Medicalidiot

This is why I was having issues watching Youtube 1.5 hours ago. I thought it was my internet, kept doing all kinds of stuff because I was having slow internet in general.

I wonder if this is because people are dating more before getting married, which probably leads to more mature people who know what they're looking for in a spouse.

I have only had getting the steam client to launch, and only after a fresh install. This was mainly on OpenSUSE a few years ago; I could get it working maybe 2/3 times after a fresh install, depending on whether I installed all the hacks in the correct order. Once it started up, I never had problems booting it again.

When you look at the bacteria that generate spores, the only population that is usually affected is neonates; which is why it's advised not to give honey to anyone under the age of 1-2. For spore forming bacteria, they're not prevalent in the environment and their transmission is usually limited.

If we ever have a pathogen like Archaea I will shit my pants. Prions already are able to survive 242F for 15 minutes and caustic chemicals so we already have enough on our plates.

I'm going to pose something that was interesting when the Chief Medical Officer of NASA spoke at my school: bacteria in space will have massive amounts of genetic changes -> bacteria on a Mars mission may become pathogenic to the point where we would not want people who traveled to Mars to come back. He also talked about intracranial hypertension being an issue with people going into space and how to remedy that one. It was fascinating to hear a physician in charge of astronauts talk about what medical challenges needs to be overcome.

Sources: https://en.wikipedia.org/wiki/Archaea https://www.nasa.gov/mission_pages/station/research/news/nan... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509877/ https://pubmed.ncbi.nlm.nih.gov/26099128/

We had our computers go down for ~12 hours one day. Paper charts came out, which was a massive undertaking. I could not imagine my system being down for 5 weeks.

PBS News Hour. I've never watched more boring and informative news in my entire life.

My buddy moved into a closet there ~4 years ago now. His rent was something like $2,500 per month. I am living in an apartment now that has twice the space and better ammenities while only pay $1,000 per month. My friend has since moved to Denver because mainly of price.

Downloading science articles on an "open campus". Something that should be celebrated was instead castigated.

Bachelor's degrees only went down slightly, which isn't too surprising. What's worrying to me is that associates and certificates have dropped significantly. Both are primarily for individuals who are in lower socioeconomic status categories, which is more emblematic that there is a problem than anything else.

France, the one country that challenged US intelligence because their own intelligence contradicted the CIA and NSA reports. Absolute studs.

I didn't even think of that, but that's probably a good idea at this point.

I went from Ubuntu to Fedora because of the recent decisions made by the devs and the hard push of Snaps. I use Chromium every once in awhile and am amazed at how long it takes for it to start up; it's almost instantly on every other distro.

I was an early adopter of Voat during the first Reddit purge but it turned into a racist cesspool. I'm wondering how many of these alternatives will follow that trend.

Malaria is probably going to be one of the hardest maladies to overcome. There was some promise with a vaccine, but it looks like that was fairly disappointing. The selective pressure is so high with malaria that sickle cell anaemia is a fairly common congenital disease that if one is homozygous for can be lethal in early age; conventional medicine has significantly increased life expectancy, but it's still fairly poor. Hopefully, it will be to the point where it can be controlled because the African continent has had its economies ravaged by it.

https://en.wikipedia.org/wiki/Malaria#Economic_impact

Let me build some credibility here: I have been working out for roughly a decade, have gained over 70lbs, and was ranked in the advanced category (set by ExRx standards) of dead lift, squat, and bench.

Now, my suspicion is that the target demographic for this "works out" for social benefits, not for actually making fitness progress. I say this because someone who takes fitness seriously would never drop $1500 on an accessory that a pen and journal wouldn't be more than capable for. For that kind of money a home gym is more than accessible. Even a few kettlebells for even 1/4th of that would get someone into phenomenal shape. For a significant amount of my fitness career I did yoga at a local studio and met many of the target demographic. Many wanted a way to stay in shape while also having a social aspect. This abrogates the social aspect while having a sub par fitness experience. I can only think of a demographic that doesn't understand fitness at all, has significant money, and doesn't want the social aspects of a group fitness class; this demographic is probably niche.

