Nevaeh

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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family: https://www.nature.com/articles/s41467-023-41476-3

"These mutations unexpectedly allowed the usually host-restricted avian influenza polymerase to use the shorter human ANP32A and B and thus partially adapted the viral polymerase for replication in mammals. Although unintended, this consequence clearly indicates the importance of a robust genome editing strategy and subsequent appraisal that includes challenge with multiple avian influenza genotypes at non-physiological exposure levels to rule out the opportunity for adaptive viral evolution."

Full disclosure: https://twitter.com/SolidEvidence/status/1651765620877172736

Thank you for the suggestion, you may have spared me from one of the biggest regrets of my life.

However, I find it hard to say the words, it doesn't really need to be said, it is known. It's a cultural difference for me.

In return, all I can offer is the notion that you are not alone. This is something that probably all of us have to face one day.

Also, I recall the story of Richard Feynman in his old age walking with his friend joking about his surgery & illness, and his friend remarked that he is sad because Feynman was probably going to die soon. Then Feynman said that he has told so many stories over his lifetime, and it feels like he's won't really be completely gone as long as those stories are remembered.

The 42 song by Coldplay encapsulates this.

"Those who are dead are not dead, they're just living in my head"

https://www.youtube.com/watch?v=nkZJc7oA9cE

  In reality, it is the guts of fish that rot and stink before the head. 

  The guts of fish will start to rot quickly and spread terrible bacteria and disease throughout the entire fish.

Hope this helps. I'm not sure why you were downvoted for expressing curiosity about fish biology.

With regard to Nikola Tesla, I see some interesting parallels with Elon Musk. Below is an excerpt from his biography.

  Elon exhibited all the traits of a curious, energetic tot. He picked things up easily, and Maye, like many mothers do, pegged her son as brilliant and precocious. “He seemed to understand things quicker than the other kids,” she said. The perplexing thing was that Elon seemed to drift off into a trance at times. People spoke to him, but nothing got through when he had a certain, distant look in his eyes. This happened so often that Elon’s parents and doctors thought he might be deaf. “Sometimes, he just didn’t hear you,” said Maye. Doctors ran a series of tests on Elon, and elected to remove his adenoid glands, which can improve hearing in children. “Well, it didn’t change,” said Maye. Elon’s condition had far more to do with the wiring of his mind than how his auditory system functioned. “He goes into his brain, and then you just see he is in another world,” Maye said. “He still does that. Now I just leave him be because I know he is designing a new rocket or something.”

  Other children did not respond well to these dreamlike states. You could do jumping jacks right beside Musk or yell at him, and he would not even notice. He kept right on thinking, and those around him judged that he was either rude or really weird. “I do think Elon was always a little different but in a nerdy way,” Maye said. “It didn’t endear him to his peers.”

  For Musk, these pensive moments were wonderful. At five and six, he had found a way to block out the world and dedicate all of his concentration to a single task. Part of this ability stemmed from the very visual way in which Musk’s mind worked. He could see images in his mind’s eye with a clarity and detail that we might associate today with an engineering drawing produced by computer software. “It seems as though the part of the brain that’s usually reserved for visual processing—the part that is used to process images coming in from my eyes—gets taken over by internal thought processes,” Musk said. “I can’t do this as much now because there are so many things demanding my attention but, as a kid, it happened a lot. That large part of your brain that’s used to handle incoming images gets used for internal thinking.” Computers split their hardest jobs between two types of chips. There are graphics chips that deal with processing the images produced by a television show stream or video game and computational chips that handle general purpose tasks and mathematical operations. Over time, Musk has ended up thinking that his brain has the equivalent of a graphics chip. It allows him to see things out in the world, replicate them in his mind, and imagine how they might change or behave when interacting with other objects. “For images and numbers, I can process their interrelationships and algorithmic relationships,” Musk said. “Acceleration, momentum, kinetic energy—how those sorts of things will be affected by objects comes through very vividly.”

How do you feel about acronyms? Do they improve or hurt communication?

From time to time, Musk will send out an e-mail to the entire company to enforce a new policy or let them know about something that's bothering him. One of the more famous e-mails arrived in May 2010 with the subject line: Acronyms Seriously Suck:

  There is a creeping tendency to use made up acronyms at SpaceX. Excessive use of made up acronyms is a significant impediment to communication and keeping communication good as we grow is incredibly important. Individually, a few acronyms here and there may not seem so bad, but if a thousand people are making these up, over time the result will be a huge glossary that we have to issue to new employees. No one can actually remember all these acronyms and people don't want to seem dumb in a meeting, so they just sit there in ignorance. This is particularly tough on new employees.

