pombrand

Tl;dr amazon blocks acc for an accidental payment reversal, gives me no options to repay them and support can't help as the account is flagged. Halp

I credit Battlefield 1942 for helping me waste my time in highschool leaving me with bad grades and hollow experiences.

I hope she gets her own wikipedia page about this

Not a problem unique to America.

Average (Mean) Annual Death Rate per Million People from Mass Public Shootings (U.S., Canada, and Europe, 2009-2015):

Norway — 1.888

Serbia — 0.381

France — 0.347

Macedonia — 0.337

Albania — 0.206

Slovakia — 0.185

Switzerland — 0.142

Finland — 0.132

Belgium — 0.128

Czech Republic — 0.123

United States — 0.089

https://worldpopulationreview.com/country-rankings/mass-shoo...

4. Im aware but it still cumbersome, would be nice to do it without the using the keyboard.

5. Because I need more functionality.

Apple believes they always have the best way, and rarely gives you options to do things in other ways..sometimes they're right, but not always.

I switched from Windows last month, after installing rectangle, bettertouchtools and speeding up all animations possible, I'm left with the following gripes.

1. No magnetic windows the way windows does unless in the clunky fullscreen mode.

2. No way to turn off animations for maximising windows.

3. No way to let mouseover select window an action is taken in (i keep closing the wrong chrome window using mouse gestures)

4. Finder still sucks (so does no cutting and pasting files)

5. All apps cost money, e.g. ScreenX for windows is free and better than all paid macos options for screenshots.

6. Chrome window resizing seems artificially slow.

Overall windows still feels more productive, but also sucks more in many other ways, such as preinstalling candy crush or its opaque update system.

it actually looks great on the LG 5k giving you 2880 pixels across and there's no significant performance hit w a M1 macbook air.

Better yet, HP will re-enable auto firmware updates if you disabled them at lest with certain printers (they did for mine). HP never again.

Wider tires are still slower BEYOND A CERTAIN SPEED as drag increases. Furthermore tire rolling resistance test are done on a bumpy surface, and 25 mm tires > 28 mm.

That's literally a major reason why people buy Apple products, though. If you can't sideload things, there's literally no chance of your phone being compromised by those things.

False. People who don't want to take risk simply don't sideload, most people don't know how to anyways even on android - having the /option/ to do so is not a negative.

Android allows is and there's nearly no malware https://duo.com/decipher/google-data-shows-tiny-fraction-of-...

I think you're missing the point, the thing is that LSD gives you a new perspective on yourself, not necessarily that it just boosts the happy molecules in your brain.

Amazon's ads are 10x cheaper than Google/FB etc ads, that's why many brands remain amazon-only - they can't afford to advertise outside of it with their narrow margins.

Vitamin D is vital for adaptive immune system function too!

When a T-cell encounters a foreign pathogen, it extends a vitamin D receptor. A signaling device allowing it to bind to the active form of vitamin D. Only after this can T-cells perform their intended function. [1]

Which is likely why healthy levels > 40 ng/mL significantly reduce COVID mortality, there's been > 2 dozen obersvational studies and at least one randomized controlled one. [2]

1. von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C (April 2010). "Vitamin D controls T cell antigen receptor signaling and activation of human T cells". Nature Immunology. 11 (4): 344–49. https://doi.org/10.1038/ni.1851

2. Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R., & Quesada Gomez, J. M. (2020). "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study". The Journal of steroid biochemistry and molecular biology, 203, 105751. https://doi.org/10.1016/j.jsbmb.2020.105751

You can't even find aftermarket cartridges for HP's new printers like the Officejet 9020, and a set of OEM replacement ink costs $100.

They're also paranoid devices which re-enable auto updates by themselves, which is probably against EU law but hey :|

Guess the only option is keeping it off the internet completely.

Yes, basically all these low calorie entertainment activities release dopamine, giving you a constant high.

In other words you need to dopamine detox, sensitize yourself so you still feel rewarded from doing comparably "boring" activities!

I think there's something to be said for being a specialized generalist.

Being a true jack of all trades can mean you're mediocre at everything, it's better IMO to specialize on certain skills within different fields - ideally ones that synergize.

You are wrong, there's nothing indicating that PUFAs are as problematic as sugar or even problematic at all, on the contrary the evidence we have show they are beneficial.

