HN user
Scientist. Chemistry and Nano/Materials
I was aggressively recruited for education as a math undergrad.
Was it because you were male or because you were studying math? Many schools struggle to find good math teachers; it's one of the qualifications in perpetual shortage.
Suggestion: Require a user to hit ENTER or SPACE to clear the word, even if it's a wrong word. Being able to see the letters laid linearly is useful to solving. Automated clearing of wrong words is unhelpful.
I have never, ever – not even once – seen a graphical abstract that usefully “summarized the contents of an article”.
The author has never worked in chemistry. They are absolutely ubiquitous in scholarly journals for chemistry and I'd say that most people trained in chemistry often only read the graphical abstract when initially deciding whether the paper is worth a deeper read. Perhaps chemistry is a naturally visual field, given that we rely on visualizations of reactions and mechanisms from the very start of our university education.
The table of contents (TOC) graphic usually shows a key chemical structure (thus bonding connectivity, angles, elements, and electronic configurations), reaction mechanisms or conditions, models, or even core results as graphs. Now I do not claim to understand what is implied in every TOC graphic, however I can immediately see which branches of chemistry the article relates to faster than I can process the title, especially in a multidisciplinary chemistry journal.
That ability to categorize to identify relevance is a bigger issue in reading a multidisciplinary chemistry journal like the Journal of the American Chemical Society:
https://pubs.acs.org/toc/jacsat/current
But graphical abstracts are still immensely useful within a subdiscipline such as organic chemistry, which I suspect were the early adopters of TOC graphics:
https://pubs.acs.org/toc/joceah/current
The better graphical abstracts tend towards simplicity, but it's a challenging task to distill a year or more of research into a single picture. And, unfortunately, graphic design is not a subject for which scientists generally receive additional training, despite it being a core element of digital communication.
A Bonferroni correction would be suitable. I usually see it used in genome-wide association studies (GWAS) that check to see if a trait or phenotype is influenced by any single nucleotide polymorphisms (SNPs) in a genome. So it's doing multiple testing on a scale of ~1 million.
One of the simplest approaches to correct for multiple testing is the Bonferroni correction. The Bonferroni correction adjusts the alpha value from α = 0.05 to α = (0.05/k) where k is the number of statistical tests conducted. For a typical GWAS using 500,000 SNPs, statistical significance of a SNP association would be set at 1e-7. This correction is the most conservative, as it assumes that each association test of the 500,000 is independent of all other tests – an assumption that is generally untrue due to linkage disequilibrium among GWAS markers.
https://journals.plos.org/ploscompbiol/article?id=10.1371/jo...
One persistent problem is that there isn't a Canadian English spelling option in most software with spellchecking functionality. Often we are forced to choose between US English and British English spelling defaults, when neither is quite right. I suspect that this was a stylistic choice not of Carney himself, but whoever proofread the document. There has been considerable erosion in Canadian orthography in of late, which has only been made worse with the widespread adoption of UFLI English language learning materials in our schools' elementary curricula, which emphasizes American spelling and pronunciation.
Paper: https://doi.org/10.1073/pnas.2517473122 (Open Access)
Not to cast shade, but it looks like you've essentially built a front-end for Desmos. It definitely makes things faster than trying to do it directly in Desmos.
Suggestion: Most of the fits that you've done assume that the errors are normally distributed. It would be worthwhile adding some graphical or numerical checks on that, rather than having goodness of fit or visual inspection be the only indication if this is a faulty assumption.
It gave made for a good quick check testing some data I had.
Copy-paste worked perfectly for me. I just copied 16 data points I had in an open G Sheets tab and used the "Batch Add" button.
LaTeX was much easier with Overleaf for my PhD thesis. I still recommend that for friends starting a thesis or a book project. I even used it for recent book project with a friend.
As you noted, one needs a lot of fine tuning to meet publication rules & guidelines. Compared to a local LaTeX editor or Overleaf, this looks too generic to meet the needs I've had in the past. Sure, LaTeX can require a lot of tinkering, but PhD students ought be able to figure it out for themselves, whether through documentation, forums, or asking labmates.
Two articles that I found offered a well-rounded analysis:
- https://www.engadget.com/big-tech/youtube-may-reinstate-chan...
- https://arstechnica.com/gadgets/2025/09/youtube-will-restore...
It's what their lawyers are advising them.
The Globe and Mail had a piece on March 25th on the advice that lawyers were giving to their clients, often Canadians working on TN visas down south:
York-based immigration law firm Dyer Harris LLP, which helps foreigners secure work visas in the U.S., sent an e-mail to their clients residing and working in the country to hold off on international travel altogether, unless in an emergency.
Lawyers advise Canadians working in U.S. to avoid travel amid border crackdown, The Globe and Mail, 2025-03-25. https://web.archive.org/web/20250325223021/https://www.thegl...
UV damage to internal tissues seems unlikely given that the tartrazine dye they used absorbs strongly in the UV region of the spectrum. You can see this in Figure S1 A & B:
https://www.science.org/doi/suppl/10.1126/science.adm6869/su...
