archlight

Novavax UK results on par with mRNA vaccine while trials conducted with variants alpha/beta already circulating. due to unbinding or cross over we cannot really measure long term protection. but several studies show 2373 is better but nobody knows it

well we already have this protein based vaccine Novavax 2373 with cross immune response based on prototype developed 2.5 years ago. because it not only has full representation of spike protein (unlike mRNA taking shortcut to represent S protein) but also cleavage site which is omicron BA5 immune escape from. However big pharma politics slowed down the approval, purpose delaying US P3 trial, introducing CMC requirement 1 month before formally submitting the application. Novavax 2373 has shown superb efficacy results since Jan 2021 UK trial and follow up study showed long term protection (titers half life 9months compared to mRNA 3months). no myocarditis risk. still FDA only approved it now half year after submission blaming the company's manufacture issue while it has been distributing hundred of millions of doses worldwide mRNA is not vaccine. it is only genetic therapy

I am quite keen to research/trading engineer role in Singapore. I applied before and got interview for ops dev role. are they within same department or research engineer role demands higher skillsets?

Young American are wealthier than European. In Europe wealth are with old people

i think US gov should set up H1B audit committee to audit all interview records and summon HR head to testify on hiring practice in the big corp. any fraud will be treated like financial fraud which results in prison term.

if students cheated in college and their parents are sentenced to 5 years, i think HR head should be treated as same

this is great idea. you need guided tour when you visit a museum as vast as louver

paywall backed by one econ theory

Efficient Markets Hypothesis If you had paid enough for the page, it would have appeared.

well put. I recently had this thought that dev is no difference from production line worker. There are only small fraction of dev sitting on top of pyramid designing blueprint and managing production line.

I am in this situation where I really hope I could apply some risk framework to help me make decision.

I recently signed an offer with a company, US bank with large python community. Now I am counter offered with more pay and promotion and internal transfer to a new team. Conventional wisdom is never accept counter offer. but this one I am giving second thought as it is not for original role but transferred to new team. I will be only one in my location and I will be building MVP for business users. it will be exposed to a lot of tech stack but it won't be scale as large as new company.

However to join a new company, there is always uncertainties like team and project. I had bad experience before. It is difficult to find it out through interview only. It seems to confirm this as I find that hiring process is a bit not taken seriously. It is greenfield project but no coding tests. There is no front end expertise in the team so I was only got asked things like "you worked with angularjs right?". Hiring manager is recruiting three altogether which he thinks will be good team.

risk is about managing uncertainties. I hope decision like this can be priced so it is easier to decide.

I am in the minority group of fast sleeper but it is more to do with my blood stickiness. sometimes I am a bit scared as it is too quick.

I see people who has CS background like to talk about performance, go deep into the subject. the common question asked how python list implemented. I reply variable array and interviewer is happy. To be honest i haven't noticed list has to resize when appending more items. probably i haven't seen real world problem.

I think there is some special code unknown to outside developer league that they can test and know you are real developer

I met one asking are you package users or know the underhood.

Your interpretation is well said. I am doing that 80% stuff. it seems to deliver a lot and feel like developers currently I am writing very defensive codes which not addressing problem directly. I just want to get it done quickly.

I belongs to get-shit-done camp. It is so easy to check if someone has packaged a module for you. like if mongo call is blocking in tornado, i don't wrap it with coroutine. simple search i found motor/tornado redis/etc. only during debug, occasionally I jump in their codes and get idea how they do it. but that is only out of curiosity.

my work doesn't have collaboration other than users. if they want realtime feed, i do quick meteor app just a bit more complex than quick starter tutorial. I really want to break into serious development

Thank you for your advice. The problem with my current job is I am one man team building tools for less than 20 users. I am not using Jenkins. usually I check out codes from servers and simply copied in share drive. They only saw code snippets in codepad. I think the way I talked doesn't seem like I am working in a professional team.