It concerns me that your comment is the top voted, as it can lead to dangerous dietary extremism, say avoiding all PUFAs which are among other things implicated in helping the immune system "Paracrine interactions between adipose and lymphoid tissues are enhanced by diets rich in n-6 fatty acids and attentuated by fish oils. The latter improve immune function and body conformation in animals and people. The partitioning of adipose tissue in many depots, some specialised for local, paracrine interactions with other tissues, is a fundamental feature of mammals."https://pubmed.ncbi.nlm.nih.gov/15946832/

1. You shouldn't just throw in links to "support" your claims - to me this shows you don't understand what you're talking about, you should cite the relevant text otherwise it's just hand waiving.

The studies you cite are about radicals generated from PUFAs that are naturally a part of cell membranes, not from diet, and even goes against your claim by saying that PUFAs from diet help generate antioxidants that eliminate such radicals.

"Any change in the cell membrane structure activates lipoxygenases (LOX). LOX transform polyunsaturated fatty acids (PUFAs) to lipidhydroperoxide molecules (LOOHs)." i.e. cell membranes naturally have PUFAs."..."In order to remove LOO* radicals, plants and algae transform PUFAs to furan fatty acids, which are incorporated after consumption of vegetables into mammalian tissues where they act as excellent scavengers of LOO* and LO* radicals." - hey eating PUFAs help cells make radical scavengers. https://pubmed.ncbi.nlm.nih.gov/17914157/

2. Omega-3 is a polyunsaturated fats - yes they are less stable than SFAs, but that probably does not matter at all unless you're eating rancid oils. Polyunsaturated fats are not "extremely" reactive either whatever you mean by that.

Then we know that diets rich in PUFAs and MUFAs have positive effect on cholesterol ratios "We conclude that a mixed diet rich in monounsaturated fat was as effective as a diet rich in (n-6)polyunsaturated fat in lowering LDL cholesterol. " https://pubmed.ncbi.nlm.nih.gov/2761578/

This should really have the option to collapse the tabs in each group (only showing the colored dot or group name).

No it's not very hepatotoxic, on the contrary.

"Hydroxychloroquine has not been associated with significant serum enzyme elevations during therapy of rheumatologic diseases. Furthermore, clinically apparent liver injury from hydroxychloroquine is rare. " https://www.ncbi.nlm.nih.gov/books/NBK548738/

"Despite use for more than 50 years, chloroquine has rarely been linked to serum aminotransferase elevations or to clinically apparent acute liver injury."https://www.ncbi.nlm.nih.gov/books/NBK548224/

South Korea is at 0.6% CFR, the true IFR will be lower than this again due to false negatives and biased testing against symptomatic people.

South Korea will max end up with a IFR of 0.2-0.5%, 2 to 5 times worse than the flu.

If the control group still is positive for corona after 7 days in 90% of cases and we anticipate the intervention to get that number to 50%, with an alpha of 0.05 and a size of 24 in the intervention group, the study has a power of 0.957 and answers the question whether chloroquine stops viral shedding by day 7. This isn't cardiology where we need 50000 patients to find the significance.

Quercetin has an EC50 value of 84 uM in vitro against SARS-CoV, Chloroquine around 6 uM vs SARS-CoV-2 and it's a lot better absorbed - so to get any antiviral effect from quercetin you'd probably need at least 10 grams pr day.

Who cares about Case Fatality Rate (the % diagnosed that die), it depends on how many cases are measured. What you need to base yourself on is estimated Infected Fatality Rate (the % infected that die) which is what the CDC states is about 0.1% for the seasonal flu in the US. In Korea the CFR is closing on the IFR as they're testing thousands of asymptomatic people, currently at 0.6% AFAIK.

Infected Fatality Rate will likely end up at 0.3% taking the diamond princess cruise ship as a model (this assumes access to quality care and a PCR false negative rate of 29% adjusted for the higher average age on the cruise).

Worst case: 327 million people * 0.6 (a worst case nr) * 0.005 = 981 000 dead.

More likely 30% gets infected, we figure out what treatment options are optimal and we end up with something like 30% infected and a 0.2% IFR = 196 000 dead.

Airborne viral particle protection: N95 masks may only be effective used with eye protection. Surgical masks may not help at all.

