darthvoldemort

I think Siri gets some of its results from Wolfram Alpha.

Dan, you're protecting tptacek from criticism which is absolute bullshit. I very fairly criticized his lack of reading comprehension, and the fact he's not an expert in anything except for security. What he accused me of in his comments was worse and protecting him is bullshit.

He came in attacking me twice and you do nothing to his account? He didn't even read my post and then started his rant about the vaccine when I wasn't even talking about the vaccine.

If you're going to threaten with banning, I suggest you do it to everyone fairly, even if he's one of your "favorites". You should be flagging his posts, not mine.

Plus, you flagged my perfectly accurate post on how thalidomide is safe, it's the chiral version of it that causes deformities?

I have this book, it was such an important and informative book at the time. It's so interesting that such an important book filled with a wealth of knowledge doesn't have much use these days.

I'm suggesting that sometimes a very small amount of a substance can cause catastrophic effects a decade later. That's why we do testing before we release drugs.

And Pfizer isn't the hero here, they never have been.

https://corporatewatch.org/pfizer-six-scandals-to-remember/

This list doesn't even include Celebrex.

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.

Pfizer also made Celebrex, the anti-inflammatory that they knew caused health issues but they buried them and claimed it was safe.

We are living in an upside down world now. All of a sudden the drug companies are the "good" guys. Since when did the drug companies suddenly become the heroes?

https://corporatewatch.org/pfizer-six-scandals-to-remember/

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.

Prions are "just" proteins that should get broken down by the body. But they don't, and they cause ‎Creutzfeldt-Jakob in over 10 years after ingesting.

I'm skeptical about the idea that Substack has poor support.

I just listened to Chuck Palahniuk on Joe Rogan. He still writes on pads of paper, but he said Substack hand-held him and he loved it, and called Substack a "concierge service" and he said he enjoys Substack because it let's him concentrate on writing and not worrying about the tedious parts like formatting, etc.

It's a huge pivot to go from flipping houses to becoming a landlord. It would essentially be a disaster for them. That's a high-touch business and probably the costs associated with it, and the legalities around it are too complex. That's basically turning into an Avalon or something.

The interesting question is around their bonds. They were basically convertible bonds which likely triggered, but now they have to pay back the cash. How much of a liquidity crisis will this introduce to the company?

The more interesting thing is that this business crisis won't be reflected in their last quarter 10-Q which should be coming out soon. I'm assuming this is going to be talked about in that earning call, so that will be an interesting one to listen to.

I think Opendoor's model is a lot better, but I guess we will have to wait to see if there are any repercussions to their business.

Actually your comment is pretty bizarre.

You're distilling your impressions from thousands of people into a single sentence, and then you're taking a single person's response and using that to push your agenda that "people just love to hate big tech". It's fascinating that you think this is a valid observation on your part.

Have you asked your coworkers for advice?

One thing you have to accept is that there is a problem with the way you communicate. People would not be going to HR if you were as unemotional as you think. So seek out advice and honest feedback from your friends, your coworkers and your family. Maybe you can find an expert in communications that can point out what the flaws are and how to correct them.

But DO NOT sweep this under the rug. There is a problem here, and it sounds like no one wants to help you fix it. That's probably another indication that there's a pretty bad problem.

Libertarians are absolutely not neoconservatives or fundamental Christians.

That's like comparing a Democrat with Antifa.

Same thing happened with Tom Cruise a while back. He fired his publicist and started to go on interviews, and it turns out he's fucking wacky. He was jumping on couches on Oprah and laughing maniacally, and doing other really weird stuff. People were shocked, and his star dropped for a couple of years.

Lesson learned. Keep your mouth shut and let people think you're stupid, instead of opening it and confirming it.

You don't have to be a social butterfly to be liked. You just mainly shouldn't be an asshole.

And the key is to consistently not be an asshole, otherwise those things will accumulate and you will eventually get rejected. (I'm not accusing you of being an asshole.) If you're nice 90% of the time, but lash out or say shitty things 10% of the time, that's more than enough to get eventually rejected.

My son, unfortunately, is like this. 95% a sweet kid but 5% really, really shitty and saying mean things. We are working on it. He started out immensely popular but over the course of this school year, his classmates look at him lukewarm now, instead of being his close friends, and it's entirely his issue.

How can the SEC and the Treasury let these crypto coins continue to exist when it's so rife with scams? Based on the TOS of Tether, it's clearly as scam with no protections for any investors.

Why hasn't the US government regulated all these coins out of existence? I feel like it's turning into a systemic risk to our economy given how much money is being turned towards them.

NTSB and NHTSA can't investigate every single complaint. That's unfortunately not scalable. They would need to talk to the driver, talk to Tesla, get the data, etc. All for something that's handled through civil lawsuits. You can sue the driver because ultimately she is at fault, and if she wants to sue Tesla, that's her prerogative.