Also the abstract of the article notes that strong UV absorption is likely a prerequisite for this effect:
We hypothesized that strongly absorbing molecules can achieve optical transparency in live biological tissues. By applying the Lorentz oscillator model for the dielectric properties of tissue components and absorbing molecules, we predicted that dye molecules with sharp absorption resonances in the near-ultraviolet spectrum (300 to 400 nm) and blue region of the visible spectrum (400 to 500 nm) are effective in raising the real part of the refractive index of the aqueous medium at longer wavelengths when dissolved in water, which is in agreement with the Kramers-Kronig relations. As a result, water-soluble dyes can effectively reduce the RI contrast between water and lipids, leading to optical transparency of live biological tissues.
https://www.science.org/doi/10.1126/science.adm6869
However this kind of research into the effects of absorption bands on the transmission properties at interfaces might ultimately bring about more effective sunscreen formulations.
You cannot always obtain a generic version; sometimes not even the original version.
Drug manufacturers regularly take approved medicines, which are off-patent and non-exclusive, due to safety reasons (side-effects, risks to patients) or due to commercial reasons: high cost of production, low demand, or possibly to increase demand for an exclusive alternative.
The FDA maintains a list of "List of Off-Patent, Off-Exclusivity Drugs without an Approved Generic": https://www.fda.gov/drugs/abbreviated-new-drug-application-a...
See also: https://en.wikipedia.org/wiki/List_of_withdrawn_drugs
There are also perverse incentives at play and it often isn't easy to get a generic approved, especially if the original drug was already removed from market, under biosimilar regulations:
https://prospect.org/health/2024-03-14-novo-nordisk-disconti...
With this, there are no changes to our support policy for existing Chromecast devices, with continued software and security updates to the latest devices.
"no changes to our support policy" links to https://safety.google/nest/
It bothers me when these company blogs link to the wrong page for finding the aforementioned policy. It feels so deceptive. I've seen it happen multiple times. Is it intentional?
Japan Institute of Heterocyclic Chemistry, the publisher of the journal Heterocycles (1973-2023) [0] is suing CLOCKSS, after its content was released on June 25, 2024 [1]. All of the content from Heterocycles had ceased being available online, and per their agreement with CLOCKSS Archive in 2011,[2] all of the journal's 106 volumes have been made available under the CC BY-NC-ND 4.0 license.[3]
For how this works, see "How CLOCKSS Works" [4] & "How LOCKSS Works" [5].
Chemistry World also had an earlier article ("A key chemistry journal disappeared from the web. Others are at risk", 2024-04-09 [6]) discussing the journal's sudden disappearance [7] and the loss of access when it went offline, an increasingly common problem with scholarly research.
[0] https://en.wikipedia.org/wiki/Heterocycles_(journal)
[1] https://clockss.org/clockss-triggers-heterocycles/
[2] https://clockss.org/the-japan-institute-of-heterocyclic-chem...
[3] https://clockss.org/triggered-content/heterocycles/
[4] https://clockss.org/about/how-clockss-works/
[5] https://www.lockss.org/use-lockss/how-lockss-works
[6] https://www.chemistryworld.com/news/a-key-chemistry-journal-...
[7] https://web.archive.org/web/20240217181955/https:/www.hetero...
You claim, as a "fact", that someone who wrote this [0], identifies as Jewish?
in a malpractice situation, a physician could be liable if they made diagnosis or treatment decisions based on unverifiable LDTs.
That seems to be a senseless concern, since offered the evidence of a lab test, a physician should be prompted to investigate further. No physician (nor individual) should ever be making a diagnosis or treatment decision based on a single line of evidence.
More importantly, such results can help offer hard evidence to pressure one's physician to investigate a particular complaint, which can be difficult to convey or to convince the physician it's real. Physicians are often dismissive of things that they do not understand, or of certain classes of patients. Consequently many patients are forced to figure out the source of the problem for themselves.
With a lab based test result, you can go to a physician and say, "Hey, this isn't just my imagination nor some kind of over-reaction. It's tangible and externally verifiable."
And for those without a GP, waitlisted like myself (5+ years waiting here in Canada!), such tests can help one navigate our piecemeal medical system more effectively.
The Dungeon Crawler Carl series' first 4 or 5 books (it's been a little while) were excellent. Carl's tone reminds me of a detective novel, while the setting is more reminiscent of Ready Player One and The Matrix. The genre is a LitRPG novel (admittedly a genre I'd never known existed until reading DCC), heavily doused with comedic elements. Lots of mature themes and references to sex, drugs, politics, and violence, but with some of the allegorical or illustrative critique (to the point of absurdity) you'd find with Douglas Adams or Terry Pratchett when discussing serious topics with parallels to real life, in an imagined scifi/fantasy setting. I'd recommend the series if for those who haven't picked up a book in a while and who would appreciate those elements.