Looked for interventional studies testing whether face masks and eye protection work in humans to protect against airborne viral particles. A critical issue with many such studies is that medical staff only use masks and/or eye protection at work, opening them to being infected outside of work.

Found a small study [1] getting around this problem by exposing subjects (n = 28, avg age 30.5 years) to monodispersed live attenuated influenza vaccine particles by placing them in front of a vibrating-orifice aerosol generator for 20 minutes, subsequently testing for infection using RT-PCR and culture in nasal washes.

Surgical mask: 3M 1818 | N95 mask: 3M 1860/1860S | Eye Protection: Z87 Uvex non-vented

-----------------------------------------------

RESULTS

-----------------------------------------------

No precautions: 4 out of 4 infected.

Ocular exposure only: 4 out of 4 infected.

Surgical mask only: 5 out of 5 infected.

Surgical mask + eye protection: 5 out of 5 infected.

N95 mask only: 3 out of 5 infected.

N95 mask + eye protection: 1 out of 5 infected.

1. Bischoff WE, Reid T, Russell GB, Peters TR. Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of n95 respirators, surgical masks, and eye protection in humans. J Infect Dis. 2011;204(2):193–199.

N95 masks may only be effective used with eye protection. Surgical masks may not help at all.

Looked for interventional studies testing whether face masks and eye protection work in humans to protect against airborne viral particles. A big issue with many such studies is that medical staff only use masks and/or eye protection at work, opening them to being infected outside of work.

Found a small study [1] getting around this problem by exposing subjects (n = 28, avg age 30.5 years) to monodispersed live attenuated influenza vaccine particles by placing them in front of a vibrating-orifice aerosol generator for 20 minutes, subsequently testing for infection using RT-PCR and culture in nasal washes.

RESULTS

- No precautions: 4 out of 4 infected.

- Ocular exposure only: 4 out of 4 infected.

- Surgical mask only (3M 1818): 5 out of 5 infected.

- Surgical mask with eye protection (Z87 Uvex non-vented): 5 out of 5 infected.

- N95 mask (3M 1860/1860S) only: 3 out of 5 infected.

- N95 mask with eye protection: 1 out of 5 infected.

1. Bischoff WE, Reid T, Russell GB, Peters TR. Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of n95 respirators, surgical masks, and eye protection in humans. J Infect Dis. 2011;204(2):193–199.

I.e 5x deadlier than the seasonal flu TODAY with an approx 0.1% mortality rate in the US, which has been decreasing steadily, so perhaps only 2-3x deadlier than the normal seasonal flu today on average.

"In 1918, doctors lacked intensive care units, respirators, antiviral agents, and antibiotics, an important fact in light of historical evidence of interactions between influenza and secondary bacterial respiratory pathogens (e.g., Haemophilus influenzae) as a significant cause of death during the pandemic." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374803/

It depends, there are several different form of inflammation. Curcumin seems to have little effect on muscle growth post exercise.

Shoe dog is a great book - about how you can afford to be a terrible business person if you have rich parents who bail you out and can live out of their garage. I don't see why people are so impressed by it? Nike shoes aren't even that good today.

How to mistreat your allies (Jeff Johnson)

How to mislead your suppliers and almost lose in court.

Do the marketing methods they used, which is perhaps the impressive part, even work today? Do you show up to track meets with shoes from an unknown brand? I don't think so. Do things that don't scale, but not the exact same things that worked decades ago.

Got my Paypal account and money frozen for shipping a product that was legal to sell in the US, but not online in the UK.

After asking around they told me the reason, and after implementing a system that stopped orders to the UK of said product they unfroze the account.

Yes they could have given me a warning and been more transparent, but overall not too mad.

Experience the same, have water fasted 5 days before and doing it twice a year. Three options here

1. Accept you will seemingly need less sleep and go to bed later, use any sleepless time in bed as an opportunity to read and meditate.

2. Be extra careful with sleep hygiene.

3. Use hot then ice cold showers before bed, and possibly sleep aids spanning from 1 mg melatonin to 7.5 mg doxylamine (very safe, but gives you a hangover due to long half-life, maybe not so bad if you feel too wired) to benzodiazepines or hypnotics like ambien (shorter half-lifes, more effective, ideally with assistance from a doctor).

Some argue that sleeping less is a good stress during a fast, but I haven't seen any good evidence to support that.