byteCoder

OpenNext on Cloudflare is the only way I've successfully gotten NextJS to work in a Cloudflare Worker.

https://opennext.js.org/cloudflare

Airlines need to qualify aircraft for passenger-carrying transoceanic operations.

Northwest Airlines would often use their new wide body aircraft for domestic operations to meet the qualification requirements to operate long distances.

I was a participant in a trial of the TIL therapy at NIH in 2012 for stage 4 melanoma. I chose to participate in this trial because it was retraining my own immune system to fight my cancer.

Within three months of treatment, 99% of my tumor load was gone (with the remaining was unknown if it was active malignant cells or scar tissue). By 15 months, there was no evidence left.

In the last 11+ years, I've had no further treatment and the melanoma has not returned. I'm very lucky to be a complete responder and have a long-term remission.

When TIL adoptive cell therapy works, it works well. It's amazing, and I'm thankful for Dr. Steven Rosenberg's life work in developing this.

Now that it's FDA approved, many other melanoma patients will have a shot to try a therapy that, for all practical purposes, can be a cure for a disease that not too long ago was a terminal death sentence.

"There are only two hard things in Computer Science: cache invalidation and naming things."

-- Phil Karlton

Interesting. I had zero issues using my Amex in France and Switzerland this past summer. In fact, there was only one restaurant that I visited that wouldn't take it. I must have been lucky.

Yes, such treatments have been in trial for a couple decades at NIH, showing complete response in a segment of the patients for certain cancers. The therapies harness each individual's immune system to direct it's attack to the mutations specific to their tumors.

Iovance is on the brink (should have been approved in the next month or two, but has been delayed because of "staffing shortages" at the FDA) of getting FDA approval for Tumor Infiltrating Lymphocytes adoptive cell therapy.

Besides the special labs used for the cell processing (managed by Iovance), the therapy is not a whole lot different from stem cell transplants, so any hospital that helps patients with blood-bourn cancers can provide this new therapy to melanoma (and soon, other cancer) patients.

P.S. I'm an 11-year survivor post-TIL therapy for Stage 4 melanoma at NIH.

At the time NT came out, it wasn't 100% POSIX compliant, but close enough for government work.

One stipulation in NT's subsystem at the time was that fork() needed to be followed by exec().

In elementary school in Wisconsin in the 70s, we lost our milk cartons in favor of the bagged milk.

Although it may have been sold as eco-friendly, the real driving reason was cost reduction: it was less expensive to package and transport milk in plastic bags than in small waxed cardboard cartons.

The protocol in linked study appears to be similar to the melanoma therapy I underwent at NIH, except for the CAR-T part.

The study I was part of was published in a few papers, including: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295669/

From my personal experience with advanced melanoma under a trial at NIH almost 12 years ago, Dr. Steven Rosenberg and his research team:

1. Surgically resected a tumor and removed the tumor attacking T cells in a lab,

2. expanded them in a lab to 130 billion,

3. returned them to me after making me immunosuppressed, and

4. kick started my new immune system with high-dose IL-2.

Within three months, my tumors were essentially gone.

I’ve been cancer-free since.

It seems to me that the body doesn’t have enough of the right T cells to fight the mutated, cancerous cells.

Note: I have TSA Precheck and CLEAR.

I'm not sure how someone could get through with the incorrect identity unless their eye scan results in the record of someone with the same name.

The process for CLEAR is:

1. Stand next to the kiosk for recognition. For whatever reasons, the machines always seem to have problems with me, but eventually get a good scan and bring up the correct record.

2. Scan your boarding pass at the kiosk, which (supposedly) validates that you're on a flight at this airport and that your name matches what's on the boarding pass.

3. You're escorted to the TSA agent, the CLEAR agent vouches for you, and you just wave your boarding pass in the air to the TSA agent (no scanning).

Often (including this week), I get flagged to show my identification to the CLEAR agent and to the TSA agent. Ultimately, I could have gone through less hassle with simply the TSA Precheck line.

Many times the TSA Precheck line is actually faster. However, when that line is backed up (usually at certain airports like DCA), having CLEAR is a winner. YMMV

Here's a link to it: https://www.khoury.northeastern.edu/about/dean-elizabeth-myn....

My son just graduated from Northeastern University's Khoury College of Computer Sciences.

At his Khoury College graduation celebration a week ago, this is the first time that the following oath was recited by the graduating class:

KHOURY COLLEGE OATH FOR COMPUTING

Today, I join the ranks of computer scientists worldwide.

I will remember that I remain a member of society, with special obligations to all my fellow human beings.

I will design and build computing systems that enhance the quality of daily life for individuals and for society.

I will protect the dignity of users and others affected by computing systems, respecting the diversity of all cultures, and safeguarding against threats to health and safety.

I will respect the privacy and rights of all people and recognize the special role I have in judiciously collecting, storing and using their information, and creating systems that aim to shape their behavior.

I will work for fair wages; honorably guarding my reputation and my colleagues in our work practices, while respecting the intellectual contributions of others.

I will improve the public understanding of computing and its consequences.

May I always act to preserve the finest traditions of my field, and may I long experience the joy of inventing the future through my endeavors.

Correct. The bike path was designated and two-way.

I was certain the driver saw me when he looked to the right and we made eye contact, but apparently he was looking in my direction beyond me toward the street.