  That needs to stop immediately or I will take drastic action - I have given enough warning over the years. Unless an acronym is approved by me, it should not enter the SpaceX glossary. If there is an existing acronym that cannot reasonably be justified, it should be eliminated, as I have requested in the past.

  For example, there should be not "HTS" [horizontal test stand] or "VTS" [vertical test stand] designations for test stands. Those are particularly dumb, as they contain unnecessary words. A "stand" at our test site is obviously a test stand. VTS-3 is four syllables compared with "Tripod", which is two, so the bloody acronym version actually takes longer to say than the name!

  The key test for an acronym is to ask whether it helps or hurts communication. An acronym that most engineers outside of SpaceX already know, such as GUI, is fine to use. It is also ok to make up a few acronyms/contractions every now and again, assuming I have approved them, e.g. MVac and M9 instead of Merlin 1C-Vacuum or Merlin 1C-Sea Level, but those need to be kept to a minimum.

History has shown that the CCP will oppress the Han chinese if they do not bow down to their ideology.

"approximately 65,000 Falun Gong practitioners had been killed for their organs between 2000 and 2008" https://en.wikipedia.org/wiki/Organ_harvesting_from_Falun_Go...

Hmm, I'm not sure. On second thought, it could be a legal copyright issue to use famous voices in a monetary setting. Also, it could perhaps be abused somehow despite its huge entertainment potential.

Vocodes is super cool and fun to play with, well done. I wonder if it's possible to turn it into a text-to-speech donations service for Twitch streamers? The current TTS voices are rather monotone. Some donators test how their text donations would sound like on this website: https://textreader.pro

P/S: Small typo on the first sentence on the about page.

Elon Musk decided to disconnect from Twitter a few hours before this was posted. I guess sometimes one must disconnect to connect.

There are 27,000+ partnered Twitch streamers that probably makes a decent amount of money. But the majority probably can't make a living with streaming alone. The top 0.01% of partners like Shroud or DrDisrespect can make millions.

https://www.twitch.tv/year/2017/factsheet.jpg

The mod team is quite important indeed.

https://streamernews.tv/2015/10/28/guest-writer-moblord-disc...

The Fate of the West: The Battle to Save the World's Most Successful Political Idea.

This review claims it's the best book of 2017 and sums it well: https://www.amazon.com/gp/review/R24LMIB16JWMLC?ref_=glimp_1...

Perhaps digital interaction can help alleviate the negative symptoms of loneliness and social isolation. One can join any community which shares their interests and interact in real-time.

https://www.twitch.tv/directory/game/IRL https://www.twitch.tv/directory/game/Creative

However, I am unsure if virtualization of social interaction is beneficial in the long run.

Elon himself has contemplated this apparently. In this interview below, he admits he is a bit crazy.

http://www.youtube.com/watch?v=uegOUmgKB4E#t=1m47s

Elon: "I think I probably am a bit crazy. But I think maybe that’s sort of a healthy sign. Because there’s a point at which you can conclude that you're not crazy at all, then you probably are. It's sort of a recursive thing."

At the risk of invading Elon's personal life, one could go further and investigate his father Errol Musk, who was an electrical & mechanical engineer back in South Africa, to see if there is a biological explanation for any potential personality disorders.

Elon said this about his father: "Quite an astute engineer, although he's gone a little crazy later in life. I don't think he has all his cookies in the jar." Source: http://www.gq.com/news-politics/newsmakers/200901/elon-musk-...

Does this mean that Elon is crazy? I have no idea, but I think that he's a very logical person with life experiences that makes him a huge risk taker. For example, he tweeted briefly about the benefits of near death here: https://twitter.com/elonmusk/status/152394000857448448 On his google plus about page, he wrote "Not dead yet" on his bragging rights section. So really, his worst case scenario is dying. That's his mental trick of making so many crazy risky decisions, as long as they are based on logic. That mindset cannot simply be attained by anyone, you have to experience near-death to truly get it. Mike Lazerow is another good example of such an entrepreneur. Background Story: http://www.lazerow.com/2012/06/a-new-beginning.html#tpe-acti...

Also he thinks that people should be less risk averse (8m10s) because even if they fail, it's not like they're going to starve. Source: http://www.youtube.com/watch?v=5nMQ0-1jqFs#t=5m55s This is probably based on his college experiment of eating for just $1 a day without getting scurvy, or perhaps his direct observations of starvation in South Africa. I honestly have no idea, just pure speculations.

So yeah, I hope that helps enlighten a little bit of how Elon can be such a risk-taker.

A similar question was asked on Quora as well: http://www.quora.com/Elon-Musk/How-is-Elon-Musk-so-intellige...

A Tesla employee actually answered the Quora question on 10/30/12, Tuesday. Might be useful information for other aspiring entrepreneurs on HN.

