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JackeJR

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The thing is that with such a sample, we don't really know

1. If the effect is real. i.e. had the patient not been given the injection, would his/her condition improve spontaneously.

2. Assuming the effect is real, what are the circumstances that make the treatment work for this person.

Not to be overly dismissive of the good work but it is too early to be optimistic about this given the above and the fact that the results were not replicated out of Sana suggest that there is a lot that we need to work out before this becomes a viable treatment for the masses.

The harms of hyping this up is that readers will get their hopes up and then be disappointed when things don't pan out as do most scientific endeavours. Overtime, readers will learn to distrust anything that is being reported because 90% of which do not translate to real world impact. It is hard to get the nuance that "science takes many many failures and iterations" to the public and the more likely outcome of such reporting is general distrust of science when things don't go the way that is hoped for.

N=1 study should not have made it into headlines.

Although the research marks a milestone in the search for treatments of type 1 diabetes, it’s important to note that the study involved one one participant, who received a low dose of cells for a short period—not enough for the patient to no longer need to control their blood sugar with injected insulin. An editorial by the journal Nature also says that some independent research groups have failed in their efforts to confirm that Sana’s method provides edited cells with the ability to evade the immune system.

Just have sane firewall rules and you are good. E.g. if I install openssh-server and it auto starts, it doesn't make it out of my machine because my nftables does not allow inbound on port 22. It's just knowing the default behaviour and adjusting your practices for it.

Modern LaTeX 1 year ago

There are many reasons this comparison is not made. I will just touch on one. The target medium is different. For html, you have monitors of different sizes as well as windows that can be resized. For latex, you choose your target at the start: A4 paper? Screen presentation? A0 poster?

With a fixed medium in mind, you can be extremely particular on where on this canvas you want a piece of text/graphic or whatever.

Without a fixed medium, you have to have logic to address the different mediums and compromises have to be made.

For the case of Syria, it is damned if you do and damned if you don't. Red lines were crossed (chemical weapons) and it was only when ISIS emerged that there were boots on the ground.

I have seen chargers that simplify the logic to drop everytime a new device is connected or disconnected to recalculate the max power per port. So these days if I am shopping for a charger say for a IP cam, I assume that each usb C takes 100w and usb A to take 22.5w and calculate what the max draw could be. If the max advertise power budget is at or above this value, then it is a fairly good indication that there will not be any dropping of connection.

The chargers that drop connection is typically because their max power budget per port depends on how many ports are used. E.g if my max power budget is 200w and I have 2 usb c pd and 2 usb A. Each usb c pd can have a max of 100w per pd3.0 specs. So if I have 2 devices plugged in to both usb c, if I need to plug a USB A device in, I need to lower at least one of the usb C to 65W.