HN user
Yes, exciting stuff.
Not to mention the gene-therapy version of the same PCSK9 inhibition pathway called VERVE-102 which Eli Lilly is putting through human trials as we speak.
I imagine that stacking the LP(a) antisense therapy with a PCSK9 inhibitor, and/or a statin or Nexlizet would probably lower odds of heart disease death by two to three orders of magnitude. But I guess there isn't solid mortality data to say for sure.
For context, that revenue was $18.67 billion in 2025, with a net loss of $4.94 billion.
And we must remember that 6G is in the final stages of development, which has peak speeds of 1 Tbps.
Just because someone has a high net worth does not mean they are not trying to scam people, and it is good to be on the lookout for that.
Every human being is self-interested, at least to some degree. So, it is perfectly expected that he seeks money, fame, status, power, sex, etc.
But he doesn't seem to exhibit these to an abnormal degree, and in any event, you can just evaluate his claims based on evidence and logic and they either succeed or fail.
Just because the Wright Brothers were selling airplanes doesn't mean that they didn't fly.
That was true up until generative AI. Now, we have a new problem of high-definition fakes being easy to produce.
Look up the lifestyle of Hugo Chavez's daughter, or the family of Tareck El Aissami, or the Narconephews affair, or the Cartel of the Suns.
nice, I was just thinking that they needed a very slow database.
A lot of founders are the cause of enshittification. In fact, most of the big names I can think of are.
open hardware to me means that you have access to all of the specifications for building the hardware. Things like when the laptop company Framework posts github repos full of CAD models. Or, initiatives like RISC V.
And, alongside that, there's also open firmware.
Unlocked hardware is maybe what I would call hardware that enables swapping out the software. Although, historically, we didn't even need a term for that, because that was the default aside from outliers like Apple.
The panopticon concept from Bentham was interesting because even if there was only a small chance that you might be observed, at any given time, then people would act as if they were being observed. Even if they weren't.
We have had that kind of system, now, for just about everything. Not just from the Big Brother direction, but also the Little Brother direction. At any time, a mob of people might decide to pull up your old digital footprint and condemn you for it.
Likewise, even before AI, at any time the IRS could decide to audit your past tax filings, or data breaches could expose your personal secrets, or street camera can nab you for a traffic violation, or someone could decide to pull up surveillance footage and get you for something, and so on.
The exact degree of difference between the two systems is significant, but much of the marginal psychological burden of such things has already been paid by everyone living in industrial civilization. And, as with the panopticon, just the small chances of active monitoring already provided 80% of the sought-after result.
Indeed, that kind of condition is what people like Ted Kaczynski were so bothered by decades ago.
Those living in the epicenters of civilization, like those in the largest cities, have basically been under almost constant surveillance now for decades.
yea, but those users can still upgrade to 6.7 which isn't even out yet, and then also remain on that as a supported release for a significant amount of time.
And you'd have to balance all this against the wealth of severe X security bugs that have been coming out even just this week, and the maintenance burden of supporting it in a volunteer project with limited backing.
There's an argument that they are being too conservative. Other DEs like GNOME have already dropped X.
It is the standard, and is extremely flexible. It was probably the wrong framework for most use-cases, which are often just CRUD screens. But, we are in an AI world now, so probably Javascript in general and even Typescript is starting to become the wrong move. Programming languages and frameworks which offer a ton of guarantees is what you need, now. In my humble opinion.
Is he talking about github?
So, the problem is that he feels strongly about not incentivizing what he considers sexual exploitation. If he had the reverse position, then suddenly you would feel more positively about his identity group?
Prop 13 is clearly the most distortionary issue, of all. Until that is overturned, you are stuck with constrained growth.
Maybe that's why they hired first, and then fired.
Give the new people 6 months to benefit from all that institutional knowledge.
My understanding is that inference (running existing models) is around 1/4th of the average compute budget for AI companies. Training new models takes up about 3/4ths.
As such, using only 11% of their GPUs indicates that they've elected not to do as much training as they are capable of.
Operation Desert Storm was only 43 days long. Epic Fury is most of the way there.
Is there any danger of transplanting organs into you that have genes which signal not to develop a brain? Would those genes potentially affect your actual brain?
The site specifically says it is swipe-friendly, and the GitHub site makes clear that it supports autocorrect.
See also: meme stock
TSLA market cap is 1.29 trillion today.
Of course, with a P/E ratio of over 381
Would be interesting to know whether theacrine or paraxanthine can provide the same neuroprotection without as much downsides.
That was the point. Look up Goodhart's Law
Good article. The entirety of the "epidemic" is explained by:
- Expanding diagnostic criteria for an illness with no mechanistic explanation
- Increasing access to mental healthcare
- Overmedicalization of traits that aren't causing actual dysfunction, driven by cultural changes in parenting
- Rampant non-reproducibility and pseudoscience in the field of psychology
- Weird online trends of self-diagnosis where mental illness provides clout
- Anti-vaccine paranoia trying to find some kind of mysterious epidemic to pin on vaccines
Of course, a war on authentic neurotoxins is warranted even if autism rates are declining. But only in a manner informed by science and sober cost/benefit analysis.
Seemed potentially like a new kernel, rather than a new OS, and thus potentially a replacement for the Android kernel one day.
But that would mean all of the Android SDKs would need to be abstracted away from Linux, but it seems like they abandoned some of that effort and are mostly just emulating Android on Fuschia for now.
NFTs have been extremely intertwined with money laundering. The more legitimate and interesting the original NFT, the more plausible the fictitious asset inflation will seem. The extent to which such a thing involves the actual participation of the artist probably varies.
Complex behavior between interconnected systems, out of the purview of the formal language (OS + database + network + developer + VM + browser + user + web server)
Isn't this what TLA+ was meant to deal with?
It's hard to argue that's a bad thing unless you're a property owner who's upset their house didn't appreciate 20% in 5 years.
I want money for nothin', and chicks for free
After governors in southern states sent migrants north, support for immigration evaporated, just in time for election season. Causing swings of like +20 for Trump in staunch blue states like NJ and IL. If that study were accurate, then those stunts should have resulted in an increase in support for immigration.
You have profoundly misdiagnosed my mindset, so perhaps don't make psychoanalysis your day job.