Nesco

Pretty cool, I actually explored the same idea several months ago, as you can put a huge amount of information while keeping emphasis on local features

https://paperverse.net/

I see you also hade a similar idea on what happens when you click on an arrow

Last time I went there I saw a founder that couldn’t do an interview without changing zyn pouches every literal five (5) minutes

American execs negotiating memory two months ago in Korea?

You lost me at “except billionaires”. I don’t see how Jeff Bezos benefits from this one much more than let’s say Terence Tao.

Can a tech news stay a tech news, without getting bombardes with leftist subtexts all the time?

After a time the codebase feel foreign…

retired?

Same, I really want to like Zed but LazyVim covers my every need

Conductor is really nice! A feature I would really like would be to be able to automatically configure “direnv allow” in the different shells as I use nix & direnv all the time

I had this opinion until I actually had a new model and felt the weight difference.

The duality of Man

Synthetic biology: changing genes or expression of genes in cells, etc

What do you mean exactly by “Epstein People”? I thoroughly hope it’s not the 4chan definition of it

Liberalism (in the traditional economic sens) likes competition. Capitalism is a mode of production, and capitalists notoriously don’t like competition when they are the incumbents

First yes it is. The claims that this time period was too short to meaningfully change phenotypes in human populations was not entirely far fetched.

Then to address the elephant in the room - which is the race discourse subtext let’s be honest - it’s highly unlikely that any recent selective pressure on a separated population, which resulted in meaningful phenotype adaptations, happened similarly everywhere at the same time

“What scientists are wary of is how any discussion in the field gets jumped on and twisted into ammunition to reinforce racist beliefs”

Yet nothing ruined the reputation of the scientific establishment more in recent time than their tendency to change their behaviours and adapt their beliefs for political motives

There is a graph arguing “intelligence” has been positively selected in west Eurasian population in this paper according to a polygenic score (page 8 fig. 4)

Now I would be quite curious to know how they constructed this polygenic score

Synbio but it’s expensive as hell

Latin America isn’t a country and Venezuela wasn’t developing in any sens of the word

What country would be the stereotypical example you are thinking of? I fail to find any

Well, this has been entirely vibecoded, so not sure the code itself has any value. It's a 2K line index.html that you can check here if you wish too: https://github.com/nesco/paperverse

Which it can’t. There is nothing to disagree about. With current demographics projection no amount of taxes can cover welfare states

Wait, isn't Devstral2 (normal not small) 123b? What type of laptop do you have? MacBooks don't go over 128GiB

Thank you for your hard work. I don’t have a lot of time right now but would love to try to contribute to FreeBSD early next year

Created a tiny tech blog aggregator, after noticing the same blogs appeared over and over on HN’s front page: https://techblo.gs

It was mainly an excuse to learn Go to be frank.

Also to anyone reading this I am taking any blog suggestion you could have

Location: Paris, France

Remote: Yes

Willing to relocate: yes

Technologies: Python, Typescript, Go, React, FastAPI, etc

Résumé/CV: https://drive.google.com/file/d/16H7288XVqhjbdmjkJA2wm0SPbA_...

Email: emmanuel@federbusch.fr

Hi, I'm Emmanuel. I have 5+ years of experience in software and product. I like smaller companies and fast paced work environments. Feel free to send a mail or a PM if you have any questions

Arc Browser, Arc Prize, Arc Institute and now the Arc Warehouse

I am afraid “Arc” became too fashionable this decade and using it might decrease brand visibility

Let’s be real: both of us have no idea of how it would play out. Pharma companies will try to add them to their stack at some point, and then the real world data we currently lack will decide for everyone

Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier

Yes, but also BAM15 and mRNA based UCPs overexpression

Longer term if it works more research in the domain, including variations of the other well known ones (DNP, XCT-790, mitoCCCP, …)

I firmly believe that combined with:

- additional progress on the current targets (GLP-1, GIP, …)

- compounds to counteracts muscle loss like myostatin inhibitors

- food options being shaped by more health conscious consumers

Having a slow metabolism will stop being an disadvantage by midcentury

I am pretty sure uncouplers will make a come back. Just something a little more targeted and safer than good ol’ DNP

Yeah, trying to create one right now to try to do some E Coli + Desnoyer’s style flower experiments.

I really underestimated the cost