I have never worked in a team, doing peer coding/review. It is good to have this practice so people feel you are in their league. and usually through teamwork you get questioned and spot your area for improvement. I am kind of doing this through interview but that is really waste of opportunity this way.

it is really good tool. we have tons of spreadsheets at work. instead of building automatic solution, we are looking for quick way to recreate them. we built a tool to attach function to extend data pulled from db. It would be good to pipe data between different components which means each component has I/O ports. very inspiring works

Although HN becomes front page of internet for me nowadays, it is still good idea! for submission part, it saves round trip to NH if article has been submitted

This is really cool. I tried a few c++ call as endpoint in a webservice. but i find it difficult to maintain state as you know market are in memory. I am also thinking to recreate dependency graph as futures in tornado but I gave up as it seems too difficult. eventually I just move xll out of excel process to make it s/s a bit light weighted and faster to run

If it can be solved beautifully, it would be cash cow. like the others mentioned, translating UDF (user defined function) would be a challenge. also in bank, it usually load quant library xll. It would be impossible to host quant library as service. nowaday i see bank just use spreadsheet as front end. a lot of logic are wrapped in code and fully tested somewhere else

I really hope google will buy twitter so it can put back real time search in twitter stream a few years ago as an experiment.

In singapore, work permit class are all based on salary you earn and associated rights. EP1 above 8k you can apply long term visa for your parents. EP2 above 6k you can think about applying permanent residency. SP you cannot bring your own spouse. WP you cannot marry to local.

It is a bit brutal. but effective.

IT outsourcing is like training you while you on pay. once entry level engineers get experienced and they will ask to migrate to US. eventually a local hire become out of job.

Things I don't understand is why all these IT jobs require degree. why cannot we train school dropout to do the works? don't listen to outsource company when they say we have 80% graduate/16% masters/4% PHD etc. see what skills you really want.

Agree. I am still having difficult times to locate music i favored. after i switched off data for apple music, it didn't warn me when I start it and i thought it is down. i switched back to spotify now

It paves way to start a war by ripping off legal framework first like "versailles treaty". Germany earns the trust to be responsible country to do peacekeeping overseas by reconciling with neighbours. Japan is different story. it hasn't even shown any gesture of sincere apology.

American and Chinese education learns to balance each other for the average students. for the ultra smart,they do what they are good at. when I was at high school in china, I can solve complex algebra and geometry problem which I don't know how I did that today. I never thought public speaking or organisation skill etc is skill. I have the wrong belief like how you can talk about it if you are not expert of it. now in china people already start to reduce difficulties of maths problem in exam and pay a bit more attention on soft skill. in US, people might think to equip american kids with more math skill so that in future they can embrace more discipline. one example i see good programmers not willing to do computer graphics because they are worried about their math skills. maybe that is why post like maths you need to know for programming is popular

it is a good news. because American become more confident in educating their kids in maths and abandon the idea that you can be lawyer if you are not good at math. on the other hand, Chinese can stop believing that math is highest form of intelligence and pursue career as lawyer etc.

Singapore set up NUS high school a couple of years ago to nurture development of students talented in maths and science. I remember a ex IMO coach from was hired from China to prepare for the competition. it is not surprising it stands at tenth place if you have long term plan for it. btw 6 mio people are total population out of which only 3mio are singaporean. but if you are really talented and wealthy, you can quickly become singaporean

what about if you already start working during the commute? it is "shortening time" travelling to work.

people will say India is largest democracy on this planet. all the things you see are temporary and will resolve itself because this political system has been working well in many places. I will then ask, well, when this is gonna happen?

I like this idea. on one hand it helps yourself avoiding same mistake by putting it down as words, on the other hand it benefits other

that is why he is great man. when you are abandoned against you believe is best for your country, he didn't give up and come up with even better solution.

It is good initiative. I am looking for a job in US without immigration intention. I just want to spend good time in vast land with beautiful nature before my 2 years old son goes to school. currently we stayed in city state on tropical island. it is clean and civilized and low tax. but just nowhere to go during the weekend other than air conditioned shopping mall. seriously I am open to be exploited