First, I agree with your comment.
But since you specifically bring up omeprazole: I backed off of pantoprazole by getting a prescription for half-dose pills (since they're time released, you can't just cut them in half), then decreasing frequency (alternating days, then tapering off) and retained the benefits.
There are plenty of confounding factors in my case, but checking occasionally if you can back out of a drug is worthwhile.