notsosmart

Wow, a heart breaking read for sure. There is a gofundme for Jake here -https://www.gofundme.com/f/help-the-fight-against-cancer-wit...

I agree Dr. Bredesen's protocol probably can't hurt as it advocates a healthy lifestyle and diet, but there is NO evidence that it can prevent or reverse Alzheimers[1], as he claims. Also, Dr. Bredesen charges $1800+ for the protocol[2] in addition to selling branded supplements.

1 - https://www.ucsf.edu/news/2020/05/417431/pricey-protocol-not... 2 - https://www.healthleadersmedia.com/clinical-care/alzheimers-...

For readability: https://outline.com/UAcT6s

Here is a more readable version https://hbr.org/1996/11/inside-intel

In fact, we now have compelling epidemiological evidence that vaping almost doubles risk of cardiac events [1].

Somewhat misleading since more than half of those studied were smoking and vaping. From the study:

Among the 9,352 current and former e-cigarette users, 333 (3.6 percent) had experienced a heart attack at some point, with the highest percentage (6.1 percent) among those who used e-cigarettes daily. In the analysis, a quarter of the 2,259 people who currently used e-cigarettes were former smokers of conventional cigarettes and about 66 percent of current e-cigarette users were also current cigarette smokers.

This might not be true... http://www.health.com/sleep/sleeping-in-weekend

"pacific" also means "Peaceful in character or intent."

When apoptosis fails, it's might be because p53 binds to foxo4 and gets stuck in the nucleus which prevents the p53 from getting to the mitochondria. In the experiment p53 in the paper, p53 unbound from foxo4 in the nuclease and bound to foxo4-dri and successfully flowed down the mitochondria so apoptosis could occur.

No, it's about things we can't change: "What we want to get rid of in February is venting about things we can’t change."

It is really sad that instead of discussing the merit of his argument, we are debating the quality of OP's site.

It is ridiculous that I have to police my site for low quality inbound links or risk getting banned (even more so for mom and pop webmasters who are more susceptible to link penalties). Lastly, if you are penalized, try recovering unless you are big brand like Overstock or JCPenney with millions per year in Adwords spend.

Darren contact me. I might be able to help sales / seo wise.

I might be interested. Can you please email me basic revenue and traffic data?

Not surprised, but they have 65% share of search in the US, so it's a disturbing trend for high quality sites ranking organically.

How condescending... even by hacker news standards.

Spiegelhalter's TED talk about this subject is quite good.

http://www.youtube.com/watch?feature=player_embedded&v=4...

So aside from K&R, what are some of the best small books?

Good article. What would be an example of premature scaling in a startup? Too many hires?

I really enjoyed this article. I wish she had given specific tips on how to think more creatively. She mentioned what happens "when" you think creatively, but did not really go into the "how."

I'm just learning ROR from an online tutorial (http://railstutorial.org/), and I wish I had this last week. For newbies like myself, I think installing the framework is sometimes such a big hurdle, it pushes one to give up early. Which is unfortunate, because I read the real challenges happen a few weeks in.

I had a weird issue where I had to reinstall xcode from the OS X DVD. Took a bit of Googling to figure that one out.

Wunderlist is actually available for both Mac & Windows now.

Would eating fruit along with a cup of coffee be a good way to replicate? Or would the there not be enough of a spike in sugar to get the same result?

Yes, but this one was related to the effects of glucose combined with caffeine.

I thought there might be some value in knowing that a study confirms it.

The bottom line is that if you work hard enough you can compensate somewhat for lack of talent. You probably won't be the next Mozart or Einstein of your field, but the good news is that you don't have to be inorder to be very successful.