HN user

michaelbarton

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www.bioinformaticszen.com 20d ago

You can't rely on LLMs to understand the grain of your data

michaelbarton
1pts0
www.youtube.com 4mo ago

Day in the Life of Enshitificator [video]

michaelbarton
3pts1
www.forbes.com 1y ago

Costco’s butter recall, explained

michaelbarton
60pts251
www.bioinformaticszen.com 3y ago

We're wasting money by only supporting gzip for raw DNA files

michaelbarton
148pts165
twitter.com 3y ago

Null Road, Null, CA, 93401

michaelbarton
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www.bioinformaticszen.com 4y ago

Fear and self-loathing: getting old in tech

michaelbarton
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www.bioinformaticszen.com 5y ago

A problem in bioinformatics: we often don't even know what we want

michaelbarton
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www.independent.co.uk 9y ago

‘Alan Turing law’ in UK to posthumously pardons thousands of gay men

michaelbarton
5pts0
www.bioinformaticszen.com 9y ago

Software development, the happy path, and confirmation bias

michaelbarton
1pts0
www.jaswig.com 10y ago

Show HN: Jaswig – an affordable standing desk for both adults and kids

michaelbarton
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www.bioinformaticszen.com 10y ago

How I develop

michaelbarton
2pts0
www.youtube.com 11y ago

Evaluating and ranking genome assemblers using Docker containers

michaelbarton
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nucleotid.es 11y ago

Why use containers for scientific software?

michaelbarton
1pts0
nucleotid.es 11y ago

Show HN: Nucleotid.es – benchmarking bioinformatics software using docker

michaelbarton
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www.bioinformaticszen.com 12y ago

Bioinformatics software is a disgrace to our field

michaelbarton
4pts0
www.bioinformaticszen.com 13y ago

What the point of publishing?

michaelbarton
1pts0
www.bioinformaticszen.com 13y ago

What's the point of writing good scientific software?

michaelbarton
40pts51
www.ploscompbiol.org 14y ago

Ten Simple Rules for Starting a Company [PLoS Computational Biology]

michaelbarton
28pts18
bioinformaticszen.com 14y ago

Simple functional programming in R

michaelbarton
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www.bioinformaticszen.com 15y ago

Thoughts on presenting software as a poster at a conference.

michaelbarton
1pts0
Claude Opus 4.8 2 months ago

Very good point. There’s clearly two different boxes in the public discourse when it comes to AI versus how we discuss animals. Willing to bet that 90% of the people who loudly make the argument about we should start considering if AI is sentient couldn’t care less about how other sentient animals are treated when they can provably shown to suffer pain and long lasting trauma.

Also I would say that we go much further than just enslavement - specifically looking at how male chickens and pigs are treated.

There used to be a saying along the lines of “while you’re designing your application to scale to 1m requests/min, someone out there is making $1m ARR with php and duct tape”

It feels like this takes on a whole new meaning now we have agents - which I think is the same point you were making

Ah good to know. It’s interesting (to me) how similar they look to each other but you and other commentators below mention how they’re more like distant cousins

I suppose the proof is in the parsing

Yes, It's Fascism 6 months ago

"The Party told you to reject the evidence of your eyes and ears. It was their final, most essential command."

I remember reading 1984 when I was a kid and enjoying it, at no point did I think it was more than sci-fi though. I suppose it goes to show how much we took for granted the last 80+ years.

It also makes me respect Orwell so much more. Which was already very high based on how he makes tea. How was he able to see you presciently?

https://www.orwellfoundation.com/the-orwell-foundation/orwel...

Does anyone have a motion jump plugin they use with neovim they can recommend? I used to use a plugin where you could just to a given character in a given buffer, but I can’t remember the name or if it even works with neovim.

I really enjoyed your article. In regard to the parent comment: it’s also enough to say “I enjoy this and this is how I want to spend my time”. So what if it’s reinventing the wheel - the act of learning and crafting itself can be immensely satisfying regardless of the end result.

I came at your article from a slightly different perspective. Rubio monocoat is quite expensive, especially if you’re trying to run a business selling products coated in it. You’re probably already aware, but I think base Rubio is essentially oil + carnauba + a small amount of paraffin. I make large pieces of furniture, and finishing with Rubio can go through multiple cans! So making my own finish has become a priority. That’s not even accounting for Blacktail Studio coating too.

I think this article is correct in spirit but a little disingenuous in parts. Would it not be more fair to blame Russia as the primary cause for the deaths in Ukraine due to the collapsing health care system rather than USAID subsequently intervening to stop easily preventable deaths.

I say this not to defend DOGE but rather to emphasize that we should always make abundantly clear the humanitarian disaster in Ukraine lies solely with Putin

Speaking from experience I was recently in a tiny fountain pen shop in Sendai[0] where the owner doesn’t speak English and I don’t speak Japanese but we were able to talk for an hour or more about fountain pens and tomoe river paper alternatives using Google translate’s dialogue feature.

Maybe not massive commercial potential but it was pretty amazing and reminded me a bit of the Babel fish which use to seem like impossible sci-fi

[0] https://share.google/64xTBRThXcFR72r3G

Aren’t LLMs being used by business successfully in many “unsexy” domains like translation, sentiment analysis, and image recognition?

Though I do agree that many of the breathless claims that you can stop hiring or even layoff developers because of LLMs seem unsubstantiated

I hope this win signals (to both parties) that voters are receptive and will get engaged when a clear message is presented about cost of living and quality of life issues. Some of which are taken for granted in most other western countries.

I’m no political wonk, and I’m curious what others with more insight might say about his ability to fund and implement his polices.

I’m reminided of Obama and his hopeful message but he was mostly stymied on policy goals. Specifically Obamacare as an example ended up being watered down

RFK Jr. Must Go 9 months ago

There is already a lot of research into this, and as with most things there no one size fits all answer.

“ Along with being more educated and reporting poorer health status, the majority of alternative medicine users appear to be doing so not so much as a result of being dissatisfied with conventional medicine but largely because they find these health care alternatives to be more congruent with their own values, beliefs, and philosophical orientations toward health and life.”

https://jamanetwork.com/journals/jama/fullarticle/187543

Microsoft Amplifier 9 months ago

This reminds me of an an approach in mcmc where you run mutiple chains at different temperatures and then share the results between them (replica exchange MCMC sampling) the goal being not to get stuck in one “solution”