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adi4213

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Claude Opus 4.8 2 months ago

There's just not a lot of juice left to squeeze for Gemini to tell you exactly how tall Ke$ha is or when the last time Brittney Spears went to jail was...

But there is a ton of juice left to squeeze when it comes to post-training/RL for a ton of useful things in practice, right? It’s been amazing seeing how good modern model tool use is for example, and I bet there is a lot of room for improvement still (no doubt that a ton of improvement can be made more easily on the agent harness front or via post-training regimes like LoRa (which does support to your point about diminishing pre-training juice))

Woah - I just drove by the JCV institute in La Jolla yesterday and felt thinking that the organization was really monumental to synthetic biology. Rest in peace

The company I work at has been building a dementia prevention program covered by most insurance plans in the US. Our clinicians work directly on helping understand risk of neurodegenerative disease and help tailor personalized plans to improve outcomes. A recent lancet study concluded that around 45% of dementia cases are preventable [0] Happy to answer any questions people have.

https://www.betterbrain.com

Disclaimer : I work as the CTO at BetterBrain

[0] https://www.thelancet.com/commissions-do/dementia-prevention...

This is really interesting, congrats on the launch. The use case I’m trying to solve for is building a coding agent platform that reliably sets up our development stack well. Few questions! In my case, I’m trying to build a one-shot coding agent platform that nicely spins up a docker-in-docker Supabase environment, runs a NextJS app, and durably listens to CI and iterates.

1) Can I use this with my ChatGPT pro or Claude max subscription? 2)

This is really interesting! Pretty remarkable that the key insight isn't just about crossing the BBB—it's about repairing the transport machinery itself.

We're building BetterBrain around this insight—catching vascular and metabolic risk factors that compromise BBB integrity years before severe pathology. Not replacing breakthrough therapies like this, but complementing them by intervening earlier in the cascade. (www.betterbrain.com/insurance if anyone would like to try - its $0 with most insurance plans)

Congrats on the fundraise! I've been a fan of Counsel and admire Muthu's bullishness around asynchronous care delivery.

Overall, I felt the human-clinician side of the product worked quite well - the providers responded quite quickly, were well informed, and resulted in a quick turnaround to getting an Rx or some manner of outcome.

On the AI side, I would caution that your team really needs to work quite hard to maintain a defensible moat here.

Other chatbots can’t connect to your medical records to provide personalized advice. They’re also not trained on the latest evidence-based research and can’t bring a physician into the conversation. With Counsel, you get medical-grade AI support backed by physician oversight, ensuring safe, high-quality care

"can’t connect to your medical records to provide personalized advice" - while I think Counsel's HIE integrations seem to work well (the AI responded with relevant data it had on me from the exchange), that's is reasonably easy to build (which does sound like the famous Dropbox comment).

"They’re also not trained on the latest evidence-based research" - on this note, I'd be curious if Counsel is capable of doing meaningful post-training to meet this endpoint (I'd assume it's not worth the resources to explore any manner of post-training). It strikes me as a good example of Sam Altman's steamrolling comment - I'd imagine the next waive of frontier models will represent a much greater level of health inference than post-training a current frontier model will accomplish.

tl;dr - I found myself immediately skipping over the AI functionality but did find the human physicians on Counsel's app to work great.

Granted, I'm curious to see the company's direction long-term — perhaps along the lines of a16z's healthcare superstaffing thesis (which sounds compelling) or aiming to have most encounters be between a user and AI (which I'm more bearish about, though it's definitely going to happen one day, of course).

Vibe engineering 10 months ago

I think the key is remind yourself is that an engineer is supposed to solve business problems. So use these new tools to be more effective in doing so. An analogy is that people used to spend tons of time building out web server code but something like Django added tremendously useful abstractions and patterns to doing so, which allowed people to more productively add business value

This is very much part of the motivation behind BetterBrain, the wait for an in-network neurologist is often 6+ months, but the wait for one of the few in-person dementia prevention clinics can be years (and cost thousands out of pocket). If your insurance plan covers BetterBrain, definitely recommend giving our insurance covered option a try to meet with a clinician as soon as next week. We do have a free option, with the ability to purchase bloodwork and additional testing.

Yes, there are indeed paid options! We regularly support clients who travel to NY or Vermont for bloodwork. Our co-founder is Canadian and we work with many clients from Canada. Could you shoot me an email and our team can help figure out the logistics? adi@betterbrain.com (Happy to send you a discount code)

BetterBrain | Software Engineer | Remote (USA)

About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition. Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements 4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role (for example - a project you owned) Join us at BetterBrain and help us build a healthier future.

