For example, it would be interesting to incorporate Ghost Font into CAPTCHA systems, as most systems are easily solved by AI today.
It seems to me like it should be easy enough to take Ghost Font, apply normal video compression techniques, and analyze the compressed signal to recover the visual outline of the letters, which you would then analyze with OCR (or an AI I guess ...). In other words, a novel CAPTCHA technique but not necessarily "fundamentally more difficult" than existing CAPTCHA techniques, once the cat-and-mouse game gets going.