strontian

wow, love the look of your game!

You may consider that you have a dust mite allergy. If you have any of: chronic coughing, frequent sickness, eczema, or IBS then that is even more evidence this is your problem.

Basically a two step process: 1. Keep humidity at 40% year round, using dehumidifiers. This stops their biology and makes them go dormant quickly. Their eggs and protonymphs will die out after a year or so. 2. Remove existing allergens from your home. In short: allergen covers around your bed, get rid of old fabric stuff(curtains, rugs, carpet). Launder everything you can on the highest heat possible.

Basically a two step process: 1. Keep humidity at 40% year round, using dehumidifiers. This stops their biology and makes them go dormant quickly. Their eggs and protonymphs will die out after a year or so. 2. Remove existing allergens from your home. In short: allergen covers around your bed, get rid of old fabric stuff(curtains, rugs, carpet). Launder everything you can on the highest heat possible.

I've read hundreds of dust mite studies, and this is the conclusion I came to, but it's difficult to put in a direct single argument with a citation that most people would require to accept it. I also got dust mites entirely out of my home and my chronically low vitamin D was resolved without a change in lifestyle or supplementation.

But I'll do my best to share some of the steps toward this conclusion:

#1. There is a body of molecular research showing dust mite allergens directly damage the immune system, most importantly once you inhale their fecal pods, they cause epithelial permeability in the lungs. (this study is a good overview of several ways it directly damages the immune system, all of which are totally unrelated to type 1 hypersensitivity, btw: https://www.jacionline.org/article/S0091-6749(18)30848-0/ful...)

#2. There are challenge studies that show dust mites directly causing eczema symptoms after inhalation, which shows that dust mite allergens can act on areas other than the respiratory system, probably by entering the blood stream. Of course there are also challenge studies for asthma. (here's a paper arguing for causal role in asthma https://www.atsjournals.org/doi/full/10.1164/rccm.200811-175...)

#3. All of the major allergic diseases(asthma, eczema, rhinitis, and although it is not as well studies, I believe IBS) have epithelial damage and increased allergy as a core feature of the disease. #1 and #2 are good evidence that dust mites play a causal role in these diseases

#4. From asthma and epithelial permeability in the lungs you can get to worse outcomes from flu and covid etc, from rhinitis you can get to worse sleep and worse mental health etc and reach a large number of health outcomes.

#5. It's true that people with allergy suffer worse from all these problems, but so much damage has already been done before you even get to Type 1 hypersensitivity, but that's another story.

So basically, dust mites directly damage your immune system in the lungs, skin, nose, eyes, guts(and maybe more?), create a sustained immune response, and leads to a multitude of other bad health outcomes.

And since low vitamin D is associated with dust mite sensitization((https://www.worldallergyorganizationjournal.org/article/S193...) , it's also associated with all those other bad health outcomes that are actually caused by dust mites.

People have a mental model that vitamins are at the root level of causality, and therefore don't consider that vitamin D could also be caused by dust mite exposure.

IgE levels are inversely associated with vitamin D: https://www.nature.com/articles/s41598-020-77968-1

But supplementing vitamin D doesn't lower IgE: https://publications.aap.org/pediatrics/article/150/Suppleme...

And of course high IgE is directly caused by exposure to dust mites if you're sensitized.

I don't know the specific mechanism by which they cause low vitamin d, but two possibilities are that #1: the high and sustained immune response your body runs from constant dust mite exposure consumes vitamin D and acts like a leaky bucket. #2: dust mites somehow disrupt vitamin d production in the skin(e.g. there was one study showing https://www.jacionline.org/article/S0091-6749(13)01768-5/ful...)

No one will probably believe this, but I think dust mite exposure is a major cause of vitamin D deficiency and a lot of the negative outcomes associated with low vitamin D are actually second+ order effects of dust mite exposure. Just posting in case it reaches one person out of the 100s of millions who are sick from dust mites.

i love this so much <3

Me too! Because dust mites? Curious to share notes with you, I’m running 4 aeockys right now but they don’t seem to last long

I made a free copy/paste helper meant to help get multiple source code files into LLMs. Just something simple to give more granular control over context and work with other ides eg xcode

pastybara.com

Hah! Glad someone else wants to try this!

In the early days, populations of eggs and protonymphs are high and perhaps you haven't learned to control humidity in different weather conditions, washing 2x a week will be effective imho.

But if you can maintain low humidity for a longer periods, the dust mite populations in your home will go down and frequent washing will be less important.

thanks for letting me know my email fwding is not working. Twice a week. Be sure to wash as hot as your machine can do. I found that the highest setting on my front loading LG washer does 158f and is more effective than the next hottest setting.

I have asthma symptoms from dust mites, and discovered that sniffing items creates a reaction in my lungs that is pretty sensitive to the amount of allergen in the item. Dust mite allergens also have a distinct but subtle smell you can learn.

