morvita

Antibodies on this scale are not _produced_ by animals. The way these things work is an antibody that binds to a specific target will be _discovered_ by immunizing animals and then screening it's blood or lymph nodes for antibodies of interest. Once an antibody is found and commercialized, it is produced in large bioreactors of cell cultures engineered to produce large amounts of a particular protein (in this case the antibody).

Source: work as a software dev at a company developing antibody drugs

Isn't that exactly what they're doing here? My understanding is Deno is asking the courts to invalidate Oracle's JavaScript trademark, making it a generic term in the public domain. They are not asking for the mark to be re-assigned to Deno.

It worth noting that the power of the neural engine doubled between the A16 and A17 chips (17 vs 35 TOPS, according to Wikipedia), while the A15 to A16 was a much more modest increase (15.8 to 17 TOPS). So it does seem like they started prioritizing AI/ML performance with the A17 design.

Unfortunately, since 2013 Opera is also built on Chromium. They dropped Presto a long time ago.

The article says this system in Vancouver has 300% efficiency, so seems like a problem that works a lot better at scale.

There's power in bargaining as a collective, whether you're a collective of ten or ten thousand. Either way, it helps with the power imbalance between employees and management.

Good news, Apple just announced they'll start supporting RCS next year.

https://www.techradar.com/phones/iphone/breaking-apple-will-...

I've stopped using Uber in my city (Vancouver) and gone back to traditional taxis because they're providing a more reliable service at equivalent or cheaper prices.

The last few times I've tried to use Uber, immediately after matching with a driver they'll message me telling me to cancel the trip because they don't want to go where I'm going. When I refuse, they'll play chicken and drive around in circles refusing to come pick me up and refusing to cancel themselves if they don't want the job, trying to make me pay the cancellation penalty rather than them. When I fly into YVR, it's so much more convenient to walk to the taxi stand and get a ride home within a few minutes for $50, than to order an Uber, wait 20 minutes for it to arrive, and pay $60-80 for the privilege.

Interestingly, there appears to be some localization with that page. I'm in Canada and see:

hello :maple leaf: -> bonjour :fleur-de-lis:

That's funny, I tried Go for Advent of Code last year and got through the first 10 days or so without any real difficulty, having never written a line of it before.

Just as there are different spoken/written languages and people find different ones easier or harder to learn based on a huge number of variables, I believe the same is true of programming languages. Sometimes it's the syntax that makes a language difficult, sometimes it's a different paradigm, sometimes it's an unfamiliar memory model or type system -- there are lots of things that can make your brain throw up a block when trying to dive into a new language.

I've heard so many people say that Ruby is really easy to pick up and work with and for some reason I've had the exact opposite experience. I have tried to learn Ruby at least three or four times and I bounce off it every time. There are a bunch of other languages that I've learned and worked with effectively, but for some reason my brain just refuses to grok Ruby.

The relative costs didn't change for me significantly, I was paying 2600/month USD in rent in the Bay and 2700 CAD in Vancouver, so while it was a significant paycut if you look at the value in USD, the day to day wasn't noticeable.

I really liked San Diego when I visited, if I was going to return to the US, I'd seriously consider San Diego.

I am a US citizen who moved to Vancouver from the Bay Area three years ago.

I took a small pay cut when I moved (from ~135k USD to ~125k CAD, after a few years of raises I'm over 140k CAD now), but certainly not cutting my salary in half. Yes, Canada has its issues, but I'm overall happier living here than I was in the Bay. We have a regional train system that runs every 3-6 minutes instead of the 15-20 you get from BART and better accessibility to the outdoors (I can get to a ski mountain on the bus). I had better accessibility to healthcare in California, but here I don't have to worry about being out thousands of dollars for healthcare if I get laid off.

I work for a smaller tech company founded and headquartered in Vancouver, but I've seen the big tech companies making huge investments in this city over the last couple years. Amazon is in the final stages of building a new tower that will house 6000 employees [0] and Microsoft recently moved into 75,000 sqft of office space and is working on another 400,000 sqft [1]. The tech industry in this city is booming and it's certainly not all driven by companies stashing employees who can't get US visas.

[0] https://www.cbc.ca/news/canada/british-columbia/amazon-canad... [1] https://dailyhive.com/vancouver/microsoft-vancouver-office-b...

My mother was a teacher before she retired to a different state than she'd worked in. She now has to file income taxes in the state she receives the pension from and the state she currently lives in each year.

It's worth noting that roughly half of Canada's population lives in the Quebec-Windsor Corridor [0] (the land between Quebec City, QC and Windsor, ON). This region is really the Canadian equivalent of the Boston-Washington corridor in the States, so imagine if nearly 150 million lived in BosWash.

[0] https://en.wikipedia.org/wiki/Quebec_City%E2%80%93Windsor_Co...

This is why the lifetime of the creator should have nothing to do with copyright terms. All works get a fixed term of 20, 30, whatever years, if the creator dies before that term the rights can be transferred via their estate.

I did a PhD and Post-doc in computational chemistry (focusing on quantum chemical simulations) in the late 2000s/early 2010s and nearly all the software I used was written partially or wholly in Fortran including Gaussian, Q-Chem, Quantum Espresso, and NWChem. Most of the professors I worked with only knew Fortran and had no interest in learning C/C++. The one exception was a professor who was in the process of porting her group's in-house molecular mechanics software from Fortran to C/C++ (don't remember which) so they could get it running on GPUs easily.

