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heuermh

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Mammoth Biosciences

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I mostly use it for learning things. How does this guitar pedal effect work? Why does this Eurorack module sound so good? How can I drive this MIDI instrument from this OSC controller? etc.

Ideally there would be an easy path from ChucK to implementing all of these things in hardware but I haven't quite got there yet.

https://github.com/heuermh/lick

I have been using ChucK for a long time. Like others here, I appreciate Max/Pure Sound but would rather use my text editor.

  Delay delay;
  LPF filter;
  Reverb reverb;
  Gain feedback;
  
  adc => delay => filter => reverb => dac;
  filter => feedback => delay;

Thank you for writing up your experience!

I have done a ton of Swing over the years, and also a 2.5D zoomable scene graph API called Piccolo2D [0], which was one of the inspirations for JavaFX (or so I heard at the time).

As far as your advice, I will take a look at swapping Batik out for EchoSVG, and also see how you tackled the user data directory issue in KeenWrite.

[0] https://github.com/piccolo2d/piccolo2d.java

I was at ISMB [0] and BOSC [1] conferences earlier this month and Venn and Euler diagrams were all over the poster session. Not sure why, but biologists love them!

I wrote an implementation of Venn and Euler diagrams for the bioinformatics data visualization application Cytoscape many years ago [2]. Sigh, thick clients in Java haven't aged all that well.

[0] https://www.iscb.org/ismb2024/home

[1] https://www.open-bio.org/events/bosc-2024/

[2] https://apps.cytoscape.org/apps/vennandeulerdiagrams

All the time!

My most recent were tools to improve the AWS commandline experience for s3 and Athena

https://github.com/heuermh/cooper

https://github.com/heuermh/sea-eagle

Both are available via Homebrew

https://github.com/heuermh/homebrew-parquet-tools

I would next like to improve the TUI experience for tabular data, e.g. using the Charm_ Bubbles/Gum table component, but I have yet to investigate how the JVM <--> Go interaction might work.

Cool! I have a 128k Mac in working but not restored condition, reach out to me if interested.

I also have a 512ke, which I'll not be able to part with, as it was my first computer. Still runs the copy of HardBall! I hacked to use the roster from my baseball team!

Hang in there, lots of folks having similar experience!

We have been pretty impressed with the closed-ish loop of the Dexcom and Omnipod, it handles daily fluctuations due to more/less exercise etc. fairly well.

Still two separate handheld devices though, and quality always falls off when the sensor (every 10ish days) and pump (every 3 days) approach expiration.

DuckDB 0.8 3 years ago

Nice to see Parquet support in DuckDB improving with each new release! In earlier versions, I had trouble with enums and nested schema, these issues have been resolved since.

The only missing feature for me now is full table, column, &c. metadata support in the DuckDB JDBC driver.

Thanks!

Had a glance at the team page on the Mammoth website, curious to learn more about how the various roles fit together. Mind sharing a way to get in touch?

We presented using Parquet formats for bioinformatics 2012/13-ish at the Bioinformatics Open Source Conference (BOSC) and got laughed out of the place.

While using Apache Spark for bioinformatics [0] never really took off, I still think Parquet formats for bioinformatics [1] is a good idea, especially with DuckDB, Apache Arrow, etc. supporting Parquet out of the box.

0 - https://github.com/bigdatagenomics/adam

1 - https://github.com/bigdatagenomics/bdg-formats

I've been writing effects in ChucK for several years but have found it difficult to deploy to various platforms of interest.

Is it possible to build an effect written in Glicol into an iOS app or effect (AudioUnit v3? haven't been keeping up)? LV2 plugin to run on MOD devices guitar pedals? VCVRack, which has its own plugin interface? onto a Rasp Pi Zero?

As good a thread as any in which to post this, anyone else with a basement full of electronics parts interested in federating a web store for one-offs and interesting finds?

I have acquired plenty of cool stuff, but nothing in significant enough quantities to make it as an electronics supplier. I'm thinking more curated antique store vibe.

I got to use an SGI Octane for a while and fell in love with its keyboard, just the right amount of clicky. I later acquired an entire box of 'em, so hopefully those will last the rest of my lifetime.

Feel free to reach out, username at berkeley edu.

In open source bioinformatics we strive for reproducible science, which can be difficult in a field with tons of different methods and tools. One approach is to use a workflow language such as Nextflow [0] and Docker/Singularity such that the entire analysis is reproducible, see e.g. [1].

There is a vibrant community around Nextflow workflows called nf-core [2] which has a rare disease workflow in development [3], come join our slack!

[0] https://nextflow.io

[1] https://github.com/brentp/rare-disease-wf

[2] https://nf-co.re

[3] https://nf-co.re/raredisease

Totally agree! I would suggest adding KIR as well. Curious what your background/interest is?

I have consulted to National Marrow Donor Program/Be The Match [0] off and on for several years. There are typing labs using long reads but most reporting/matching/analysis is still performed at the nomenclature level [1].

I hope in the near future we'll be able to simply assemble the entire MHC for each sample, as messy as it might be, see e.g., "A diploid assembly-based benchmark for variants in the major histocompatibility complex" [2].

[0] https://bethematch.org [1] https://www.ebi.ac.uk/ipd/imgt/hla [2] https://www.nature.com/articles/s41467-020-18564-9