A company's "main players" are its board and senior management

Ah I see that we have different definitions of main players. I'm thinking of developers who are able to mess with the code. But the Wikipedia does support what my definition of main players means.

Just because the board doesn't report to CCP doesn't mean that someone significant in the 700 isn't an assent of the CCP and able to do significant damage.

Zoom's product development team is largely based in China

The main players are under CCP command.

https://en.wikipedia.org/wiki/Zoom_Video_Communications#Work...

"Secretly" is a misnomer.

I'd love to have one of these in my gaming rig, but even with my 1700 I rarely have cpu bottlenecks.

Personally, I would like to a see a government sponsored test where the study materials are provided for free. I feel like that would help decrease the amount of people who couldn't afford the prep courses or tutors. Not ideal, but better than the current system where wealthy parents pay for the best tutors and materials.

https://press.uchicago.edu/Misc/Chicago/511928.html

How do y'all think this nationwide housing crisis will precipitate?

A friend of mine lived in the bay area for a bit and ended up leaving because he couldn't handle the virtue signaling. From his experience a significant amount of people would talk about helping low socioeconomic folk, oppression, or any other in vogue topic but never actually do anything. These would then be the loudest voices lobbying against having a methadone clinic in their neighborhood. He's living in Denver now which has a similar problem but on a palatable scale, according to him.

I am a massive Civ VI fan even though I understand the criticism. Running it on Linux is a far better experience for me than V, but both are phenomenal strategy games in their own right.

The other day when HK leaders were dragged out of the legislative building was surreal. It's something that I would have thought would only be seen by a dictator in the developing world, not in one of the most advanced cities in the world. It only adds to the adage that freedom must be continually fought for.

I would sometimes read NYT articles during down time at my old job. The amount of advertising and JS on the site without and adblocker is atrocious. I ended up going to other news sites because NYT was so bad. Still, it's nowhere near as bad as WaPost.

My best friend is working on novel targets for hepatocellular carcinoma. Does he know science? Yes. Does he know how to bring a drug to market? God no. Everyone outside of your field is a lay person.

Med school doesn't qualify you to opine about novel therapeutics

Actually, it does. Especially when we tried hydroxychloroquine and it didn't work. When you go to a hospital with medical students 60% of the time our recommendation to the attending is what the care plan ends up being.

Both are involved in discovering novel drug targets, but not in bringing drugs to market. I know a significant amount of individuals in medical research that don't know the nuances behind bringing drugs to market.

There are a few things that cause me serious frustration. One is when a lay person will talk about medicine.

Making drugs is a ridiculous process. I had the pleasure of listening to a physical chemist describe every single step it took for his team at Abbott labs to take Lopinavir/ritonavir to market. It is incredible how difficult it is to go from novel molecule to phase IV. Every single thing he did he had to, by FDA guidelines, be written and documented appropriately. Everything is highly scrutinized. With medicine we need to be right and we need strong scrutiny, because when there isn't oversight shortcuts are made. That's just the federal guidelines, the chemistry behind drug production, and this is something I find interesting but strongly dislike the amount of math behind physical chemistry, is intimidating. Some of the questions that need to be answered are: Does this molecule affect any enzyme? Is this enzyme hypothesized to be in a disease process? What is the structure of this molecule? How is it made? How can we make more? How can we make more more efficiently? Does this drug work in people? What's the dose that needs to be given to have an effect? What is the dosing ranges for a given drug? What are the serious side effects? What are the moderate/mild side effect? How is this drug cleared/excreted? Are there certain populations which this is contraindicated in?

These are some of the main questions that are answered when taking a drug to market, which is why it usually takes 10 years and billions to go from novel molecule to FDA approved drug.