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ben1040

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www.stltoday.com 4y ago

Missouri prosecutor declines to charge Post-Dispatch reporter

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10pts0
www.youtube.com 6y ago

The Beauty Of Espresso In Slow Motion (1,000fps in 4K)

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makezine.com 8y ago

TechShop to Reopen Locations Through Asset Acquisition

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en.wikipedia.org 8y ago

Fisher Price PXL-2000

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android-developers.googleblog.com 8y ago

From Chrysaor to Lipizzan: Blocking a new targeted spyware family

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tools.android.com 9y ago

Unofficial Copies of Android Support Libraries Being Distributed on JCenter

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www.treefinder.de 10y ago

EULA prohibits use in EU countries with large immigrant populations

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newsroom.uber.com 11y ago

Introducing UberLETTERS

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stlouis.cbslocal.com 11y ago

Taxicab Commission Chair Says Uber Outrage Is ‘White Privilege’

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krebsonsecurity.com 11y ago

St. Louis Federal Reserve Suffers DNS Breach

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fox2now.com 11y ago

Missouri lawmaker proposes requiring ID for mobile payments

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github.com 11y ago

Ferguson Grand Jury transcript index

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jakewharton.com 12y ago

Google Play Services 5.0 Is A Monolith Abomination

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secureworks.com 12y ago

Synology NAS Boxes hijacked for Dogecoin Mining Operation

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arstechnica.com 12y ago

Your Android phone viewed illegal porn. To unlock it, pay a $300 fine

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www.fitbit.com 12y ago

Fitbit initiates voluntary recall of Force tracker

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online.wsj.com 12y ago

Fitbit Wristband Users Complain of Rashes

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plus.google.com 12y ago

Google offering prescription frames for Glass

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nest.com 13y ago

Nest Acquires MyEnergy

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stampedecon.com 13y ago

StampedeCon - Big Data Conference, St Louis July 30-31

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www.att.com 13y ago

AT&T Announces Intent to Build 1 Gigabit Fiber Network in Austin

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blog.azimuthsecurity.com 13y ago

Unlocking the Motorola Bootloader

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www.bongizmo.com 13y ago

Resources every Android developer must know

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www.washingtonpost.com 13y ago

Supreme Court upholds first-sale doctrine on items sold abroad

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www.space.com 13y ago

Longest-Running Earth Observation Satellite to Retire

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plus.google.com 13y ago

Google I/O 2013 Announced: May 15 - 17

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developers.google.com 13y ago

Google Civic Information API

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arstechnica.com 13y ago

Judge Alsup orders Oracle, Google to disclose paid advocates

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www.reddit.com 14y ago

Reddit IAmA with Pebble Watch founder

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greenpois0n.com 14y ago

Crowdsourcing iOS jailbreak exploit detection

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There are more consumables involved there beyond just reagents and a lot of it was/is proprietary. The machines all had their own consumable physical bits for sequencing as well and getting your hands on those would also be a blocker.

Applied Biosystems Sanger capillary machines (the 37XX series) had polymers that were injected into the capillaries to reflow between runs (the polymer took the place of the physical slab of gel). The capillaries themselves were also consumable and would wear out after so many runs. They were extremely expensive even 20-30 years ago when these were state of the art. You also need the dideoxy dye terminators you read about in the article. The patents on BigDye are expired now (the patents were ABI's principal moat on the Sanger tech and they aggressively used it against competitors like MegaBACE) but it's not like that's a growth market for a vendor trying to make a generic replacement.

Similar with the 454 -- the process would fragment up the DNA into lots of tiny shards, and bind the fragments to microscopic beads. There was a physical flow cell chip that you would flow the beads onto. The chip had microscopic "beehive" cells to hold the beads such that you had a vast array of miniature test tubes running reactions in parallel while the machine imaged the result. These chips were one and done after every sequencer run, and were precision manufactured. They were manufactured by fusing together a bundle of fiber optics and then slicing it like bread, such that you had a glass chip and the space between the fibers became the cells. You'd need the beads, the chips, and the reagents to produce the reactions the machine is looking for.

Without all the reagents and physical necessities these machines are just some really fancy cameras with onboard lasers.

Long story short it's fun to think about getting one of these machines, but unless you use it as a cool looking coffee table that appeals to graying molecular biologists, you're going to be disappointed.

I worked in this space for over a decade. It's so weird to me to see the workhorse sequencing hardware like the ABI 37x/37xx series, 454, and Illumina machines now as literal museum pieces.

I've been watching the Québécois version of Taskmaster with community-made subtitles and I love how the subtitle writers have included brief idiomatic explanations for the swearing that is constantly peppered into the dialogue.

It's me, I'm too lazy to modify a keyboard.