Regarding whether or not your health issues are caused by dust mites, if you have any of the allergic disease, or if you have a tested dust mite allergy, it is likely they are causing problems. Disease severity is also associated with dust mite exposure.

Basically, the worse you have allergies, the more likely it's dust mites.

It's an almost certainty you home has dust mites and their allergens, unless you live in a very dry climate.

My advice is to create conditions in your house in which dust mites cannot thrive, which is relatively easy to verify with hygrometers. Over time, this will lead to lead to lower allergen levels, particularly if you are proactive about removing the ones that are currently there.

nice! I recently got dust mites out of my home completely, and it was a miraculous upgrade to my health, including several symptoms that are outside the definitions of allergic asthma/eczema/rhinitis.

One important thing people are missing about dust mite allergy is the many ways in which they directly damage your immune system and body, outside of the usual frame of "allergies" which is based on type 2 hypersensitivity.

This article is a great introduction to the harms they cause at the molecular level: https://www.jacionline.org/article/S0091-6749(18)30848-0/ful...

I also wrote a free guide to help people get dust mites out of their house:

https://dustmiteguide.com

I'm curious whether anyone has written much about this subject as it's very interesting and rarely discussed.

I've done this a few times and overall it went better than working with a stranger-founder.

ALTHOUGH - You should understand that, independent from the various forms of risk the business faces, and also independent from the financial risk and uncertainty you face through your agreements with the startup:

1. The social fabric of startups are highly unstable for the first few years.

2. The beliefs the participants have about the world, the other people in the organization, what to do, and so on is also highly unstable.

Your relationship is a minor player relative to the other(sometimes chaotic) forces affecting the organization, however generally it works in your favor.

Also, the normal rules for navigating a startup are still apply. Of those, the most important is selecting the right startup to join.

Any specific examples you like for automation?

Thank you for making this! I’ve been dissatisfied with the options available for making local GUIs and curious about what could be done with game engines. What was it like working with the UI layer of Godot?

Anyone have cogsci or neurosci reading recs?

Thank you, this type of info is rare to come across and much appreciated

Just seconding this comment. RefactoringUI is a far outlier in how _useful_ it is compared to other books.

Watching videos serves a diferent role than interactive b/c you get to take in audio and visual together, which _can_ support a higher bandwidth learning(depending on quality of the video). Also, for unfamiliar subjects, it’s useful to be exposed to the concepts and constructs first so you can build a mental scaffoliding that supports the details. Speech seems to be a better medium for that.

Interactive, like other info sources that present info linearly and in high detail are much less efficient, but allow you to learn the ‘doing’ aspect that a video would not.

But I am curious about what you’ve made. How has the reception for this type of info product been so far?

ah I see it is webgl and codemirror. But if you have anything else to share about the making of the site would love to hear!

wow this is delightful! Is there anything you can share about how you made the page? Are the graphics in webgl? What did you use to embed the code?

I’ve been recording voice notes to work through problems on walks for about a year and I love it.

There are other transcription apps out there, but they are all focused on b2b, so I have been making one for individuals.

https://www.glowvoicenotes.com/

It’s still pretty early days(first version should be available in about a week) but I would love to find anyone out there interested in using voice as part of their work flow, there are a few different directions it could go in terms of features.

Thank you!

Subnautica -

It’s an open world survival craft game set underwater on an alien world.

The basic gameplay mechanics of diving underwater, having limited oxygen, light and time create an immersive baseline experience. It’s scary, exciting, and fun.

The core gameplay loop is about exploration, and as you advance and get better equipment and vehicles the experience of gameplay qualitatively advances too which is satisfying.

As you go deeper and farther away you find so many beautiful alien biomes and terrifying creatures. The game provides equal parts wonder and terror.

slight spoiler warning

As you play longer, there is an incredible story that is ‘hidden’ within the game. To me it came as a surprise, like a great plot twist in a movie.

I tried to set up your (logging)service, but my project is an iOS app, so I can't complete the frontend setup.

Logs don't seem to go through, maybe because setting up a client is required to complete the setup?

For context, this project is a smallish backend(~10 endpoints) running on CF workers with a low volume of logs.

The goal for now is to get something basic working, since cf workers don't log by default and I need to track down a bug.

These assessments were made quickly, so they may not be accurate, but here they are anyway:

Logflare -

A js client library (https://github.com/Logflare/winston-logflare) has 2 high vulnerabilities, still uses commonjs imports in the example, last update 3 years ago. The latest tweet in the testimonials section of their home page is from 3 years ago. They were acquired a few years ago, so is the product just moldering? Or maybe they are just focusing on working with Supabase? In either case, not great for my case.

Log Push - I got this set up, but the logs were in a unknown binary format(or corrupt?). Even if is was working, the logs would be in R2, without great support for query/search/presentation etc. Not sure exactly what the problem is, but the feature feels a bit new/beta and the "upside" is kind of low.

Was just searching for something like this and considering rolling my own after a couple of strike outs(logflare and logpush/r2). Looking forward to giving it a try!

Love the graphic, mind sharing how you made it?