noleary

There've been some interesting new developments in cell therapies over the last few years. Bemdaneprocel from BlueRock Therapeutics is now into Phase 3 trials for Parkinson's, for example. The essential idea is to implant some dopaminergic neuron precursors to grow new cells in place of cell death. Still a long way from the kind of general stroke treatment you're describing, but regenerative neuroscience is looking pretty promising.

---

[1] https://www.bluerocktx.com/bluerock-therapeutics-announces-p...

Also linking here the creator's broader portfolio: https://www.baothiento.com/

Seems to be changing the .org to a .com

https://firestriker.org/blog/building-firestriker-why-im-mak...

--

related, author is a friend with a less active HN account https://news.ycombinator.com/user?id=blakeofwilliam

If you build apps with a lot of traffic, you know the first thing to break is the database.

Just out of curiosity, what kinds of high-traffic apps have been most interested in using PgDog? I see you guys have Coinbase and Ramp logos on your homepage -- seems like fintech is a fit?

FYI, Tungsten prices are quoted in metric ton units (MTUs) [1], which surprisingly aren't metric tons. They're actually 1% of a metric ton -- or 10kg. [2] So the price of Tungsten is actually 100x that.

[1] https://www.fastmarkets.com/metals-and-mining/minor-metals/t...

[2] https://quoteddata.com/glossary/mtu/

I'm not smart enough to stake an opinion on the viability of fusion. I pretty much only have high school mechanics and Wikipedia in my toolkit.

I can only ever make material conditional claims about things like this :)

Hey, I wrote the article. This is my personal website that I wrote mostly over the weekend.

I went down a rabbit hole reading about metals and mining and just thought it was interesting. Not an expert or a nefarious actor, unfortunately.

Reserves means something specific in the context of minerals! Reserves measure 'economically viable' deposits. [1]

There used to be tons of tungsten mines in the USA, e.g. in Colorado linked below.

[1] https://resourcecapitalfunds.com/insights/rcf-partners-blog/...

[2] https://coloradogeologicalsurvey.org/publications/tungsten-m...

https://archive.md/zqPZA

We responsibly disclosed this vulnerability to Notion via HackerOne. Unfortunately, they said “we're closing this finding as `Not Applicable`”.

Related: https://news.ycombinator.com/item?id=46527706

It's not that uncommon to keep the "CTO" title and not be the primary manager of the engineering organization. There are all kinds of things you can do with the org chart. If I recall correctly, Clickhouse works this way.

The company's cofounders comprise three people [1]:

* Aaron, a sales-oriented CEO from Elastic and Salesforce

* Alexey, the original Clickhouse developer, as CTO

* Yury, an experienced engineering executive from Google/Netflix as "President"

An excerpt from the launch announcement [2]:

While negotiations were still ongoing, Katz decided they needed a third co-founder. “I kept thinking, if I could get a third co-founder to run product and engineering, and if I could find someone with the same level of experience building distributed systems on open-source that I have on go-to-market, it could be a really compelling combination,” Katz says.

---

---

[1] https://clickhouse.com/company/our-story

[2] https://www.indexventures.com/perspectives/the-fast-and-the-...

Ontario Teachers' is a pretty active principal in venture/growth financings and a major LP to a bunch of funds. That said, venture/growth is a pretty small percentage of their holdings.

---

[1] https://www.crunchbase.com/organization/ontario-teachers-pen...

[2] https://www.otpp.com/en-ca/investments/our-investments/teach...

Imagine two different password strength standards:

1. Just a 4 digit numeric PIN like `1981`

2. A 20 character upper/lower/numeric/special-character password like `qmd1tkf7mwa.PQB0qrz$`

--

The PIN has lower entropy and is therefore a lot easier to brute force.

I haven't calculated this stuff myself -- I just used Wolfram Alpha -- but it looks like the PIN would take <1 second to brute force, while the 20 character password would take 7.6 * 10^25 years. [1] [2]

--

[1] https://www.wolframalpha.com/input?i=password+strength+qmd1t...

[2] https://www.wolframalpha.com/input?i=password+strength+1981

It seems to lean more into transactional email than being a 1:1 Substack clone, but I have heard good things about Dittofeed [1]. It's pretty self-hosting friendly, all things considered. [2]

We went with Substack basically because it's really easy to newsletters live on as webpages, but if you're going through the trouble to self host and build a website anyway, Dittofeed might be a good fit.

