slapshot

There have been massive improvements in treatments in the last 5 years. Sure, cancer is far from being "cured" - but survival today is far better than 5 years ago for many forms.

Among many others:

- CAR T therapy going from lab to oncology suite (first launch 2017, but use rapidly growing)

- Approval of Keytruda and similar for many additional forms of cancer (see the 2021-2026 milestones here: https://www.drugs.com/history/keytruda.html )

- Liquid biopsy going from lab to PCP's office - starting with Grail Galleri and moving from there (yes, the NIH results were weak, but the idea of a liquid biopsy at all would be laughed off 10 years ago)

- Move of Atezolizumab and Tecentriq from infusion (hour) to injection (minutes) to increase availability

- Lower dose CT scanning for lung cancer, including for non-smokers

And a long line of immunotherapies that are making the leap from lab to chair right now.

The last 5 years have probably been the most exciting in cancer research since the launch of the monoclonal antibodies in the early 2010s. There is still incredibly far to go, but the trend is in the right direction: https://employercoverage.substack.com/p/decline-in-cancer-mo...

Radar is ineffective underwater because the radio waves are absorbed by the water. That is why there's no radar in use on submarines.

Sonar is not a valid solution here because it annoys the whales. Or at least high-power sonar, as used by the military, does. It would defeat the point.

Bay Area bias, sorry. Many airports near me did. I have no knowledge about Oklahoma.

No jets use or have ever used leaded products. Jets run on Jet-A, which is a close relative of kerosene. It has never been leaded. The purpose of lead was to prevent cylinders from prematurely detonating ("knocking") in internal combustion engines. Jets do not have any cylinders to knock; the fuel burns continually in an open combustion chamber.

You may have been thinking of 100LL (100 Low Lead) fuel for piston engined planes. Many airports stopped selling 100LL in January of 2022. The FAA has approved a lead-free replacement in fuels like UL94 that are steadily replacing 100LL.

Thanks for letting me know! I'll do that next time.

@dang

Super ageist and offensive. Also likely false. Bachelor's degree 2014: https://inside.tamuc.edu/academics/cvsyllabi/cv/MummJared.pd...

There's lots of room to nitpick the evidence, but the studies are published:

The relationship between age and job performance for Air Traffic Control Specialists (ATCSs) is an issue that has been revisited many times over the past few decades (Trites, 1961; Trites & Cobb, 1962; Cobb, 1968; VanDeventer & Baxter, 1984). Researchers have consistently found a negative relationship between controller age and performance across studies that have used different ATCS options (enroute, terminal), career stages (age at entry into training,current age on the job), and criterion measures (on-the-job ratings, academy performance) (Trites, 1961;Trites & Cobb, 1962; Cobb, 1968; VanDeventer & Baxter, 1984).

Via https://www.tc.faa.gov/its/worldpac/techrpt/AM99-18.pdf

After the pharmacies got sued for filling opiate prescriptions (which were written by abusive doctors, but the pharmacies are the ones who got sued)[1], is it any surprise that Xanax and Adderall are being limited? If pharmacies are at risk for filling prescriptions that are more complex than antibiotics, the end result is that they make it harder to fill them.

[1] https://www.fiercehealthcare.com/finance/federal-jury-holds-...

Commercial jets in the US run on Jet-A, which is lead-free and kerosene-like. Adding 737 flights will not add any lead.

You are thinking 100LL ("low lead") Avgas, which is gasoline-like and used for small propeller planes (think San Carlos airport, not SFO).

It's a general aviation problem, not a commercial aviation problem.

*(edited to swap San Carlos, not San Mateo)

The other way around. "Blank check companies" have existed for many many years, but were a relatively rare instrument and did very bespoke deals. Most investors never heard of them. In recent years, a standardized deal emerged that became known as a SPAC (and all the recent flavors of the month). If you look in SEC regulations, you'll see references to "blank check companies" all over the place.

Narcan is available "behind the counter" in most states. You have to ask for it, but a prescription isn't required.[1]

[1] https://www.cvs.com/content/prescription-drug-abuse/save-a-l...

My concern is not that AWS should be forced to host content they don't want. It's that AWS (and Apple, Facebook, and others) have misrepresented what they do.

It's no shock that DailyKos shouldn't have to host pro-Trump content. Nor should /theDonald have to host pro-Bernie content. We all agree that people can choose who to associate with, and that free association is important.

But AWS (and Facebook and others) didn't say "we're sites that present only one kind of content" the way /theDonald and DailyKos did. They presented themselves as universal tools for people to express themselves, build their own sites, install apps, etc.

So it comes as a shock when AWS says "we actually only want to support sites that present views that Jeff Bezos thinks are reasonable." And when Apple says "you can only download apps on your phone that we think do a good enough job moderating." And when Facebook bans people for posting wrong opinions.

The government can't and probably shouldn't force AWS to host content that Bezos doesn't agree with. It would be Amazon's right to host only content that is pro-Trump, or equally Amazon's right to only host content that is anti-Trump. But when Amazon presents something as a neutral utility but secretly enforces different rules, we can and should criticize them.

That's true even if all the content being removed today is garbage. I haven't seen any "worthwhile" content that's been affected by the recent moves, and I have never heard of any valuable speech on Parler. But I am still concerned that Apple gets to decide what apps I can install on my phone because they don't like the content. For every Apple (managed in California by socially liberal periople) there's a Walmart (managed in Arkansas by social conservatives) that will take the same powers and use them in a different way. Walmart is legally free to remove pro-BLM books from their online bookshelves, but we can and should criticize them if they do.

