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rdruxn

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2. Glucose is transported in intestines via a glucose-sodium antiporter protein. Maybe we can find a drug that blocks this and you can eat as much sugar as you want! (Turns out you’ll have uncontrolled diarrhea if you do).

It's very cool! It's the SGLT protein. It's actually a sodium-glucose co-transporter and is why gatorade is so effective! It's the perfect mix of salt, sugar, and water to take advantage of that very protein (where salt goes, water follows).

And yes there is a drug that targets these - it's the SGLT inhibitors and they're very in vogue right now. Ozempic and Mounjaro are the two big ones in the news right now. They act on the SGLT I (found only in the kidney) so that you urinate more sugar. They don't act on the SGLT 2 (only found in the gut) but other medications in that class act on both.

But congratulations and alas! You nearly invented gatorade and a multi-billion dollar diabetes and weight-loss drug. Hardly bone-headed ideas.

But teams behave in an infinite combination of size, members, companies, and time

Slightly off topic, but I realize this is a subject I'd be interested in reading more about. Would be interested in suggestions in the same vein as Creativity, Inc. by Edwin Catmull?

macOS Big Sur 6 years ago

Same, yet Apple's System Status still has marked the software update issue as resolved

[dead] 7 years ago

Clickbait hyperbole and not news. Mods please remove this.

Doesn’t this negate a lot of the benefits of de-ICEing vehicles?

Sure some of the benefits, but the context is in the discussion of incentives and the attractiveness for the average buyer. 10km/day drivers have their needs sufficiently met with cheaper, shorter-range EVs.

If it’s accelerating along the longitudinal axis, then the slant doesn’t matter. It’ll never experience more than 1g orthogonal to the axis.

The problem is getting out of the thickness of the lower atmosphere. That’s why rockets go up before they go sideways.