Funny, I just did an "Ask HN" about something similar yesterday and didn't receive any feedback [0].
I recently launched LetterPush, a basic email newsletter service [1]. I've been thinking of focusing on adding lots of developer features (robust API, webhooks, etc) to help automate marketing and transactional email processes.
I think that most businesses stop at MailChimp email blasts and "Welcome" emails on user sign up. Having a service that marries MailGun to your CRM/CMS tools would be absolutely brilliant (and quite profitable, I imagine).