Don't forget the replication. S3 replicates to at least three other AZs in the same region. I know this still doesn't account for the difference but its worth remembering.
The tooling side of things is surely a pain, but it's getting better. I liked the project.json style, so i'm a little disappointed they are moving back to csproj.
Aside from that, it's a great, intuitive, fast framework that we use in production and I love it more every day. I'd chose it again and again.
Watch out for the lack of performance monitoring solutions available so far. Most of them haven't got support for .NET Core yet. New Relic does not.