biomcgary

My teenage boys are hooked on Calvin & Hobbes.

In Lakatosian terms, the amyloid hypothesis is an example of a degenerating research program that has largely failed to predict new observations and is primarily driven by post hoc reasoning. The hypothesis was rescued by research claiming a significant new observation that was ultimately shown to be fraudulent (https://pmc.ncbi.nlm.nih.gov/articles/PMC12397490/).

From a Lakatosian perspective, the amyloid hypothesis is not necessarily wrong, but it is not paying off in terms of empirical insights relative to the amount of attention and funding it has received.

But, datacenter development in space does not deal with local NIMBYs, just centralized decision-makers that are easier to "influence".

Gives new meaning to "gut intuition", since the superparamagnetic macrophages are in the liver.

My CEO did a deep dive into AI prototyping and eventually ran into a wall with data architecture and deployment. Fortunately, he realized very quickly that having human designed core infrastructure is what enables vibe coding that doesn't run off the rails.

Your username is uncanny for this comment. Well played.

The fact that you aren't persuaded is the evidence of collapse. Previous generations of LLMs persuaded everyone of anything.

I'm a non-Conformist is the historic sense. In the past decades, American Christianity has devolved into a smorgasbord of personality cults and group therapy that effectively suppresses the freedoms that many Christians fought for at the country's founding. Not usually overtly, but the prison is in the mind (or its lack of use).

Do you know if any of these multi-stage approaches can run on an 8gb M1 Air?

Computational biologist with a focus on predicting individual human health at a startup, but I have ended up managing software engineers. (Scientist explore and engineers make the science work in production.)

This explains the Scotch-Irish settling in Appalachia. It felt like home, but without the overbearing Brits nearby.

The Readme for a UI library benefits enormously from screenshots, even terminal based UIs.

The mind-body link is too important to get the causality wrong and The Body Keeps Score is an ideology where the causality only goes one way.

I have a cousin that had frequent, overwhelming anxiety attacks. She started eating breakfast consistently and the anxiety disappeared at the same time. Anxiety is strongly linked to gut activity, so the temporal correlation is a smoking gun, even if not dispositive.

For her, "understanding past trauma" was irrelevant to the solution.

Billions of cell derived from Henrietta Lacks agree with you.

I think you are getting at the need for tiered layers of abstraction and constraint. Simultaneously considering all possible ways to solve a problem doesn't work for humans or the LLMs derived from our use of language. The repeated use of Domain Specific Languages (DSL) in the context of a general purpose programming language gets at this same need to constrain solution spaces within a reasonable boundary.

Once we have quantum LLMs, the need for intermediate abstraction layers might change, but that's very [insert magic here].

Available data makes causality hard to get right. This paper is trying to get around known constraints with observational data (e.g., some people stop drinking when they start having noticeable problems). Mendelian randomization tries to infer how much a person drinks from their genetic variants. However, the genetic tendency to drink might be associated with the same variants related to dementia. The summary doesn't make it clear if this was addressed.

I didn't see a public source repository for keet, just compiled releases. Why would you trust closed source for a privacy app?

How does this avoid carrier grade NAT if everyone is on a cellphone?

The language around emotion often obscures the underlying reality that needs to be addressed. Emotions are the physiological manifestations of expectations and desires. (Emotion is etymologically related to motive.)

The person your responding to clearly has a desire to do productive work with minimal roadblocks. In one person the roadblock to that desire/expectation might manifest physiologically as depression, in another person as anger, and in another as detachment. Getting rid of the roadblock is what needs to happen regardless of how the emotion manifests.

This does not mean that emotions are not addressed, but that they are addressed primarily as signifiers of a mismatch between the world and one's underlying desires/expectations, not the thing itself.

Sometimes, the desire/expectation of an individual is counter to the good of the overall system and group of people. In this case, a good manager might start by explaining the larger situation so that an individual can update their desires and expectations through the additional knowledge. Then new thinking/perception shifts the physiological experience of those desires (i.e., emotions).