Fun game, although it would be helpful to have the "How to Play" instructions ( https://huewords.snellman.net/help.html ) explicitly state that shorter letter sequences (2,3,4 letters) do not need to form words. That's an expectation built up from many other crossword games, so it would be good to nullify it through a clear statement that the usual crossword rules do not apply here.
I remembering visiting WBB at 20 Edward St when I lived in the GTA during a co-op term. But the real treasures I found were usually in BMV Books next door at 10 Edward St. BMV offered incredible collection of vintage books and magazines. I recall the owner guaranteeing to me that he could find any book sold at WBB and get it to me cheaper. Glad to see that it's still standing.
a non trivial expense that's hard to entice enough users to cough up money for to make viable
Yet the site's operators got rid of one of the most popular mechs for monetization: Awards.
Throw in the Oxford comma and George has become a policeman: “Through the window she saw George, a policeman, and several onlookers”.
The problem here might also be that of artificially limiting the solution to commas. We have alternative or better punctuation available to demarcate the interrupting thought. One could emphasize the relationship better either with an em dash or with parentheses:
“Through the window she saw George — a policeman — and several onlookers.”
“Through the window she saw George (a policeman) and several onlookers.”
In text either of those could better express the different emphasis which verbally would be conveyed by a shift in the speaker's tone.
Everything noted by awjlogan is correct in my experience. To add to the question of incentive, Organic Syntheses is a non-profit corporation since its inception. It's worth reading the organization's history page:
https://www.orgsyn.org/history.aspx
Regarding compensation, the model employed for reproduction of experiments is that students associated with the Board of Editors are paid to carry out the checking process:
Junior checkers (students associated with members of the Board of Editors) now receive an honorarium for their efforts. This change recognizes the more complex and sophisticated procedures that now appear in these volumes. Also, because of the greatly increased cost of chemicals involved in the checking process, checking editors are now reimbursed for their costs; it is no longer reasonable to expect their own departments to absorb these expenses.
The incentives here are so different from a typical chemistry journal in part because Organic Syntheses is not engaging in a race to publish as many articles as possible, nor is it aiming for novelty. They publish about 20-30 procedure papers each year, which would be comparable to a single issue at any other chemistry journal. The subjects are well-trodden areas, but often in need of greater detail than is provided in a typical report.
The Walmart website is also a "marketplace". As it stands, the company's website is unreliable for finding goods and their prices and it is full of junk, which requires additional user-based filtering to find items of value. To me that is not "curated".
Parts of this definitely appear to have been traced, although I'm not sure if it was done manually or by a vectorizer.
Around the `OF` in the `FIELD LIST` flow, the green edge has the same perspective change as in the original, cf: https://www.attentionspan.nl/posts/technology/apple-pascal-s...
Lots of other little peculiarities of the original seem to be preserved. So it definitely wasn't re-made solely from reference.
Yes. And for bilingual patients, there seems to be a greater effect on the more recently acquired language:
Southwood et al[49] make the same recommendation based on oral interviews conducted with a single male patient who displayed more language disturbances in his second language than in his native language. Armon-Lotem et al[50] also describe schizophrenia patients who display more problems in their second language than in their first. Smirnova et al[42], in their study of 10 Russian Hebrew bilinguals with a diagnosis of schizophrenia, also found that some syntax and semantic impairments were more pronounced in the later-learned language.
Here's the DOI for their Science Advances paper:
https://doi.org/10.1126/sciadv.adi4386
"miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease"
I feel surprised by how succinct, easy-to-understand, and sensible the policy (M-23-22) is:
Default to HTML: HyperText Markup Language (HTML) is the standard for publishing documents designed to be displayed in a web browser. HTML provides numerous advantages (e.g., easier to make accessible, friendlier to assistive technology, more dynamic and responsive, easier to maintain). When developing information for the web, agencies should default to creating and publishing content in an HTML format in lieu of publishing content in other electronic document formats that are designed for printing or preserving and protecting the content and layout of the document (e.g., PDF and DOCX formats). An agency should develop online content in a non-HTML format only if necessitated by a specific user need.
https://www.whitehouse.gov/omb/management/ofcio/delivering-a...
It's not just a tracking tag on Reddit; the shared links largely obfuscate the thread or comment, requiring one to go through the tracking link to find out what is behind it. An example for anyone curious:
Tracking /s/ link:
https://www.reddit.com/r/Blind/s/xxQGmFcPSS
Leads to the following:
https://www.reddit.com/r/Blind/comments/17atlg7/my_6_week_ol...
Municipal government are starting to realize the costs of suburbs filled with "mcmansions" because the "they generate more property tax" is not true when taking into account the amount of resources they consume and the infrastructure which they require.
https://www.strongtowns.org/journal/2017/1/9/the-real-reason...
Still, many tiny homes projects are unlikely to be generating tax at all, at least those run by the charitable sector. However they can significantly reduce municipal and provincial spending on the needs of caring for the unhoused population. So they are likely to be a net benefit to government budgets.