Kids can get cancer too. If you had billions of dollars, and you lost someone dear due to cancer, wouldn't you try to fix it?

As someone who lost a few loved ones to cancer, I wished the same thing. It'd be awesome if Elon tried to innovate healthcare.

But unfortunately, it is very unlikely according to what Elon said in an interview: Source: http://www.gq.com/news-politics/newsmakers/200901/elon-musk-...

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Elon: "It's important enough to be on the scale of life itself, and therefore goes beyond the parochial concerns of humanity," Musk says of our interplanetary destiny. "We're all focused on our little things that are of concern to humanity itself. People think of curing AIDS or cancer as being very important, and they are—within the context of humanity. But curing all forms of cancer would improve the average life span by only two to three years. That's it."

"In other words, while eradicating disease is a worthy pursuit, and would extend the lives of individual human beings, my life's work is extending the life span of life itself."

----------------------------------------------------

Interesting to hear that coming from someone who has 5 kids. http://www.forbes.com/pictures/mkm45fjlie/elon-musk-10/#gall...

By the way, Elon did talk about some projects he would like to do if he had the time. http://www.youtube.com/watch?v=5FESP1h7IZM

Could you please elaborate? Were you referring to the stories told in his book, or were you actually one of Feynman's students?

Here's the written story of Feynman's experimentation with ants if anyone is interested: http://books.google.com/books?id=7papZR4oVssC&pg=PA94...

A similar question was asked on Quora, and there were some pretty good answers. http://www.quora.com/What-is-it-like-to-work-with-Elon-Musk

I apologize for the hero worship, but I was merely trying to share some information that might be interesting to others. Elon is by no means perfect, his public speaking needs a lot of work, for example. Curiously though, he doesn't stutter at all when he was interviewed by Hannah. =)

Elon probably shares your sentiments, since he was an avid reader of Feynman. Source: http://www.iop.org/careers/workinglife/profiles/page_37749.h...

Feynman himself once said that he didn't like honors: http://www.youtube.com/watch?v=f61KMw5zVhg

So when Elon won the Lady Vivamus sword after accepting the heinlein award for advances in space commercialization, he fools around with it instead of just being another trophy, sometimes to impress the ladies: http://www.youtube.com/watch?v=zRpqZjfFzGg

Just 3 weeks ago, Elon received the Mars Pioneer Award from the Mars Society. Here is his acceptance speech: http://www.youtube.com/watch?v=PK0kTcJFnVk#t=10m56s

I look forward to listening to his next speech, hopefully geared towards motivating others to innovate new world changing technology. Something like his Caltech speech: http://commencement.caltech.edu/archive/2012_address

>"I think it's really important that we stop sending college and graduate students back to their home countries. If you're trying to create a company, it's like baking a cake. You have to have all the ingredients in the right proportion. There's certain special skills, especially in advanced engineering, that are the limiting factor in creating new companies; we send these people home after training them in our graduate schools.

One of the toughest things I've found is to recruit top-notch manufacturing talent. That's where I've had to go overseas. For a few decades, it just wasn't where the smartest kids in the class in America went. We had far too many smart people in the U.S. go into finance and law!"

Interesting. I thought only U.S. citizens were allowed to work for SpaceX, but Elon actually had to go overseas to recruit top-notch manufacturing talent.

With the introduction of multiple bills recently to retain foreign talent such as the STEM Jobs Act, Startup Act 2.0, STARS Act, The Fairness for High-Skilled Immigrants Act, it's good to see some progress made to solve this problem.

According to his twitter feed, Elon himself will explain further in about 4 weeks. No patents, just open source. https://twitter.com/elonmusk

Elon have also made a few Dr.Evil references. =) http://i.imgur.com/MgdDr.jpg

Yes, the collective efforts of engineers should be praised.

Elon himself would agree, since he once said in an interview: "“No, I’ve never aspired to be an astronaut–I have aspired to invent things,” “In fact, I think an error was made in the Apollo program in that there was too much lionizing of the astronauts. Not that they don’t deserve to be lionized, but the real difficulty was the creation of the rocket–it was the engineering and the invention of rocketry.”

Kids should aspire not to be astronauts but to be engineers."

Elon doesn't explicitly state on most interviews how awesome his engineers are, but he did express it when the space station docking mission was successful during the post-interview. http://www.youtube.com/watch?v=YjuvIlskUf4#t=7m20s

Also, he recently delivered a speech at Caltech. He told the grads to go out there and change the world with engineering. His speech was really focused on the Arthur C Clarke quote: "Any sufficiently advanced technology is indistinguishable from magic. And who wouldn't want to be a magician?"

Yes.. it was interesting to hear that coming from someone who has 5 kids: http://www.forbes.com/pictures/mkm45fjlie/elon-musk-10/#gall...