In other cases, the gap between desires/expectations and reality is too big to bridge, which means emotions cannot be resolved in the current context.

True, in traditional corporate structures. I'm interested in how accountability flows in cooperative structures like Mondragon. (Accountability still flows down through those at the top, as far as I can tell, but there is an aspect of bottom up accountability too.)

normal

I bought a TENS 7000, which is #1 in Amazon's "Muscle Stimulators & Accessories" category. Mine came with a 9V battery. The specific "tens ear clips" that I purchased are no longer on Amazon, but similar ones are around $20 for a pack of 3-4.

Note: some people place electrodes on the tragus, as in this paper, but others stimulate the concha. Tragus needs one two pad clip, concha needs two one pad clips. The rubber pads are just slightly bigger than the eraser of a number 2 pencil.

I forgot to mention that the entire setup is about $60 on Amazon, so, for the HN audience, the biggest factor to trying it will be your time and/or intellectual aversion to non-mainstream medicine :-).

I use a TENS unit with an almost identical setup to the paper (ear clip is the same, duration is the same, frequency is 30hz instead of 25hz).

My use of vagus stimulation is for managing anxiety and promoting digestion / gut motility. I have neck issues that probably impinge on this nerve, contributing to these symptoms. Evidence suggests that the effect isn't purely psychosomatic; when laying on my back with TENS, I observe an increased frequency of GI tract "gurgles" relative to off. The observable product of my GI tract has also normalized somewhat.

I think the best way to actively read is to write down your own thoughts as commentary.

That's an interesting interpretation but a quick search didn't turn up the first version of that until 1861, so it seem rather late to have influenced EO iconography. Perhaps you are familiar with earlier examples of that interpretation?

Impetuous or not, Peter was likely influenced by the many decisions made by lots in the Hebrew Scriptures. e.g., picking a scapegoat (Leviticus 16:7-10), assigning priestly duties (1 Chronicles 24), dividing land (1 Chronicles 6:54), etc. Furthermore, Proverbs 16:33 & 18:18 indicates the outcome of lots is from God and reduces conflict.

Anyway, ascribing random processes to the divine for decision making, particularly political situations seems to have strong textual support within the Judeo-Christian tradition. I'm curious about parallels in Islam and other offshoots.

There is an interesting example of random selection of leadership from the Bible when the apostles replaced Judas. The criteria were agreed upon and then lots drawn.

Acts 1:21-26 Therefore it is necessary to choose one of the men who have been with us the whole time the Lord Jesus was living among us, beginning from John’s baptism to the time when Jesus was taken up from us. For one of these must become a witness with us of his resurrection.” So they nominated two men: Joseph called Barsabbas (also known as Justus) and Matthias. Then they prayed, “Lord, you know everyone’s heart. Show us which of these two you have chosen to take over this apostolic ministry, which Judas left to go where he belongs.” Then they cast lots, and the lot fell to Matthias; so he was added to the eleven apostles.

Can you imagine this practice replacing the Papal conclave? Or, pastor selection at your favorite Protestant group?

I'm curious about whether FydeOS would get in the way of technical work or just be another Linux for most things?

Now to finetune my local LLM on the sendkeys syntax, add kyutai for streaming voice recognition, and my mac will be fully voice operable.

To me, the non-local focus of EA/rationalism is, at least partially, a consequence of their historically unusual epistemology.

In college, I became a scale-dependent realist, which is to say, that I'm most confident of theories / knowledge in the 1-meter, 1-day, 1 m/s scales and increasingly skeptical of our understanding of things that are bigger/smaller, have longer/short timeframes, or faster velocities. Maybe there is a technical name for my position? But, it is mostly a skepticism about nearly unlimited extrapolation using brains that evolved under selection for reproduction at a certain scale. My position is not that we can't compute at different scales, but that we can't understand at other scales.

In practice, the rationalists appear to invert their confidence, with more confidence in quarks and light-years than daily experience.