I came upon a spare Touch ID keyboard. I just got Command strips and adhered the whole keyboard to the underside of my desk. USB cable is clipped to the desk and goes to my dock. I've got the fingerprint reader right next to my standing desk controls so it's really convenient, and I still get to use my Keychron as my keyboard. The low profile of the Apple keyboard means it doesn't get in the way.

Also every time I need to unlock my Mac or sudo I get to feel like I'm tripping the silent alarm at the bank.

Much of the early part of the Human Genome Project was done using gel based DNA sequencing machines that were controlled by Classic Macs.

The rest of our shop was Solaris on SPARC/x86 and we had our own custom tool chain that crunched the data, but the sequencer itself was run by a Mac.

From 1999 or so forward the next generation of machines were Windows.

I have a UniFi doorbell that I chose because it's self hosted and the video stays in my home. It also easily lets you get an RTSP stream of the camera feed.

Earlier this spring we put a bird feeder outside the front door and it dawned on me I could be piping the doorbell cam into BirdNET to classify the bird calls. With an RTSP stream there's no need to mount a microphone anywhere, that comes for free from the doorbell.

My wife is the bird person in the house more so than I am, but it was still really fun to set up and watch the identifications come across.

20+ years ago during undergrad my OO design class had us writing C++ on Solaris. We were told that unless it compiled and ran on Sun we'd get a zero.

This was also before ewaste regulations came in and some engineering school departments would just throw decommissioned hardware out on the loading dock for people to pick over. One day a pile of SPARCstations showed up and my roommates and I grabbed them all.

We put together two working SS-5s by picking and pulling parts from about eight of them. Had our own mini Sun lab in our living room so we didn't have to go out in the snow and try to stake out an open machine in the engineering computing center.

I'll never be able to read about us digitally unrolling fragile scrolls without it seemingly like otherworldly sci-fi technology.

I similarly had my mind blown reading an article last week, about how sports & game card collectors are now having their packs CT scanned so they can identify what cards are inside (and the value of the pack) while keeping them sealed.

https://www.nytimes.com/athletic/5987857/2024/12/12/trading-...

30 years ago I was a teenager a friend of mine had a giant plot of empty land in his family, and so we'd go out there and do stupid teenager things things like playing with fireworks and building and shooting potato cannons.

We'd discovered dry ice bombs alongside internet plans for potato cannons, and in our infinite wisdom we tried to build a dry ice bomb powered potato cannon. In our mind the sudden increase of air pressure would've sent the payload going ridiculously far.

Thankfully when we went to use it the first time, we were smart enough to run as far as we could before it went off. It was far far more pressure than the pipe could handle and it sent little bits of PVC shrapnel flying everywhere.

I flew some overseas trips on Delta 767s in the late 1990s that still had the tube headphones. I was pretty intrigued by the concept, you could hold your hand up to the tube holes in the arm rest and hear the music echo off your hand.

Either on the headphones themselves or in the little overwrap bag there was a note to leave them on the aircraft when you deplane, because they (obviously) wouldn’t work elsewhere.

Cooler screens 3 years ago

Just loved this quote from the Cooler Screen people:

When you think about it within the context of "I'm in front of an ice cream door and I want to buy," you have the ability to isolate the message to exactly what a consumer is focused on at this point in time based on the distance that they are from the door.

This also is achieved by a sign taped to the glass saying “ice cream, buy one get one free,” but where’s the VC money in that?

Also NACS locks the cable on the car side while CCS locks on both sides. That means with CCS, a malfunctioning cable can strand your car.

I'm just surprised they didn't consider when designing the standard that they're putting a critical moving part on the component most subject to handling and damage.

Public charging connectors get just beat up from constant handling from lots of different people, many of whom couldn't care less about the next person to use it.

In the 1980s there was also LEGO/LOGO, a programmable interface to a line of Technic products, plus an expansion card and breakout box for the Apple II to wire it all up.

There were motors, lights, and sensors you could program. One project I remember was build a car with a light sensor on the front, and then write a control loop that uses the sensor to make the car follow a line on the floor.

Here’s a blog post about someone exploring the tech:

http://lukazi.blogspot.com/2014/07/lego-legos-first-programm...

Google Pixel Fold 3 years ago

I wondered what was up with them and actually found an interesting read about it on the way.

https://www.wired.com/story/we-tried-vertus-web3-phone-it-sc...

“Vertu has changed hands lots of over the past decade, but is still being run by a bunch of folks based out of Hong Kong, very close to the Chinese supply chain,” says Neil Shah of Counterpoint Research. “These folks with renewed focus are rebadging existing models from brands—ZTE, for example—with luxury materials and advanced hardware and software.”

During my bi-annual dentist visits they always mention the sealants on my teeth (maintained with the last touchup done when I was 16) and I'm sort of surprised they're largely intact. I'm 41 and haven't had a cavity since I was 13, on an adult tooth that I just missed my chance to get sealed before the cavity happened.