This makes sense to me.

Yes, it's a little. A 20% increase over a small number is still a small number. I'm not talking relative risk, I'm talking overall risk. Most overweight people still have mild symptoms or were asymptomatic. The single factor that had the highest predictive factor for complications was age.

Except most obese people don't have issues with COVID. This is the thing that is most confounding about COVID. Most comorbidities only increase the risk factor by a little. The biggest and most reliable risk factor is age. We know there is almost no risk below the age of 5, and 15% chance of death over 75.

I collect comic books, and I collect limited edition rock n roll photos.

I do have a vast collection of digital comics, probably 250GB worth, but I also want the joy of actually owning some of them, looking at them, and reading them.

What they really mean is that they need a new generation of Greater Fools to sell their collections to, otherwise the value of their collections will completely deflate.

I've seen this exact same discussion on comic book boards that I frequent, where some collectors worry that Golden Age and Silver Age comics may drop in value because they don't have as much meaning to newer collectors, who buy Modern comics for different entirely reasons. It's kind of a funny discussion to me, since they are literally trying to keep a Ponzi scheme going at the expense of younger people and new collectors.

Maybe I'm too old, but I don't know a single person with Oculus, not even among my younger coworkers.

I don't discount that it could be the next big thing, because wtf do I know, but it feels very niche to me, and certainly not something that can get the engagement like a phone can. And in terms of money, Facebook itself is a printing press, I wonder what the business model is for this? Selling games or experiences? Billboards in an AR world?

Borrow money from friends and family if you have to. Expensive lawyers can do a lot of things that ordinary people can't do. I would do thorough research on this to figure out who can do this type of work for you. I think it's the most likely to be successful and if I were in that situation, that's exactly what I would do.

It's also a reason why I gave my kids very, very generic boring names which would make it very hard to google them.

You should invest money into fighting this legally.

If you are the victim of cyber bullying then I would suggest contacting the platform that is housing the libelous posts. I think there are ways on every platform to remove libelous posts. You probably should hire a lawyer to handle this for you that specializes in cyber bullying.

If you were fired over this libel, then you could also sue the company as well and make sure there are press releases that state that you are fighting this as false so that they become higher in the search rankings. Then at least if future employers are looking at this, it will call into question whether or not you are actually guilty.

I have a VERY similar experience with my first job, except 10 years earlier.

My first job was in IT at a bank. I was working with Windows NT and a migration to Windows NT 4.0 across the entire company. I learned a hell of a lot about Windows NT but I knew I wanted to be a programmer. So every day after work, I would just program on my own, doing various projects.

After a year and a half, I interviewed for a programming job at another company. I 100% lied and said I was doing programming at the bank, but was able to pass the interview questions (this was mid-90s so they weren't anywhere as difficult as they are today). I got the job, and from then on I could label myself as an actual programmer.

I wonder if you could track down who Satoshi is based on someone's search queries about Secp256k1 specifically

HN is HN. It ebbs and flows like the tide. I love HN for what it is, a news feed of interesting articles, with a bias towards technology but not always. I've been introduced to so many things because of the wide range of articles that are fascinating to like-minded people.

I'd like to see conversations about software, hardware, computer science, and hacker culture resurge and dominate here.

Feel free to upvote the articles that you enjoy. But forcing HN to only be about the above would probably lead to its demise.

After your question, I asked me friend, and she said it's so damn confusing what the rules and borders are that it's easy to get confused.

You are exactly the type of person who is pushing out the best kids into private school. Private schools in California are getting record numbers of enrollment after how horribly public schools handled the pandemic, and after how it wants to gut programs in the name of "equity". Your kind will reap what they sow, because it will create a 2 class system where anyone who can afford private school will go there, leaving essentially the economically most disadvantaged in public school. And along with the students, people will fight to cut money to public schools as well, since many will be paying for private schools.

Kids that are advanced need to be with other advanced kids. Not all kids are equal in ability. Using weasel words to push an agenda of "equity" that hurts the best and brightest is what will kill public education and push moderate Democrats such as myself to voting for Republicans who want vouchers to gut the public education system.

old.reddit.com

100 years ago China was barely a country, ripped apart by opium, politics and various countries that occupied China. It took Dr. Sun Yat Sen and subsequently Chiang Kai Shek and then Mao to get China back on its feet and now is a global power because of its 2 billion people.

But you can't compare the innovation of China to the US... for the time being. Admittedly the inflection point is coming soon if the US doesn't get it's head out of its ass.

You know nothing about teaching and education if you think this is going to help. It's going to hurt even more. The reason why you group children with similar learning abilities together is so that they can progress together. If you stick advanced kids with less advanced kids, both sets of kids will suffer because the advanced kids will be extremely bored and the less advanced kids will get discouraged because the advanced kids are so much better than them. It goes against the fundamentals of education.