This is neat but I wasn’t able to get it to work (server overloaded is what the browser app said) I’d also recommend registering a custom domain in Supabase so the Google SSO shows the golpo domain - which is a small, but professional-signaling affordance

BetterBrain | Software Engineer | Remote (USA)

About BetterBrain

BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition. Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities

Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements

4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply

Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role (for example - a project you owned)

Join us at BetterBrain and help us build a healthier future.

BetterBrain | QA Engineer | Remote (for exceptionally qualified candidates)

About BetterBrain

BetterBrain (https://www.betterbrain.com) leads in dementia prevention with a comprehensive platform for cognitive health.

Role Overview

Join our rapidly growing team as a QA Engineer. You will be crucial in ensuring the quality, reliability, and performance of our platform, playing a key role in a high-growth startup building innovative health solutions, including AI features.

Key Responsibilities

Design and execute test plans and test cases (manual and automated). Identify, document, and track software bugs. Collaborate with development and product teams on quality. Contribute to test automation efforts.

Requirements

4-5+ years QA or software testing experience. Proven experience in high-growth startups. Experience testing web applications, APIs, and potentially AI/ML features. Familiarity with QA tools (bug tracking, test case management, automation frameworks). Excellent attention to detail and problem-solving skills.

How to Apply

Email adi@betterbrain.com with the subject "HN Hiring - QA Engineer". Include your resume and a brief statement on why you're a good fit.

No staffing/talent agencies.

Hey Seth and Ayo - congrats on this launch. While I think there’s certainly room for improvement, which I’ll address below - this demo makes me feel that you both can keep grinding and succeed with this. The main feedback I have is similar to others who asked how this is better than Cursor running with a react native codebase and iOS simulator running on the side. I read your response about being better at iOS/android specific things could be the case (for example, making it really nail payments and subscriptions could be useful) - but it is definitely going to be a tough battle. If someone can only use your platform and reliably have a react native codebase (version controlled on GitHub), with working Supabase auth, and fully synced with Expo (so basically almost ready to go)- that would be pretty cool! I also think there’s room for you guys to add value around some of the other annoying parts of launching a native app. If your app was able to automatically make App Store creatives and essentially publish the app for me with some user-promoting - that would be sick

Are you looking for a job? I’m hiring a software engineer and was definitely impressed by reading this story! Regardless, you should definitely consider working at a startup - the world is full of annoying gatekeepers to innovation. When I was an undergraduate, I built a system to better forecast and map campus bus shuttle routes and also received a letter like this

BetterBrain | Software Engineer | Hybrid (Boulder, Colorado, USA), Remote (for exceptionally qualified candidates) About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition. Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements 4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role. (Please note that the experience requirement is firm) Join us at BetterBrain and help us build a healthier future. Please do not contact us if you're representing a staffing or talent agency.

BetterBrain | Software Engineer | Hybrid (Boulder, Colorado, USA), Remote (for exceptionally qualified candidates)

About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition.

Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements 4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply

Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role. (Please note that the experience requirement is firm) Join us at BetterBrain and help us build a healthier future.

Please do not contact us if you're representing a staffing or talent agency.

BetterBrain | Software Engineer | Hybrid (Boulder, Colorado, USA)

About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition.

Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements 4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role. (Please note that the experience requirement is firm)

Join us at BetterBrain and help us build a healthier future.

SEEKING FREELANCER

BetterBrain | Software Engineer | Must have significant overlap with US-timezones

About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition. Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements 4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in Supabase, NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply Email us at adi@betterbrain.com with the subject line "HN Hiring - Freelancer". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role.

BetterBrain | Software Engineer | Remote (USA)

About BetterBrain BetterBrain (https://www.betterbrain.com) is at the forefront of dementia prevention. We offer the most comprehensive platform to help our members prevent neurodegenerative diseases and optimize their cognition.

Role Overview We're rapidly growing and are seeking a talented Software Engineer to join our team and help shape the future of preventative neurology. As a full-stack engineer with experience in high-growth startups and building AI products, you’ll play a key role in our development.

Key Responsibilities

Develop and maintain web applications using our tech stack: NextJS, React, Typescript, and Supabase. Collaborate with cross-functional teams to design, develop, and implement new features.

Requirements

4-5+ years of full-stack development experience. Proven experience in high-growth startups. Strong background in building AI products. Proficiency in NextJS, React, Typescript, and Python. Excellent problem-solving skills and attention to detail.

How to Apply

Email us at adi@betterbrain.com with the subject line "HN Hiring". Please include: - A copy of your resume. - A brief description of why you think you’re a good fit for this role.

Join us at BetterBrain and help us build a healthier future.