So you are proposing that chemicals cause aggresion in rats, and aggression in humans, but for a different reason? Seems unlikely to me.
Double blind experiments do show causation (ignoring metaphysical discussions).
There are 3 possibilities: Chemical -> Behavior, Behavior -> Chemical, or ??? -> (Chemical and behavior).
A randomized trial eliminates the latter two possibilities (since chemical is correlated only to a coin flip). Double blind eliminates experimenter bias.