Dropping alot of weight rapidly can lead to gallbladder issues. If you're on a GLP-1 please look into this and ask your GP about potentially putting you on Urusodiol.
I saw a thread on reddit where a GP chimed in and mentioned that he was giving urusodiol to all his patients at the same time as GLPs, to help prevent the associated issues.
Either way, modern science is great. Just do your research.