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javiermares

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Someone knowledgeable please advise:

Do cryotherapy or cold showers increase the risk of developing Alzheimer's disease in the long term?

"Tau phosphorylation is exquisitely sensitive to temperature, increasing by 80% for each degree below 37°C, due to exponential decrease in PP2A activity during direct hypothermia, or anesthesia-induced hypothermia."

This means that one might expect a significant increase in tau phosphorylation from modest decreases in body temperature, possibly leading to increased risk of Alzheimer's in the long run.

Source: https://www.nature.com/articles/srep00480

Hold on, it's not comparable to the ~10$ CAGR of the SP500 is it? RenTec's fund is capped so it's an average return of 71.9% but not an annualized return, since the returns are not compounded. Correct?

Building a car is an engineering project. Building a new kind of car will be a science intensive engineering project, but an engineering project nevertheless. Designing a new car is an attempt at optimizing a high dimensional design space that spans many disciplines that are interdependent. This requires fundamentally different methods and organization than those used conventional research.