doctorpangloss

if i recorded the video of "private home sequencing," what scene would be different? i suppose you would put the sample collector into some kind of not-yet-existent affordable device? and then what, you get an sd card?

all the value is in the analysis and sharing.

define insecure or exploitative. it is a very shallow argument to say, iNsUrAnCe cOmPaNiEs - genomic data harvested by insurance companies will never benefit the consumer, but we already have laws against that scenario, the technology doesn't really matter. or the narrow situation with, something something, medical research derived from tissues and the tissue-donators not given a just compensation? i don't know if that's exploitative. and people are already walking, insecure DNA-donators. you are surrounded by easily deanonymized DNA samples everywhere you walk right now...

okay, it's interesting that you chose those three goals, i would have picked three very different goals (i support your mission don't misunderstand me). here is an illuminating reason why:

let's say i recorded a video of the ENTIRE end user experience of (A) collecting the genomics data with your solution (B) using an existing solution. which scene in the video would be different?

see, the problem is, not a single scene would be different.

i appreciate this kind of funny commentary but on the flip side, compare the top software list in 2026 - facebook, instagram, tiktok, gmail, youtube, chatgpt, ios camera, google docs, office on ios, android and windows - and two of those were created during 2010-2016, music.ly (tiktok) and instagram. perhaps the environment you describe is really good at creating social media phenomena. i don't know if i'd call it "innovation" but i'm not that judgemental. nonetheless most of the reason things were "good" in 2010-2016 is that the period contains most of the growth of iphone and android adoption (the inflection was in 2013). you are looking at cultural stuff that could be the exact opposite - it could be heavily burdened with management, Apple and Microsoft and their little ecosystem of partners certainly were - and still find success. so another takeaway is, none of that stuff really matters now does it?

It's a very interesting project. What are the big picture goals? I am asking from the POV of having spoken to many people in the genomics data ecosystem, such as pharmaceutical "chief commercialization officers," not just engineers.

Oh god guys let me make your ads product for you

anyway i was completely wrong and a few nodes had EDAC events haha

I just had an LLM set it up and never had to touch it again.

i have years and terabytes of ECC DDR4 and DDR5 memories, UDIMM and RDIMM, with edac enabled all this time, and i have literally never once observed a single error correction. however, (1) i built all these computers myself (2) the servers are located on the middle floor a thick, concrete multi-story warehouse-to-office conversion. as others have said, on a correctly built computer, the source of bit flips is cosmic radiation, and there is a lot of mass between these machines and the sky.

the story is kind of complicated, it's impossible to guess the culprit, you must profile. HDR content for example can sometimes incorrectly request a bespoke tonemapping instead of a video engine silicon one, like it does in libavcodec, or you have a privacy setting in your browser that breaks GPU compositing. so many little things can go wrong unfortunately.

imagine being the leadership of the one of most valuable US private companies in the world. then you have to make something called a "pull request" that gets "reviewed" by someone named "Jarred" to make improvements to your stuff. do you see how that is untenable?

the language is relevant for political not technical reasons. you could say, blanket closing the Issues, getting rid of this thing called Jarred from your stack, etc., is really an attack on the GitHub and the GitHub Agitator Lifestyles, which is why so many commenters on Hacker News actually care.

I would want to put stuff on the camera, which this SDK doesn't do. But it's good it is part of their DNA.

They could spur a lot of innovation by open sourcing their firmware or introducing plugins. They don't really have a channel to take asks like "ring buffer style recording" but I would do it myself.

A great value if you pirate games.

being able to draw a picture of a pelican is really cool and it requires intelligence but i don't think it's a good measure of improving capabilities of these models nor AGI. we don't have to spend so much breath on it.

reduce harmful blue light

enough studies and randomized control trials have been conducted, it is conclusively shown that blue light emitted from household devices does not interact meaningfully with sleep. metareview CRD420251034611 "non-significant reduction in sleep onset latency" means blue light has been conclusively observed to not delay sleep - it doesn't mean that blue light has not yet been observed to delay sleep, we instead know conclusively that it does not. even better, a registered trial one: https://clinicaltrials.gov/study/NCT01855126 - RCT where shining a bunch of blue light on old people's eyeballs didn't help them stay awake longer (going to bed too early is actually a more common clinical issue than staying up too late). well if it can't keep people awake, it doesn't keep them awake.

it's a great interview question though. "does blue light from screens cause sleep delay?" it doesn't. why do so many people think it does? why suffer with a piss colored screen?

based on their apple intelligence demos they are optimizing their products for their core demo of 55-95 year old boomers who talk out loud to think and read every page of the nytimes. you are miles away from the US consumer product experience here.

Lots of ebike manufacturers have pulled out of the US, and lots of US ebike manufacturers have gone bankrupt.

It is nice to have a lot of competition for phones.

The contraction of the US market and lots of government interference with tariffs is not good.

they train on your requests by paraphrasing them (which means rewriting them but keeping all the saliency) and removing their association with you

i don't know why this is so controversial, their terms are written to perfectly fit this training regime. one of you downvoters i'm sure has an enterprise contract with them, just ask.

if you are using bedrock, until very recently, they didn't see your requests and could not paraphrase. but too many people were using bedrock for too much stuff they wanted to see. so that's why the terms for bedrock changed for fable 5. this was the core of the palantir / defense dept drama with anthropic.

okay, what if this benchmark were just called Arc, and all you knew about it was what questions it asked? it just looks like a bunch of arcade games, which should tell you that it doesn't test AGI at all.

on the flip side, the idea that most tests are bad, even standardized tests, the tests that you scored well on that gave you all your opportunities in life: it cuts to the emotional, grounded core, the absolute foundation, of too many people. in the crowd of hacker news commenters; people who buy anthropic shares at retail; the people who work at tech companies; and their kids, families, etc., who are a bunch of nobodies, there are a lot more incentives to believe "stupid fucking arcade games test AGI" than not.

what do you think will come of the people who have to ingest large amounts of information for reasons other than producing joy, if the AI is ingesting large amounts of information for them?

and anyway... the commenter is doing this for joy. so who, really, are you even talking about?

why be snarky? i agree, your AI is going to make the tedium in your job easier.

i just wonder why you think fees are high. seemingly the only thing that keeps fees low elsewhere in the world is regulations.

Look I'm the one who made the error here. All I am saying is that AllowedIPs doesn't do what it sounds like it does.

I see that you don't know what AllowedIPs does :)

haha self hosted wireguard, an opportunity to find out AllowedIPs: 0.0.0.0/0 does the opposite of what you think it will do

On the flip side does this stuff add up to a greater cultural impact than playground drama nostalgia? Can I write this without being downvoted?

The idiocy of cooldowns speaks for itself.

Insurance companies don't invent anything, they don't control interest rates, don't risk much of their owners' money, and in many cases the state obligates people to buy your service, so in that sense it's easy.

To me, the hardest part is competing for the small number of intelligent people who are interested in such a dull, fundamentally scammy business.

Haha the better question is can the notepad++ guy go after notepad++ (for mac)?

is "Notepad" a bigco IP project name?

imo, its purpose is to be independent, because raising rates (combating inflation) is unpopular. otherwise, its job is pretty simple, it does't take much expertise, gravitas or technology to choose the number or to say no to the president.