He asked questions on the first audio call, linked above.

That's not how subsistence farming is counted in GDP and poverty statistics. The value of home production is still counted. If you are eating only $2 worth of rice per day, you are counted as poor whether you buy it or grow it.

We (USA) fought a war over that. The "if we agreed to stay together then we have to stay together" side won.

In America, people would build their houses around an industrial zone and then complain about the industry -- this happens all the time. For some nuisances, like airports, it has broader impacts beyond just the industrial zone.

Yes. Spreading basins have become popular-ish in portions of California that have concentrated rainfall in the winter but high demand in the summer.[1]

[1] https://www.newsdeeply.com/water/community/2018/06/21/the-tw...

In academic literature about criminal law, "incapacitation" has the very specific meaning that somebody who is in jail is not able to commit crimes on the street. It has nothing to do with their health (even if they may suffer a health impact).

"The unwanted products could disqualify them from receiving a brace under Medicare if they need one in the future, prosecutors said."

I read an implied "if we hadn't caught the fraudsters" into that sentence.

As in "if we hadn't realized these braces were fraudulent, patients would have been denied braces they needed because they already reached the maximum number of annual braces covered by Medicare."

I currently own a house. I love owning my house.

But there have been long (decade+) stretches when I actively did not want to own. I was single, or I knew my family size would change and didn't want to buy a huge house, or I knew I would only be in the market for a few years.

The transaction costs of buying and selling each time would have been probably 5-10% of the total price of the house (broker fee, mortgage fees, inspections, etc). It simply would not have made sense to buy and sell a house every time I moved.

Having plenty of rentals available made it easy to move to where I needed to be, in a house size that made sense (neither too big nor small), in a cost-effective way.

The answer of "don't move so much" cuts income mobility. I moved to the SF Bay Area because it offered higher salaries. And it wouldn't solve the issue of family size changing.

(I haven't yet done the reverse -- which is to rent out the house I now own, but if I get a job offer somewhere else it'd be silly to force a sale to make it impossible for me to come back.)

Single stream recycling is largely solved. Unsurprisingly, humanoid form factors aren't optimized for conveyor flows of materials.

Lots of gates, air puffers, filters, size categorizers, etc. Maybe you could add an arm at the end, but there's no reason for the legs and torso of a humanoid robot.

Example: https://www.youtube.com/watch?v=ODu2kbpVSXg

The article says "pollution" not CO2. Given that they burn bunker fuel (very dirty oil left over after things like gasoline are refined away), it's likely the article means particulate or sulfur emissions.

The CO2 emissions are easily estimated and not even close. A container ship can burn 225 tons of bunker fuel per day at normal cruising speed.[1] At a generous 300 days in transit per year (they spend time in port loading / unloading / waiting), that's 67,500 tons of fuel per year. It's a massive number, but a drop in the bucket relative to the 913 million tons of oil consumed by Americans every year, the majority of which is spent on motor vehicle fuels.[2]

Even assigning just 50% of US oil consumption to cars, you're comparing about 450 million tons consumed by American drivers versus about 1 million tons for 15 large cargo ships.

[1] https://transportgeography.org/?page_id=5955 [2] https://www.statista.com/statistics/264825/oil-consumption-i...

Seatguru has extensive details on every plane and major carrier flight (down to which 777 variant and how recently remodeled).

The SEC only has authority to levy civil fines. They issue a fine, and then hand the case over to the US Attorney's Office (and often state attorney generals' offices), which then build a criminal case.

Stay tuned. This may not be over yet.

(A good comparison is the Fyre Festival, which led to both civil and criminal charges: https://www.cbsnews.com/news/fyre-festival-founder-billy-mcf... . )

Edit: Theranos was another where the SEC acted first, then the criminal case came next. https://www.vox.com/2018/6/15/17469332/theranos-elizabeth-ho...

Google "map of France." I see only one in the first 32 that includes French Guiana ("fully" French, use Euro, etc).

https://en.wikipedia.org/wiki/Master_mariner#United_States

or from gCaptain, which is linked elsewhere in the thread as a source of info on this particular incident:

http://gcaptain.com/mariner/

it will take years of sea time and weeks of classes to even get your Able Seaman (AB) or 100 ton master license. If you want 500/1600 ton mate or masters then even more years of sea time and months of classes. All of these requirements are outlined by the Coast Guard, but they change the rules all the time. You are never really done; every five years, when you come up for your license renewal, you will have to take some refresher courses. Sadly, none of this may be completed while you are at work, but rather while you are on your off time. It is expensive to take these classes and while sometimes your company will pay for the classes, room, and board, don’t count on it.

(edit:format)

In the U.S., rail freight volume appears to be going up and to the right, measuring both by distance-weight or just by total number of containers moved any distance: https://www.railserve.com/stats_records/freight_railroad_tra...

A few San Francisco companies seem to be doing this already: Grand Rounds, Amino, and to a much lesser extent Castlight. They sell through the employer-payer; not sure if they are competition for AmaMorganShire or potential vendors to them.

Much longer article: https://www.americanbanker.com/news/arisebank-raises-questio...