chkaloon

Cool! I was at least hoping for an op amp or two for the circuit however ;)

Glad to see the special mention of the Mat Su Valley in Alaska. Lived there for 10 years, originally from Wisconsin. And yes, the two are VERY similar. Not the exactly the same, I did notice a difference when I moved back to WI, more nasal. But the Mat Su Valley was populated by Midwestern farmers during the Depression, so it makes sense.

Massimo Pigliucci's favorite phrase. Used to drive me insane listening to Rationally Speaking

Glad for the Disney reference. Before it became a marketing arm for Pixar movies it was an awesome venue for an optimistic future in Tomorrowland and then Epcot. It's a shadow of that former glory unfortunately.

Awesome. I think I'll put in an open records request for the cameras down the street in my little Wisconsin town. See what happens

Too late

They know Sam has few scruples and will go for the money if the DoW says jump. These clauses mean zilch if Sam is involved

Depends on the project. For web based functionality it seems great, because of all the prior work that is out there. For more obscure things like Obsidian Note extentions or Home Assistant help it's more hit and miss

Years and years away unfortunately. Many trials and chances for failure on the human side.

It's discouraging to see these on HN and then realize that most never go anywhere, or are so far out you may not see it in your lifetime.

Maybe we should flag anything not already in a phase 3 trial :)

Useful tho

I'm always suspicious of articles like this. Having been part of a company that was the target of a few NYT articles, there is always more to the story. And parts that are just flat out wrong, but not being an expert or in the industry you just need to take their word for it and believe their anecdata.

Thanks for this. Brings back so many memories of the long hours spent in computer rooms with HP 9000s and RS/6000s back in the 90s. Seeing that SAM interface made me shiver :)

It's great that there are folks like you preserving this history

LAN Manager legacy still hanging around after 40+(?) years

I would extend Yankeedom to the Mat-Su Valley of Alaska. Wisconsin, Minnesota colonists in the 1930s and more recent western Michigan transplants.

So cool that the are people attempting to preserve this amazing, sometimes lost, history. I hope they are considering how to preserve their own work as they do this.

Here I thought ST Discovery had jumped the shark with its whole mycelium navigation plot device.

The article mentions alcohol consumption by kids, but I think it doesn't emphasize enough the effect of efforts like Mothers Against Drunk Driving and strict DUI laws. Back in the 70s and 80s having a few drinks at a party, bar or friend's house was normal and part of the social lubrication. Even drinks during lunch was common where I worked. No more. You either need to have a designated driver, find a taxi (which doesn't exist in most rural areas), or just not drink. The first two are a pain, so people opt for the latter and that social inhibition hangs around, and folks go home early. Have to get up for work in the morning, you know.

Can we just keep taking courses of scorched earth antibiotics until we come up with a microbiome combo that feels good?

Some legislators probably have constituents that just won't shut up about it, so they figure let's pass this since it doesn't actually ban anything that actually exists and get these crazies off my back.

I'm thinking "effectuate" could be interpreted as requiring force if necessary. Since this is another country, that would be outside the purview of a court to mandate a military action. They can require that the govt "facilitate" El Salvador's action to return him.

Screen time.

I also thought it was interesting when basketball essentially added 1 second to each game by including tenths on the game clock

This doesn't address the screenshot of Elon's X admin page in the background of one of Adrian's posts

Since this group probably has a high propensity to consider all taxation as theft, I think it applies better here.

So if they are going to do this, can we get a signed affidavit from then that they will not call 911 and use taxpayer funds for a transport to the local ER when things go south? If so, then I'm all for it.

Good code review method, but that doesn't address the anxiety aspect, which is real.

I always tried to treat and see it as a teaching and learning exercise and not make it accusatory or negative. As a reviewer, see it as an opportunity to teach others in good code practices. As a reviewee, see it as an opportunity to learn, not as a slam on you personally.

Doesn't solve it completely, but it helps.

ChatGPT to the rescue:

Here is a rewritten version of the passage at a 10th-grade reading level:

Most proteins begin to fold into their proper shapes while they are being made on the ribosome. Studies have shown that the way proteins fold during this process, and the energy involved, can be very different from how they fold when they are refolded outside of this process. Until now, it wasn't clear why the ribosome affects protein folding in this way.

In this study, we looked at the detailed structures of an unfolded protein both on and off the ribosome. We found that the ribosome causes the unfolded protein chain to spread out more and increases how much it interacts with water. This makes the protein chain less stable when it's on the ribosome compared to when it's alone. Tests using 19F NMR confirmed that this instability makes it easier for the protein to start folding on the ribosome, lowering the energy cost by up to 30 kcal/mol. This helps the protein form partially folded shapes, which are necessary for some proteins to reach their active forms. These effects also help protect the protein from unfolding due to mutations, suggesting that the ribosome plays an important role in how proteins evolve. By linking the structure and movement of the protein chain to how it folds and behaves after folding, our findings explain why protein folding on the ribosome is different from folding after translation is complete.

"Hear from I". Man that grates every time I hear it

But it does frequently cause nasal congestion, unrelated to sexual simulation

Bryan Caplan should take a clue from his bit of introspection.