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mrtesthah

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Is it really a matter of "national security" when the technology at hand is being used in a way that unilaterally benefits a small class of oligarchs at the expense of the rest of society? That's not really in the benefit of the nation anymore, is it?

The illusion works only in places like American and Canadian suburbs in which residents depend entirely on cars for even the shortest trips. Everything takes 10-100x the space due to all the paved asphalt. It’s an intensely alienating approach to building infrastructure.

Technically they are circular episomes — not integrated into chromosomal DNA like HIV.

And we do know that it’s possible to reduce the pool of reactivation-competent HSV genomes by the presence of IFNα during primary infection:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12764766/

This causes PML-NB formation → more viral genomes with H3K9me3 + ATRX → resists eviction by the H3K9me3S10ph “methyl/phospho switch” → stops Phase I HSV transcription (and VP16 expression).

Who’s to say an HPI like IM-250 isn’t altering epigenetic markers in viral episomes in this way? Innovative Molecules’ own press release states that some sort of permanent or semi-permanent modification may take place:

https://www.pharmaceutical-technology.com/analyst-comment/es...

Furthermore, testing in animal models showed that adibelivir affected the latent viral reservoir, suggesting that it has potential as a long-term curative therapy for HSV.

I would say that if this sounds untenable to you, then you may want to consider that the way we architect software has itself been untenable for a while. What Mythos can accomplish today in public, an APT unit can already accomplish in secret.

Kagi Snaps 2 months ago

I love all the customization features but I cannot use them with Privacy Pass sadly. Anonymity is more important to me.