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https://news.northwestern.edu/stories/2024/august/new-biomat...

The new biomaterial comprises two components: a bioactive peptide that binds to transforming growth factor beta-1 (TGFb-1) — an essential protein for cartilage growth and maintenance — and modified hyaluronic acid, a natural polysaccharide present in cartilage and the lubricating synovial fluid in joints.

and application:

the new material could be applied to joints during open-joint or arthroscopic surgeries. The current standard of care is microfracture surgery, during which surgeons create tiny fractures in the underlying bone to induce new cartilage growth.

modern MCP clients do smart tool search that obviates the entire "I am sending the full list of tools back and forth" mode of operation

How, "Dynamic Tool Discovery"? Has this been codified anywhere? I've only see somewhat hacky implementations of this idea

https://github.com/modelcontextprotocol/modelcontextprotocol...

Or are you talking about the pressure being on the client/harnesses as in,

https://platform.claude.com/docs/en/agents-and-tools/tool-us...

I picked up Tao Te Ching as an American teenager and was moved by how it cuts against the American faith in visible dominance and self-assertion, proposing a form of strength that is low, quiet, and unseen. It's much more than that of course, but that aspect had immediate impact on my thinking.

Backing up Spotify 7 months ago

Please note that Apple Music and iTunes Music data will be migrating away from the Enterprise Partner Feed (EPF). Starting July 16, 2024

Telling the Bees 1 year ago

Had a hard time parsing this, assumed "breeder" was the role of a human ranch hand, and you were telling them about family trivialities ("bull") so they felt included and soothed. Theory really fell apart around the time you started giving them corn and "sweet feed".

The eternal red flag of a DB UI that tries to support wildly different backends explains a lot of the problems. Many sane and powerful Postgres features can't be used because Directus also needs to support SQLite, for example. Views not properly supported, search features inadequate, graphql DSL with arbitrary limitations, a lot of weird or dysfunctional relational patterns when something much simpler would do... it's a parallel, inferior system on top of stock pg that is very frustrating when used at some depth.

The Syntilay company used Midjourney AI to create the basic shape of the shoe, after which an artist drew a sketch based on Midjourney's creation. That image was run back through Vizcom AI to produce a 3D computer model. After that model was created, generative AI was used to apply the patterns to the model, to give it some character.

I assumed this was going to be a functional evolutionary algorithm to make an efficient shape, it's just an image generator and an artist in the loop

Yeah word replacement is exhausting, and it does feel like the two fluent states for me are extreme relaxation and a very specific amount of localized stress. Lots of... unnatural pauses. Sometimes warmup sounds like "uhhh" that can inject a kind of vowel before a word. Have you tried listening to an AI version of yourself speaking fluently? I have and sent it to some friends – one of their points of feedback was that the cadence isn't like mine. My cadence is built around stuttering avoidance!

Fun!

The 11labs agent product is promising but very buggy, I was glad to see some of those issues in your implementation as well. The agent often drops out and comes back randomly after long stretches of silence. They also seem to be running some kind of half-functional censor on the llm output when used with Gemini 1.5. It also bills 500 credits for any time < 1 minute, not the aggregate use.

Reminds me of the DMT "machine elves" that appear in hallucinations to westerners that have been exposed to those ideas, whereas indigenous ayahuasca experiences tended to materialize more naturalistic visions like animal spirits, etc.

WP21 2 years ago

It sure seems that way until you need to get just a little bit deeper and you realize what a dumpster fire WordPress is.

You want metadata on posts, you install ACF. You want to filter on that metadata, good luck if it's over a couple filters simultaneously, the SQL queries will time out. Take a look at WP's insane schema to figure that one out.

Gutenberg promises to have WYSIWYG editable React components, which is a big deal, but they made insane decisions like storing the attributes in HTML, rendering HTML in the database, and requiring component developers to keep an array of deprecated changes when they want to modify anything on the component.

There are some people trying to untangle Wordpress by refactoring and bolting Laravel onto it[1], but every layer is just a nightmare; the authors of different parts can barely assess why things randomly break.

You might find WP appealing for the plugin ecosystem, but the plugins are completely random in implementation, so you're likely to get a bloated scramble of CSS and JS pushed to your users.

I moved to Directus and Astro, but I would probably use a Laravel-based CMS like October or Statamic for more generalized PHP deployment.

[1] https://roots.io/

some countering that it might just be the practice of drinking a very hot infusion

Yeah and from what I remember, frequently cited studies were looking at the combination of maté with tobacco and alcohol, others didn't control for the delivery style. Maté, especially when consumed in a tiny gourd that's constantly refreshed with boiling water, can make the tissues in your mouth and neck more vulnerable to subsequent cigarettes.

On top of that, maté leaves are often smoke dried, which carries some self-evident risks. My conclusion was to get air dried leaves and be mindful of how hot the water is.