carlsborg

Good for humanity, and also GDDR/HBM manufacturers.

Correct link is https://queue.acm.org/detail.cfm?id=3819084

AUR is just a collection of user-produced PKGBUILDs.

Is that much different from the entire pypi ecosystem, and npm, and dockerhub (people disable Selinux, --privileged turns off seccomp and apparmour, sandbox escape CVES exist)?

Pipeline is then: Cheap open source model for flagging potential LLM refusal content -> main LLM check

Intriguing... "After months of misdiagnoses Dr Souhel Najjar, employs a test asking Susannah to draw a clock. Instead of the customary clock face, her condition led her to draw all the numbers 1 through 12 on the right side of the clock. This was the breakthrough moment; it was this clock drawing that enabled Dr Najjar to understand that the right side of Susannah’s brain was inflamed, further test revealed this inflammation was a result of anti-NMDA receptor encephalitis, initiating her path to recovery"

"Memory plus search is all you need"

Now the echo of my system prompts are bouncing round the room.

edit: Bouncing around the room is one of their hit songs. Give it a listen.

"since 2019, on the advice of the National Agency for the Safety of Medicines and Health Products, French health workers have been told not to treat fever or infections with ibuprofen." [1]

But yet in some countries pediatricians will libreally prescribe it to toddlers

[1] https://www.bmj.com/content/368/bmj.m1086

Also from [2] "In this systematic review of NSAID use during acute lower respiratory tract infections in adults, we found that the existing evidence for mortality, pleuro-pulmonary complications and rates of mechanical ventilation or organ failure is of extremely poor quality, very low certainty and should be interpreted with caution."

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.1451...

Perhaps in due time we will see workload specific forks of Linux maintained by a team of agents

Anthropic/OpenAI could own this space. They should offer a paid service that offers a mirror with LLM scanned and sandbox-evaluated package with their next gen models. Free for individuals, orgs can subscribe to it.

“ The agent acted like a hyperparameter optimization algorithm with some basic reasoning baked in.”

Good lens.

The crux of the auto research repo is basically one file - program.md which is a system prompt that can be summarized as “do this in a loop: improve train.py, run the training, run evals, record result. Favor simplicity”. The other files are an arbitrary ML model that is being trained.

3I/ATLAS first detected on: July 1 2025

Gamma ray burst that kept going for seven hours, fired three distinct bursts spread across an entire day: July 2 2025

just saying

This is why Montana Civil Defense survives when skynet goes rogue.

Should have funded the entire GIL-removal effort by selling carbon credits. Here's an industry waiting to happen: issue carbon credits for optimizing CPU and GPU resource usage in established libraries.

The solution is ironically, LLMs. You can construct a set of Claude skills to walk you through a code review, or understand code (anything, even course) fast.

This complexity to understanding compression will be a big market going forward.

I will add : "The Design of Design" by Fred Brooks (of The Mythical Man Month fame)

Acquired in June 2021 for $1.8 billion usd. Hurts but acquirer Naspers is a prolific tech investor, its stake in TenCent is worth > $150B usd today.

Unless you're cross platform on Windows too and then theres also a vast number of random registry settings.

People should vote on art and if you hit a threshold, you get the income.

Arguably the most familiar desktop user interface on the planet. I often wonder why complex web apps do not use this searchable start menu format.

They released a paper. Preprint linked in page.

Both are broad spectrum antivirals, but completely different mechanism.

DRACO "is a chimeric protein with one domain that binds to viral double stranded RNA (dsRNA) and a second domain that induces apoptosis when two or more DRACOs crosslink on the same dsRNA." (Ridder et al 2011). This article is about packaging mRNA for a set of 10 interferon-stimulated genes that express multiple proteins that target various stages of viral replication.

Paper appears to be paywalled. It is however an update to this preprint which is available on Biorxiv: "Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency" https://www.biorxiv.org/content/10.1101/2024.06.24.600468v1

My summary for programmers:

When you get a viral infection, immune cells make a signalling protein called a IFN-1 (Type I Interferon) cytokine, and this flips a boolean flag to True on a bunch of genes (interferon-stimulated genes or ISGs) that produce a bunch of proteins (hundreds) that control the infection. ISG15 is one of them and its role appears to be to downregulate and to limit the inflammation.

The paper title refers to a ISG15 deficiency, meaning if you are dificient in ISG15 that inflamation limitation goes away. But the paper is actually about how in people that naturally have a ISG15 deficiency, there is an always-on low level expression of some of these pro-inflamation genes. So they take that as a safe level.

The did RNA sequencing on experimental ISG15 deficient cells and from heatlhy individuals, identified the mutations, narrowed down to 10 genes (antiviral ones not inhibitors) that in combination significantly inhibited viral replication. They stuck the RNA for such genes in lipid nanoparticles such that they enter host cells, whose ribosomes happily read the RNA like a turing head reads a tape in base 20 and produce proteins encoded by these genes, similar to how the mRNA vaccine works.

So why not dose with the IFN-I directly? Three referenced papers show its "poorly tolerated with significant side effects" and all those downregulators that get expressed limit the inflammation response.

Disclaimer: IANAB (not a biologist) corrections might be due..

Maybe we can crowd source data. My platform, currently in beta, has ai assistants for compute infrastructure and biology and will soon let people to do self serve research on their own omics data using models like yours. So there could be a monetization path too if enough people start looking their own cell data (which they might once they fully understand the risks of engineered pathogens, and certainly will when the risks materialize and start hitting home). Email in bio if you want to brainstorm.

Cool. Could we train a "potential oncoprotein" classifier on Orthrus embeddings? IMO self serve diagnosis and detection is a far larger market than synthesis.

Opus is already severely crippled: asking it "whats your usage policy for biology" triggers a usage violation.

"Earth has 4550 satellites in orbit"

Rapidly obsoleted information. SpaceX alone has > 7500 satellites in orbit. It added 2,300+ satellites in the one year period ending Jun 2025.

Also not to be confused with:

* Threonine: One of the 20 base amino acids, forms proteins. You need to get it from a food source.

I thought people were dosing themselves with a base amino acid. Duh. Theanine is an amino acid found in green tea, but not a base amino acid, ie doesn't form proteins. Can cross the blood-brain barrier and can certainly modulate brain function.

Not to be confused with:

* Thiamine: Vitamin B1, a molecule your body does not produce so you a get it from a food source. Needed for biochemical pathways that convert carbohydrates into energy. Not an amino acid.

* Thymine: One of the four nucleotide bases in DNA, pairs with Adenine. Synthesized in the body from the pyrimidine synthesis pathways

The great filter: light years of travel needed by detection probes.