I think one of the driving factors in this is that, as other people in this thread have discussed, most of the people writing this software are not software developers and have no interest in being software developers. The scientists trained in the 60s/70s/80s learned Fortran, who then founded their own research groups and taught their students Fortran, who are now running their own groups using Fortran because it's what they know. Some folks use Python for data analysis after their simulations run, but even that was rare 10 years ago.

Which is also based entirely on their market dominance. I'm 100% convinced Google continues handing millions of dollars a year to Mozilla so Google can point at Firefox as competition when the regulators come knocking.

I am pro-union and acknowledge that some unions will protect workers that don't actually contribute to the business, but I think we need a source on unions that drove companies into bankruptcy. That's a pretty extreme case that needs concrete examples.

I actually don't see anything in the OP's comment to indicate whether they are pretending COVID has gone away or accepted that it has become endemic, it's clear that we both interpreted their statement through our own biases.

If we take your more charitable interpretation, I still think it is fair to ask whether we are ok just accepting 100,000 new infections/day of a serious respiratory illness as a normal thing in the summer months, a time that we usually see lower infection rates for this type of illness. For every endemic disease, there is a number of infections that are considered acceptable and public health measures are taken to keep the real infection rates at or below that. I, for one, do not think 100,000 daily is an acceptable number of infections in the US and we should be speaking out to say so. We can collectively do more to bring that rate down, but we don't want to because we're tired of wearing masks on the bus and for some reason have tied protecting yourself personally to a political ideology. We can do better as a society and should be demanding as much from our leaders, not encouraging them to do less.

Given that the EU and US are both seeing around 100,000 new cases daily, no, I don't think the world has moved on.

In the US and Canada (can't speak to other countries), we've collectively agreed to pretend that COVID has just disappeared and return to normalcy because we're tired of dealing with it, but in spite of pretending it's gone away people are still getting sick and dying from this disease every day.

I caught COVID for the first time in July and my "mild" case knocked me out for five days. It was the sickest I've been in ten years and I'm a fit, healthy thirty-something.

In my last two jobs, one in the Bay Area and one in Vancouver, my usual schedule has been arrive at 9, take a 45-60min lunch, leave at 5 and I've never had anyone tell me I'm not working enough or producing enough output.

I've been seeing this problem too at $JOB. Amusingly, the people on my team that use Firefox don't have these issues, but the Chrome users are seemingly losing the ability to screenshare daily.

I actually ran up against this exact problem of IDEs being ubiquitous in the JVM ecosystem at a previous job.

The company had just released a new SDK to access a data repository. Since it was a brand new library, they only had Java/Scala versions, with plans to support other languages (JS, Python being the next two on their roadmap) in the few quarters. My team, primarily researchers who only knew Python, needed to use some of this data for a new project. I figured, what the hell, I've been looking for an excuse to learn some Scala, I'll see if I can throw together a utility for my team to use to get access to this data sooner. I fired up Sublime Text and opened up the docs for the SDK and got to work. The documentation was terrible and I really struggled to do basic tasks with this SDK. Simple things like what types were expected for function parameters was just non-existent. Since this SDK was planned to be released publicly to customers, I thought I'd do my co-workers a favour and sent them a message with some feedback about places where I particularly struggled with understanding how to use their SDK, thinking I could help improve the documentation before this went out to paying customers. Their response was that if I just used a proper IDE for my development, I wouldn't have these problems since the code completion/suggestions would let me know what the types of parameters were.

That experience completely soured me on the JVM ecosystem and I walked away from learning it. When I finally came back two years later, I discovered that I actually really like working in Scala (admittedly I do use Intellij for it now), but that many library's documentation is still quite poor compared to what I've come to expect for Python libraries.

In Canada, British Columbia is using the SMART Health Card as well. Don't know if any of the other provinces are.

I'm not sure how Quebec's system works, but BC's vaccine cards are based on the SMART Health Card [0] standard. The validation app they've put out is open source [1].

I haven't looked at the validation app's code, but I assume the main reason the have their own app instead of pointing businesses to one of the existing SMART Health Card validators is so they can bundle the public keys used for verifying the QR data wasn't tampered with allowing the app to work offline. The SMART Health Card system does provide a way to download the public keys (I've checked and BC does publish them as expected), but it's probably easier to guarantee offline functionality here.

[0] https://smarthealth.cards/index.html [1] https://github.com/bcgov/BCVAX-iOS, https://github.com/bcgov/BCVAX-Android

This maps to my experience (and preferences) well. On my current project, we have a Django backend with a Typescript/Vue.js frontend. I enjoy doing API access and data modelling code in Typescript, but will work to avoid picking up any pure UI tickets for the frontend. If I have to do UI work, it'll mostly be copying and pasting HTML and CSS from other parts of the codebase and writing the Typescript to tie it all together.

Order-preserving dicts were added as a side effect of an optimization in CPython 3.6 [0]. They were considered an implementation detail of CPython in 3.6, it wasn't until Python 3.7 that is was declared an official part of the language [1].

[0] https://docs.python.org/3/whatsnew/3.6.html#whatsnew36-compa... [1] https://mail.python.org/pipermail/python-dev/2017-December/1...

Python 3.5 was declared end of life in September 2020, so it makes sense for library developers to drop support for it as well. Something like Flask 2.0 may work in Python 3.5 (I haven't tested it myself), but it isn't worth the developers' time to guarantee that support for a language version getting no support upstream.

https://www.python.org/downloads/release/python-3510/