As a cyclist (on a designated bike path), I was hit by a small SUV in case #2.

The driver looked to the right and I thought our eyes connected, but he proceeded from the stop sign to make a right turn right into me. Fortunately, he stopped as soon as he knew he hit something and I only ended up under his bumper, with a slightly bent up bike and major bruise on my left thigh.

In this case, I would have actually been safer (and in better view of this driver) if I had been riding on the road.

Up to that time, I rode over 1,000 miles outside in the summer, mostly on roads. Now, I no longer trust traffic at all and ride mostly on the extensive bike trail system in Minneapolis-Saint Paul metro area, except when I consider the road to be a better option.

The thought of sharing the road with distracted drivers and other drivers who choose to be assholes to cyclists makes the road riding just too risky.

No paywall version: http://archive.today/2021.12.29-072341/https://www.nytimes.c...

The article describes the use (and subsequent abuse) of the Qualified Small Business Stock (QSBS) exemption that has been in US tax code since the 1990s.

I'm sorry you're going through this.

It's very difficult to be a caregiver and, without a doubt, the additional burdens that places on your life make finding the life/work balance even harder. And, then, you have the emotional aspects of having a loved one in their journey.

As a software consultant who simultaneously was a patient (Stage IV melanoma) and a caregiver to my wife (Acute Myeloid Leukemia) with two kids (tween and teen) nine years ago, it was definitely a struggle.

Some suggestions:

* Don't be afraid to ask for help from other friends and relatives to lessen your burden.

* Schedule time for yourself on a regular basis to take a break from the situation. (I personally started regular cycling and yoga, but YMMV.)

* Communicate with your manager and colleagues to help you get some work flexibility. Of course, remote work opportunities will give location flexibility, as there is often a lot of waiting between scans, appointments, and treatments.

* Seek a professional therapist if you need someone to help you sort through the tangle of issues in your head.

I wish you mental peace as you travel this unexpected journey with your mom. It's not easy, but it is possible to navigate this rough patch in life and come out better and stronger on the other side.

Actually, the ][+ was still 40-column, uppercase. I remember wiring a pin off my keyboard controller card to the paddle button input and add a replacement character ROM to get lowercase support.

It was the //e and //c that had built-in lowercase support.

You can actually see the date palm that was studied at the Arava Institute located in Kibbutz Ketura in Southern Israel, just north of Eilat.

https://www.atlasobscura.com/places/judean-date-palm-methuse...

Illegal and unethical: yes, in this use case.

But, let's give Kevin serious kudos on his clever approach to solving this problem. This is the true hacker spirit that reaches across the decades. Bravo!

Optical mice existed prior to Microsoft's IntelliMouse.

In 1989, I owned an optical mouse (Logitech S9?). The biggest issue was that that mouse required a special gridded mouse pad.

This is Marketing 101 on how to make your customers and potential customers feel that you're ahead of the curve when you're really behind and you need to buy some time.

Also, haven't we all learned yet that the publicity and discussion this is generating reenforces the connection between AT&T and 5G in people's minds, even if it's technically incorrect? The facts don't really matter.

Earlier this week, I tried out Strava's mobile implementation, which did not work well for me at all.

I'll definitely be sticking to their web version, which they've had for years.

I miss a real ESC key. I can’t tell if I’ve pressed it or not, which is problematic when using vi and touch typing. Haptic feedback would be a nice add-on to make it a little more tolerable.

Also, Apple’s default configuration with Siri in the upper right was a horrible design decision. It only took me a few hours of use to decide to reconfigure the Touch Bar’s layout.

I found it interesting that even an Apple Genius Bar employee was recommending a third-party app to me: BetterTouchTool.

I lost my wife just over five years ago after nearly 21 years of marriage. The grief process is complicated.

Without a doubt, focusing on the here-and-now and being grateful for the support and encouragement I received (and continue to receive) from family, friends, and even strangers over the years has helped me get to a place of peace and acceptance in my life.

Like the article mentioned, the unexpected kindnesses of acquaintances and strangers absolutely helped me through this process.

If you're ever in doubt about reaching out and letting someone in need know that you're thinking about them, just do it. It is helpful.

As a melanoma survivor, I'm no longer eligible to be an organ donor. In fact, I could even donate blood until the American Red Cross changed their guidelines for eligibility in 2017:

Benign cancer or tumor: Acceptable to donate

Basal cell carcinoma: Deferred for four weeks after date of surgical removal

Squamous cell carcinoma (skin, cervix, or oral cavity): Deferred for four weeks after date of surgical removal

Malignant cancer (e.g., breast, prostate, or colon cancer and melanoma): Deferred for one year after treatment is completed

Leukemia, Hodgkin’s and non-Hodgkin’s lymphoma, and myeloma: Ineligible to donate permanently

Kaposi’s sarcoma: Ineligible to donate permanently

Since the treatment was performed on site at the National Institutes of Health using Federal research dollars, this wouldn't have been an option. So, I have no idea.

From an economic perspective, cures (or, even, long-term durable remissions) are definitely disruptive to the current models of care.

Yes, harnessing the patient's immune system to fight their cancer is a very promising technology and is saving the lives of many patients, even more as the processes and meds get further refined.

Yes, the treatment was obviously totally worth it. And, I'm extremely grateful for being in the lucky 30% of patients who response completely to it.