'd agree that these tech high schools have some amazingly smart people attending them.

2: https://en.wikipedia.org/wiki/Texas_Academy_of_Mathematics_a...

There's also skeletal changes with age: the facial skeleton shrinks starting in our 40s-50s.

Got a reference for severity claim? That measured in terms of AHI or significance of the events?

We don't build housing, builders do. We simply decide what is permitted to happen. We could eliminate restrictions on construction and that would help but the rate of housing growth would still be limited by money available to pay for new housing, which is a lower bound to affordability. It's actually a worse problem than it sounds for, if we're decreasing building restrictions then we're slowing price growth and decreasing the attractiveness of housing to investors. To accelerate affordability, we probably also need to subsidize or at least incentivize then.

That gets to be fairly expensive so where's the money going to come from? My proposal is a national growth tax, whose money is redistributed from areas which don't grow to those which do. That money will be used to pay for infrastructure improvements needed to house those people as well.

My company has an anonymous internal forum and I don't even like asking simple HR questions on there! I once complained about my disuse of my dependent care FSA going unnoticed. That's as far as I'm willing to go.

A touchy subject like this from someone with a technical background to a large group of people... I guess Google has a lot of employees and it was bound to happen eventually but seriously, how do you hit send on something like this without some twinge of anxiety?

While we're at it, we should also add sleep apnea to the list of disorders to screen for. Sleep apnea causes anxiety. Estimates of prevalence range from about 1-2% at the low end to 30% for certain demographics. And increasing with time due to changes in the facial skeleton. Diagnosis rates remain low because the symptoms can be difficult to trace back to it and there's low awareness among doctors still.

I can't find the source code. Anyone else? Looks like a competitor to Grid Engine or LSF.

I think people also forget that it's not as simple as taking a pill and all is good. All medications carry side effects and risks. Even Tylenol can cause major problems like hearing loss down the line. As I recall, the life expectancy of this cohort is close but still below the general population. This difference is probably a reflection of a lower quality of life, which don't ultimately take their toll for a long time. There's also the ongoing risk that the drugs may fail to work at some point or that the patients may not be a good candidate for them or there may be interactions interfering with other treatments.

Because it takes many years to build cases like these. It may still happen.

Actually, it turns out that they also fabricated data on their test (Herpes I think) and they ended up having to send out letters to tens of thousands of customers who got false positives. They must be pissed... think of all the damage those have caused.

We should also remember that she graduated like 15 years ago, about the same time I did. The world was VERY different back then. Her style of management reflects the generation she was created from. Unlike her peers, she was unlucky enough to have had access to enough funding to last this long. As a result, the damage done is larger than was typical even back then but also ending at a time when it would stand out. Companies like Theranos collapsed all the time in SV in the late 90s and no one thought anything of it as a result. It's not an excuse but from the looks of it, her hole was too deep by the time trends change to do a course correction.

Let's also not forget that she pursued a vision that was severely flawed, no different than many college students today even. She made a lot of mistakes that many of her peers made at the same age. She's just really unlucky at this point.