HN user
Simple trick for those outside of academia. Google the impact factor of the journal you are reading. If it's below 5 it's fake. If it's 5 or above, it's also fake.
Is the mitochondria the powerhouse of the cell?
Chat paused. Fable 5's safety features have flagged this chat.
See also https://youtu.be/uJkoI5TnKzA
Help, it's 1 a.m. and I haven't eaten dinner!
Alternatively, the "feel free to leak all my data but please use my GPUs and don't rm -rf /" config:
{
"sandbox": {
"enabled": true,
"filesystem": {
"allowRead": ["/"],
"allowWrite": [
".",
"/tmp",
"/dev/nvidia0",
"/dev/nvidia1",
"/dev/nvidia2",
"/dev/nvidia3",
"/dev/nvidia4",
"/dev/nvidia5",
"/dev/nvidia6",
"/dev/nvidia7",
"/dev/nvidia8",
"/dev/nvidiactl",
"/dev/nvidia-uvm"
]
}
}
}Announcement: https://x.com/KempnerInst/status/2036832290894962819
Blog/write-up: https://kempnerinstitute.harvard.edu/news/harvard-researcher...
Latent Labs (a $200M company) launched an "autonomous AI agent for drug design" that appears to wrap open-source models behind a paywall. Tristan Farmer built an alternative with Claude Code in a day and has interesting things to say about it: https://www.linkedin.com/posts/tristan-farmer-973b7a17a_anti...
Unrestricted link: https://web.archive.org/web/20260325194514/https://www.linke...
Amazingly, the first author is a high school student! https://nathanchen.me/public/About%20me.html
I am choosing to believe this is satire. A+
Paywall-free link: https://archive.ph/lM6ZS
Primary source in Nature Medicine: https://www.nature.com/articles/s41591-026-04239-3
Underlying Foster & Rahmstorf paper is also on the front page (https://news.ycombinator.com/item?id=47275088). This Nature piece adds context and estimates from other experts in the field.
To me, model card makes sense for something like this https://x.com/OpenAI/status/2029620619743219811. For "sheet"/"brief"/"primer" it is indeed a bit annoying. I like to see the compiled results front and center before digging into a dossier.
Surely this is already happening with our other devices? Not that it isn't a problem but that the game is already lost...?
In the article they make that 2025 is a tipping point where open source frameworks and libraries "just work", making speedy, fun development possible without needing to fight the clunkiness of heavyweight engines.
And any new stuff regarding Celeste or from their devs will forever be relevant to me! Highly recommend to any who haven't played it.
"fewer" doing a lot of work here
I like to think that all these pelican riding a bicycle comments are unwittingly iteratively creating the optimal cyclist pelican as these comment threads are inevitably incorporated in every training set.
Two papers that might be of interest to people regarding this topic would be Kirsch 2014 and Cipriani 2018.
And yes, agreed with argwhat.
The truth about antidepressants is that the majority of people with depression that respond to an antidepressant would also have responded to a placebo. This doesn't mean that their depression isn't real or that antidepressants "don't work". It just means that placebo has a relatively high response rate in trials for depression. The hate is (among other points) because they are only arguably, marginally, better than placebo, and antidepressants also have real side effects (activation syndrome, increased suicidality, sexual side effects, withdrawals, etc.) over placebo.
Evolutionary memetics at work!
Glutamate is fascinating! The latest and greatest hypothesis for mood, learning, etc. hot off the press. Suddenly everything targets NMDA/AMPA receptors and increases plasticity
Forcing Google to sell Chrome!
What is so hard to believe? Technology evolves rapidly. I can't imagine that anyone investing big money in compute technology wouldn't have expected that.
Isn't Austin a very left-leaning city? Though, to be fair, the people I know in Austin are deeply conservative Texas natives who hate the new atmosphere...
Edit: I'm missing the point, they said Texas, not Austin.
I have the same issue quite frequently... If I knew any decent alternative with uBlock (or equivalent) I'd switch on the spot! On a Pixel 6.
Firefox mobile is its own beast. I experience a whole host of issues on it, but have never had issues with Firefox on desktop. Only reason I use FF for Android is for uBlock, but it's so unreliable I'm dying for a better option...
Indeed, the article title is a little misleading! Sleep depravation producing short-term improvements in human depression has been well known for some time. What the authors actually propose is an underlying mechanism to that improvement, in mice...
Thank you for this! I have very similar thoughts. Felt like I was going crazy each time I saw these types of conversations sparked by mention of the "repugnant" conclusion...
If anything wouldn't this argument suggest you should isolate and quantify the active ingredient? Certainly there is more variation between two espressos than, say, two 80 mg caffeine capsules.
Conspiracy-theorist goggles on... this is also fraud?! (I have no evidence, just pointing out the possibility)