--

[1] https://www.dittofeed.com/

[2] https://docs.dittofeed.com/deployment/self-hosted

There’s a practicality to having well-made shoes that you can repair — and there’s also romance and nostalgia ... Doing this work affects how you see the world. You become sensitive to art and beauty. You develop a sense of history, time and place. I’ll notice things other people might not notice, like the patina of an older building that’s a little bit worn. I’m drawn to these older buildings that bring in a nostalgia of time, place and character, just like a good pair of shoes can.

Interesting excerpt:

Co-author Professor Christoph Salzmann, of UCL Chemistry, said: “Ice on Earth is a cosmological curiosity due to our warm temperatures. You can see its ordered nature in the symmetry of a snowflake.

“Ice in the rest of the Universe has long been considered a snapshot of liquid water – that is, a disordered arrangement fixed in place. Our findings show this is not entirely true.

“Our results also raise questions about amorphous materials in general. These materials have important uses in much advanced technology. For instance, glass fibers that transport data long distances need to be amorphous, or disordered, for their function. If they do contain tiny crystals and we can remove them, this will improve their performance.”

I love that this was a "stress-relief project."

(I am a cofounder of Tesseral)

Honestly, I'm not intimately familiar with Zitadel's solution. At a quick glance, it seems quite powerful! But it does seem like our product is more opinionated -- and is more narrowly focused on serving B2B applications.

I suspect that if you have the appetite and experience to build something unusual or otherwise complex, Zitadel will be a great fit. Perhaps they are like Keycloak in this respect. On the other hand, we try very hard to steer developers into a 'pit of success' by abstracting away a lot of details that most people don't need to worry about.

But I'll admit that comparison may be inaccurate; I probably will have to look in more detail. (The comparison will certainly seem wrong months / years into the future as our companies evolve!).

(I'm a cofounder of Tesseral)

We're huge fans of Better Auth -- it's a really great offering. They might have their own take on how we differ, but here's my best attempt at a quick comparison.

We take pretty different approaches to roughly the same family of problems.

Better Auth is focused on being a great library for TypeScript. If you write Typescript and want to build your own auth, they're a great bet.

We're more of an API-first service that's agnostic to the language or framework that you use. We have a pretty opinionated product that is meant to handle auth for you -- it's not really an auth library per se.

oops, thanks for flagging. we'll fix this! we only recently did a complete overhaul of our website and are still patching up some details

oh cool! I want to try this soon.

I can't wait to try this! I studied a few languages in school and have lost any semblance of proficiency -- mainly because I never have a real occasion to use anything other than English. I've been waiting for someone to build something like this

The integration of generative AI with computational protein science has revolutionized protein design while also posing dual-use risks, such as enabling the creation of pandemic-capable proteins that require strong biosecurity safeguards. Here, we introduce FoldMark, a first-of-its-kind watermarking strategy leveraging distributional and evolutionary principles tailored for protein generative models, balancing watermark capacity and structural quality.

Relatedly, the first footage of the colossal squid captured by the same remotely operated vehicle: https://www.youtube.com/watch?v=lzPoG9H8Hlo&t=12s

(I wrote the article)

I probably could have phrased that better.

I often meet people who think their customer asking for SCIM provisioning means that their customer is identically asking for some newfangled data retention policy. All I meant to emphasize was that SCIM is just a provisioning / update protocol.

Indeed, you are right -- we see customers careful about the data retention policies applicable to SCIM data -- but that's because they'll have reasons to be broadly concerned with data retention matters. Hence my writing "this is usually a separate conversation you might need to have with your customer."

You mentioned your early customer in obesity medicine.

Are there specific kinds of clinics that are an especially good fit for you? Are you seeing any patterns in the kinds of clinics that are relatively eager to adopt an AI product like yours?

I don't have any feedback on what you're up to, I just think it's interesting!

ha! I'm glad to hear

(I wrote the article)

I genuinely didn't mean it to be much of an ad for our company. I was just surprised how few people had written a simple explainer of reasonable quality.

no I just meant the google drive link :)

it says 'access denied' for me