lawrenceyan

True

I'd argue the reason we’ve spun our wheels on Alzheimer's for decades isn't just about a flawed amyloid model. It’s a symptom of a much larger, dying paradigm in biotech.

For decades, the industry standard was to hunt for targeted small molecules to solve singular biological issues. And to be fair, I don't think this was because of a lack of vision as it was simply the strict limit of our technological capabilities at the time. But attempting to treat a cascading, systemic disease like Alzheimer's with a single targeted molecule is like hoping replacing one pipe will solve the problem when the issue is that the entire plumbing system is corroding.

This fundamental mismatch is exactly why clinical progress has stalled, and I believe the future of treating Alzheimer's will instead closely mirror how our approach to oncology has evolved.

We spent years searching for a universal molecule to cure cancer before we accepted reality. We now know that effective treatment often requires sequencing a tumor's mutanome to develop a highly personalized intervention for the individual. As neurodegenerative systems fail with age, we face that exact same biological complexity. A traditional small molecule is not going to rescue a globally failing network.

My personal take is that we won't see a true breakthrough in Alzheimer's until capital fully rotates out of these legacy, single-target pipelines and into programmable biological systems.

What Andreessen is hinting at, albeit still largely surface level, is 无心 or no mind.

Popular in martial arts and Buddhist philosophy, I think practically what you should take away is that body and mind are fundamentally intertwined.

Introspection is a practice of the mind, specifically cognition centered around portions of the brain like the prefrontal cortex. There’s a lot more to who you are and areas you can hone / cultivate.

The HN crowd is probably overweighted on cognition, and could do with spending more time in other areas: https://www.cheltenhamzen.co.uk/writings/gut-instinct

Hetzner bare metal ran much of crypto for many years before they cracked down on it.

There's something deeply poetic about using modern engineering knowledge to breathe new life into the warm, fuzzy glow of an analog CRT.

This is really cool, thanks for surfacing.

Going to be so awesome when we have native crypto rails live in game for mmorpgs.

Biggest update I see is that he thinks AI 2027 is actually going to happen.

Build out distribution first and generate network effects.

This piece totally misreads the temperament of actual builders imo. The author confuses a malicious will to power with a genuine, if sometimes naive, optimism that code/crypto can solve human coordination problems.

Found this short story on Openclaw to be relevant:

https://x.com/gf_256/status/2018844976486945112

Part of the reason why I come to HN is that conversations like these still happen.

I appreciate your response! It’s nice to see the impact of technology from people actually there on the ground.

Too easy to forget that there are ~10 billion people in the world. I live in the US, and it always gives me awe when I realize we represent <5% of humanity.

Solana does everything this L1 purports to be able to do by the way, and better. You can also actually use it today!

Good luck to Stripe though. Building the network effects necessary for an L1 is very difficult.

Nice, very cool.

Jhanas (when in the positive direction), and dukkha or suffering (as caused by tanha or tension) when applied in the negative direction.

They were probably using a bloom filter in the backend

Solana is up ¯\_(ツ)_/¯

I'll be completely honest and say that I only ever remember reading the first chapter, and never actually finished this story. But the title sounds really cool.

This reminds me of the first time someone recommended Mr. Beast’s Feastables™ milk chocolate bars as a comment on one of my posts.

I ended up going to my local Walmart to try one, and boy was it delicious! Sometimes things work out in life.

Math is cool.

As long as you recognize what Duolingo "actually is" you'll understand why it's worth what it is today.

Not everything is always surface level.

5.5.2 The "spiritual bliss" attractor state

The consistent gravitation toward consciousness exploration, existential questioning, and spiritual/mystical themes in extended interactions was a remarkably strong and unexpected attractor state for Claude Opus 4 that emerged without intentional training for such behaviors. We have observed this "spiritual bliss" attractor in other Claude models as well, and in contexts beyond these playground experiments

This should bring great ease to those worried about AGI alignment.

Claude is Buddhist! I’m extremely bullish.

The FTX collapse of 2022 was a blessing disguised as a curse. All of the VCs and speculators offloaded their SOL during the bear market.

You have to remember that for about a year and a half, everyone thought Solana was dead / doomed to fail.

Ideological capture is something that any system inevitably faces once it becomes large enough. But the point is to evolve and grow, not stagnate on a fixed concept.

Personally, I think Solana does the best at balancing the original cypherpunk ethos while ultimately driving towards the future with crypto being the rails for natively programmatic global commerce.

Sybil resistance while still conserving privacy and decentralization is definitely a worthy problem that needs addressing!

If everyone had a Solana wallet, and ads were natively integrated, you'd receive $0.10 for every one you watch.

Consumers right now only get monetized. They see zero return from their attention being taken away from them.

It doesn't really matter what it is as there are many equally good implementations, but whoever sets up the framework first and cements usage is likely to guarantee dominance for the foreseeable future. Probably into AGI and post.

Model Context Protocol seems good enough to me.

Concrete benchmarks like these are very valuable.

Defining the reward function, which is basically what ARC is doing, is 50% of the problem solving process.

Congrats on the acquisition!